PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20471977-0	2010	In vitro treatments with ceftriaxone promote elimination of mutant glial fibrillary acidic protein and transcription down-regulation.	Ceftriaxone	25-36	glial fibrillary acidic protein	Homo sapiens	67-98	
29524538-3	2018	We recently found that ceftriaxone, a beta-lactam antibiotic able to overcome the blood-brain barrier, successfully eliminated the cellular toxic effects of misfolded proteins as Glial Fibrillary Acidic Protein (GFAP) and alpha-synuclein.	Ceftriaxone	23-34	glial fibrillary acidic protein	Homo sapiens	179-210	
29524538-3	2018	We recently found that ceftriaxone, a beta-lactam antibiotic able to overcome the blood-brain barrier, successfully eliminated the cellular toxic effects of misfolded proteins as Glial Fibrillary Acidic Protein (GFAP) and alpha-synuclein.	Ceftriaxone	23-34	glial fibrillary acidic protein	Homo sapiens	212-216	
29524538-9	2018	General significance These results, in addition to our previous studies on alpha-synuclein and GFAP, confirm the property of ceftriaxone to inhibit the pathological protein aggregation of lysozyme also by a chaperone-like mechanism, extending the potential therapeutic application of this molecule to some forms of human hereditary systemic amyloidosis.	Ceftriaxone	125-136	glial fibrillary acidic protein	Homo sapiens	95-99	
27133445-0	2016	Interactions of GFAP with ceftriaxone and phenytoin: SRCD and molecular docking and dynamic simulation.	Ceftriaxone	26-37	glial fibrillary acidic protein	Homo sapiens	16-20	
20471977-6	2010	Ceftriaxone has also been shown to modulate the proteasome system, thus decreasing NF-kappaB activation and GFAP promoter transcriptional regulation, which further accounts for the down-modulation of GFAP protein levels.	Ceftriaxone	0-11	glial fibrillary acidic protein	Homo sapiens	108-112	
20471977-6	2010	Ceftriaxone has also been shown to modulate the proteasome system, thus decreasing NF-kappaB activation and GFAP promoter transcriptional regulation, which further accounts for the down-modulation of GFAP protein levels.	Ceftriaxone	0-11	glial fibrillary acidic protein	Homo sapiens	200-204	
20471977-4	2010	Here we show that ceftriaxone is able to reduce the intracytoplasmic aggregates of mutant GFAP in a cellular model of Alexander disease.	Ceftriaxone	18-29	glial fibrillary acidic protein	Homo sapiens	90-94	
33322348-5	2020	To this aim, embryos expressing the human GFAP gene carrying the most severe p.R239C under the control of the zebrafish gfap gene promoter underwent functional validation to assess several features already observed in in vitro and other in vivo models of AxD, such as the localization of mutant GFAP inclusions, the ultrastructural analysis of cells expressing mutant GFAP, the effects of treatments with ceftriaxone, and the heat shock response.	Ceftriaxone	405-416	glial fibrillary acidic protein	Homo sapiens	42-46