PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14638498-7 2003 The bla(KPC-2) determinant was cloned in E. coli and conferred resistance to imipenem, meropenem, extended-spectrum cephalosporins, and aztreonam. Meropenem 87-96 KPC-2 Escherichia coli 8-13 14638498-10 2003 KPC-2 had the highest affinity for meropenem. Meropenem 35-44 KPC-2 Escherichia coli 0-5 34324652-8 2021 The isolates with high MICs had significantly higher blaKPC-2 expression, which corresponds to phenotypic meropenem inactivation. Meropenem 106-115 KPC-2 Escherichia coli 53-61 30258039-8 2018 Lower MICs for ceftriaxone, cefepime, aztreonam, meropenem, and imipenem for the mutated KPC-2-producing isolates were observed compared to those of the isolates producing a wild-type KPC-2. Meropenem 49-58 KPC-2 Escherichia coli 89-94 35130728-3 2022 Here, we reported that IS26-mediated amplification of blaKPC-2 rapidly and robustly gave rise to carbapenem hyperresistant phenotypes in an Escherichia coli clinical strain following sublethal meropenem or tobramycin preexposure. Meropenem 193-202 KPC-2 Escherichia coli 54-62