PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22159752-0	2012	COX-2-independent induction of apoptosis by celecoxib and polyamine naphthalimide conjugate mediated by polyamine depression in colorectal cancer cell lines.	Polyamines	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5	
19368394-2	2009	Here, a Co(II)-mediated dimeric mithramycin (Mith) complex, (Mith)(2)-Co(II), was shown to be resistant to polyamine competition toward the divalent metal ion when compared to the Fe(II)-mediated drug complexes.	Polyamines	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13	
19368394-2	2009	Here, a Co(II)-mediated dimeric mithramycin (Mith) complex, (Mith)(2)-Co(II), was shown to be resistant to polyamine competition toward the divalent metal ion when compared to the Fe(II)-mediated drug complexes.	Polyamines	107-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75	
19368394-3	2009	Surface plasmon resonance experiments demonstrated that polyamines interfered with the binding capacity and association rates of (Mith)(2)-Co(II) binding to DNA duplexes, while the dissociation rates were not affected.	Polyamines	56-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144	
19368394-4	2009	Although (Mith)(2)-Co(II) exhibited the highest oxidative activity under physiological conditions (pH 7.3 and 37 degrees C), polyamines (spermine in particular) inhibited the DNA cleavage activity of the (Mith)(2)-Co(II) in a concentration-dependent manner.	Polyamines	125-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	214-219	
19368394-5	2009	Depletion of intracellular polyamines by methylglyoxal bis(guanylhydrazone) (MGBG) enhanced the sensitivity of A549 lung cancer cells to (Mith)(2)-Co(II), most likely due to the decreased intracellular effect of polyamines on the action of (Mith)(2)-Co(II).	Polyamines	27-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152	
19368394-5	2009	Depletion of intracellular polyamines by methylglyoxal bis(guanylhydrazone) (MGBG) enhanced the sensitivity of A549 lung cancer cells to (Mith)(2)-Co(II), most likely due to the decreased intracellular effect of polyamines on the action of (Mith)(2)-Co(II).	Polyamines	27-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-255	
19368394-5	2009	Depletion of intracellular polyamines by methylglyoxal bis(guanylhydrazone) (MGBG) enhanced the sensitivity of A549 lung cancer cells to (Mith)(2)-Co(II), most likely due to the decreased intracellular effect of polyamines on the action of (Mith)(2)-Co(II).	Polyamines	212-222	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152	
16741257-0	2006	Polyamine-mediated reduction in human airway epithelial migration in response to wounding is PGE2 dependent through decreases in COX-2 and cPLA2 protein levels.	Polyamines	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134