PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11804860-2 2002 Agmatinase, which hydrolyzes agmatine to putrescine and urea, not only represents a potentially important mechanism for regulating the biological effects of agmatine in mammalian cells but also represents an alternative to ornithine decarboxylase for polyamine biosynthesis. Polyamines 251-260 agmatinase Homo sapiens 0-10 20563878-7 2011 When comparing the overall agmatinase expression with immunocytochemical data available for agmatine and polyamine biosynthetic enzymes, the observed pattern may argue in favor of an agmatine inactivating function rather than fueling the alternative pathway of polyamine synthesis. Polyamines 261-270 agmatinase Homo sapiens 27-37 24648395-0 2014 Arginine decarboxylase and agmatinase: an alternative pathway for de novo biosynthesis of polyamines for development of mammalian conceptuses. Polyamines 90-100 agmatinase Homo sapiens 27-37 24648395-2 2014 However, metabolism of arginine to agmatine via arginine decarboxylase (ADC) and conversion of agmatine to polyamines via agmatinase (AGMAT) is an alternative pathway long recognized in lower organisms, but only recently suggested for neurons and liver cells of mammals. Polyamines 107-117 agmatinase Homo sapiens 122-132 24648395-2 2014 However, metabolism of arginine to agmatine via arginine decarboxylase (ADC) and conversion of agmatine to polyamines via agmatinase (AGMAT) is an alternative pathway long recognized in lower organisms, but only recently suggested for neurons and liver cells of mammals. Polyamines 107-117 agmatinase Homo sapiens 134-139 24648395-3 2014 We now provide evidence for a functional ADC/AGMAT pathway for the synthesis of polyamines in mammalian reproductive tissue for embryonic survival and development. Polyamines 80-90 agmatinase Homo sapiens 45-50 24648395-5 2014 Furthermore, we found that increases in ADC/AGMAT mRNA levels and in the translation of AGMAT mRNA among conceptuses in MAO-ODC1 knockdown compensated for the loss of ODC1, supporting polyamine synthesis from arginine and accounting for the normal and abnormal phenotypes of conceptuses. Polyamines 184-193 agmatinase Homo sapiens 88-93 24648395-6 2014 We conclude that the majority of polyamine synthesis is by the conventional ODC1-dependent pathway (arginine-ornithine-putrescine) and that deficiencies in ODC1 result in increased activity of the rescue ADC/AGMAT-dependent pathway (arginine-agmatine-putrescine) for production of polyamines. Polyamines 33-42 agmatinase Homo sapiens 208-213 24648395-6 2014 We conclude that the majority of polyamine synthesis is by the conventional ODC1-dependent pathway (arginine-ornithine-putrescine) and that deficiencies in ODC1 result in increased activity of the rescue ADC/AGMAT-dependent pathway (arginine-agmatine-putrescine) for production of polyamines. Polyamines 281-291 agmatinase Homo sapiens 208-213 11914032-1 2002 Arginine decarboxylase (ADC) and agmatinase are part of an operon in Escherichia coli, which constitutes the primary pathway of polyamine synthesis from arginine. Polyamines 128-137 agmatinase Homo sapiens 33-43