PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24123430-1 2014 OBJECTIVES: Two plasmids carrying bla(KPC-2) isolated from carbapenem-resistant Escherichia coli (CR-EC) and carbapenem-resistant Klebsiella pneumoniae (CR-KP), respectively, were completely sequenced. Carbapenems 59-69 KPC-2 Escherichia coli 38-43 25107431-12 2014 This is the first report of a multidrug resistant carbapenem-non-susceptible E.coli co-harboring resistant determinants blaKPC-2, blaCTX-M-14, blaCTX-M-55, blaTEM, aac(6")-Ib-cr, qnrB, aac(6")-Ib and rmtB from Chongqing, mainland China. Carbapenems 50-60 KPC-2 Escherichia coli 120-128 19015357-6 2009 KPC-2 transformants were less susceptible to the carbapenems than KPC-4 and KPC-5 transformants. Carbapenems 49-60 KPC-2 Escherichia coli 0-5 21835972-10 2011 KPC-2- or IMP-producing E. coli transconjugants exhibited reduced susceptibility to carbapenems but were susceptible to polymyxin B and tigecycline with an MIC range of 0.5-2 microg ml(-1), 0.25-2 microg ml(-1), 0.5-4 microg ml(-1), 0.5 microg ml(-1) and 0.5-1 microg ml(-1). Carbapenems 84-95 KPC-2 Escherichia coli 0-5 21835972-11 2011 In conclusion, carbapenem resistance in Enterobacteriaceae is mainly due to production of KPC-2, and polymyxin B is active for the carbapenem-resistant Enterobacteriaceae. Carbapenems 15-25 KPC-2 Escherichia coli 90-95 20231393-0 2010 Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. Carbapenems 0-10 KPC-2 Escherichia coli 21-26 23600675-3 2014 Thus, KPC-2 carbapenems present a significant clinical challenge, as the mechanistic bases for KPC-2-associated phenotypes remain mysterious. Carbapenems 12-23 KPC-2 Escherichia coli 6-11 22542894-6 2012 Production of KPC-2 mainly contributed to the carbapenem resistance in M. morganii. Carbapenems 46-56 KPC-2 Escherichia coli 14-19 23202428-2 2011 CTX-Ms are the beta-lactamases that target cephalosporin antibiotics (e.g. cefotaxime and ceftazidime) while SME-1, KPC-2, IMI-1 and SFC-1 target carbapenems. Carbapenems 146-157 KPC-2 Escherichia coli 116-121 31127297-5 2019 RESULTS: Susceptibility testing revealed that Escherichia coli producing KPC-28 displayed MICs that were lower for carbapenems and higher for ceftazidime and ceftazidime/avibactam as compared with KPC-2. Carbapenems 115-126 KPC-2 Escherichia coli 73-78 18625772-7 2008 Structure analysis and docking simulations with cefotaxime and imipenem provided further insights into the molecular basis of the extremely broad spectrum of KPC-2, which behaves as a cefotaximase with significant activity against carbapenems. Carbapenems 231-242 KPC-2 Escherichia coli 158-163 18332176-0 2008 Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. Carbapenems 119-129 KPC-2 Escherichia coli 157-162 17342651-1 2007 A carbapenem-resistant isolate of Escherichia coli was identified that possessed a 23-kb plasmid encoding Klebsiella pneumoniae carbapenemase type 2 (KPC-2). Carbapenems 2-12 KPC-2 Escherichia coli 150-155 16940107-0 2006 Plasmid-mediated imipenem-hydrolyzing enzyme KPC-2 among multiple carbapenem-resistant Escherichia coli clones in Israel. Carbapenems 66-76 KPC-2 Escherichia coli 45-50 14638498-0 2003 Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2. Carbapenems 0-10 KPC-2 Escherichia coli 98-103 14638498-0 2003 Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2. Carbapenems 60-70 KPC-2 Escherichia coli 98-103 14638498-8 2003 The amino acid sequence of KPC-2 showed a single amino acid difference, S174G, when compared with KPC-1, another carbapenem-hydrolyzing beta-lactamase from K. pneumoniae 1534. Carbapenems 113-123 KPC-2 Escherichia coli 27-32 14638498-9 2003 Hydrolysis studies showed that purified KPC-2 hydrolyzed not only carbapenems but also penicillins, cephalosporins, and aztreonam. Carbapenems 66-77 KPC-2 Escherichia coli 40-45 14638498-13 2003 Thus, carbapenem resistance in K. oxytoca 3127 is due to production of the Bush group 2f, class A, carbapenem-hydrolyzing beta-lactamase KPC-2. Carbapenems 6-16 KPC-2 Escherichia coli 137-142 14638498-13 2003 Thus, carbapenem resistance in K. oxytoca 3127 is due to production of the Bush group 2f, class A, carbapenem-hydrolyzing beta-lactamase KPC-2. Carbapenems 99-109 KPC-2 Escherichia coli 137-142 35130728-3 2022 Here, we reported that IS26-mediated amplification of blaKPC-2 rapidly and robustly gave rise to carbapenem hyperresistant phenotypes in an Escherichia coli clinical strain following sublethal meropenem or tobramycin preexposure. Carbapenems 97-107 KPC-2 Escherichia coli 54-62 33322118-8 2020 We detected two carbapenem-resistant E. coli isolates, one coproducing CTX-M-15, KPC-2, and NDM-1 while the other presented mutations in ompC. Carbapenems 16-26 KPC-2 Escherichia coli 81-86 32966910-5 2020 RESULTS: Strain QE11-421 was the mcr-1-positive colistin-resistant isolate, which coexisted with blaKPC-2 conferring carbapenem resistance. Carbapenems 117-127 KPC-2 Escherichia coli 97-105 33281782-14 2020 Furthermore, the E. coli ST131 strain carrying the chromosomal bla KPC -2 gene could be further spread due to its carbapenem resistance and high virulence. Carbapenems 114-124 KPC-2 Escherichia coli 67-73 31127297-6 2019 The catalytic efficiencies of KPC-28 and KPC-14 for imipenem were 700-fold and 200-fold lower, respectively, than those of KPC-2, suggesting that Delta242-GT-243 in KPC-28 and KPC-14 is responsible for reduced carbapenem hydrolysis. Carbapenems 210-220 KPC-2 Escherichia coli 30-35 30928562-9 2019 Transformation studies with Escherichia coli TOP10 showed that KPC-23 offered similar carbapenem MICs as KPC-2 and KPC-3. Carbapenems 86-96 KPC-2 Escherichia coli 63-68 30753572-6 2019 The novel KPC-2 allele, designated KPC-35, was shown to confer reduced susceptibility to ceftazidime/avibactam and increased susceptibility to carbapenems, as compared with KPC-2. Carbapenems 143-154 KPC-2 Escherichia coli 10-15 29089425-12 2017 KPC-2 is a beta-lactamase that inactivates carbapenems and beta-lactamase inhibitors (e.g., clavulanate) and is prevalent around the world, including in the United States. Carbapenems 43-54 KPC-2 Escherichia coli 0-5 27465241-5 2016 The coexistence of blaNDM-1 and blaKPC-2 conferred higher levels of resistance to carbapenems compared with blaNDM-1 or blaKPC-2 alone. Carbapenems 82-93 KPC-2 Escherichia coli 32-40 27465241-5 2016 The coexistence of blaNDM-1 and blaKPC-2 conferred higher levels of resistance to carbapenems compared with blaNDM-1 or blaKPC-2 alone. Carbapenems 82-93 KPC-2 Escherichia coli 120-128