PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27139465-2 2016 The catalytic efficiencies (kcat/Km) of IMP-1, VIM-2, and L1 for S-649266 were 0.0048, 0.0050, and 0.024 muM(-1) s(-1), respectively, which were more than 260-fold lower than that for meropenem. Meropenem 184-193 vimentin 2, pseudogene Homo sapiens 47-52 32510322-3 2020 Here, we employ deep mutational scanning (DMS) to generate comprehensive single amino acid variant data on a major clinical MBL, VIM-2, by measuring the effect of thousands of VIM-2 mutants on the degradation of three representative classes of beta-lactams (ampicillin, cefotaxime, and meropenem) and at two different temperatures (25oC and 37oC). Meropenem 286-295 vimentin 2, pseudogene Homo sapiens 129-134 30022668-3 2018 We report herein the development, synthesis, and biological evaluation of chemical compounds based on the selective zinc chelator tris-picolylamine (TPA) that can restore the bactericidal activity of Meropenem (MEM) against Pseudomonas aeruginosa and Klebsiella pneumoniae expressing carbapenemases Verona integron-encoded metallo-beta-lactamase (VIM-2) and New Delhi metallo-beta-lactamase 1 (NDM-1), respectively. Meropenem 200-209 vimentin 2, pseudogene Homo sapiens 347-352 29271657-5 2018 Cocrystallization of one inhibitor, which shows potentiation of Meropenem activity against MBL-expressing Enterobacteriaceae, with VIM-2 reveals an unexpected binding mode, involving interactions with residues from conserved active site bordering loops. Meropenem 64-73 vimentin 2, pseudogene Homo sapiens 131-136 31057732-4 2019 Biological evaluation on clinical bacterial isolates, harbouring either the NDM-1 or VIM-2 metallo-beta-lactamase, showed a clear relationship between the zinc chelator strength and restoration of meropenem activity. Meropenem 197-206 vimentin 2, pseudogene Homo sapiens 85-90 23954421-8 2013 Intergenic comparison revealed NDM-1 might have greater drug profile and catalytic efficiency than IMP-1 and VIM-2 due to largest pocket opening and least distance between the Zn-I ion and beta-lactam oxygen of meropenem. Meropenem 211-220 vimentin 2, pseudogene Homo sapiens 109-114