PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33754484-0	2021	Association of Sigma-1 Receptor with Dopamine Transporter Attenuates the Binding of Methamphetamine via Distinct Helix-Helix Interactions.	Methamphetamine	84-99	Dopamine transporter	Drosophila melanogaster	37-57	
33754484-1	2021	Dopamine transporter (DAT) and sigma-1 receptor (sigma1R) are potential therapeutic targets to reduce the psychostimulant effects induced by methamphetamine (METH).	Methamphetamine	141-156	Dopamine transporter	Drosophila melanogaster	0-20	
33754484-1	2021	Dopamine transporter (DAT) and sigma-1 receptor (sigma1R) are potential therapeutic targets to reduce the psychostimulant effects induced by methamphetamine (METH).	Methamphetamine	141-156	Dopamine transporter	Drosophila melanogaster	22-25	
33754484-1	2021	Dopamine transporter (DAT) and sigma-1 receptor (sigma1R) are potential therapeutic targets to reduce the psychostimulant effects induced by methamphetamine (METH).	Methamphetamine	158-162	Dopamine transporter	Drosophila melanogaster	0-20	
33754484-1	2021	Dopamine transporter (DAT) and sigma-1 receptor (sigma1R) are potential therapeutic targets to reduce the psychostimulant effects induced by methamphetamine (METH).	Methamphetamine	158-162	Dopamine transporter	Drosophila melanogaster	22-25	
33754484-2	2021	Interaction of sigma1R with DAT could modulate the binding of METH, but the molecular basis of the association of the two transmembrane proteins, and how their interactions mediate the binding of METH to DAT or sigma1R remains unclear.	Methamphetamine	62-66	Dopamine transporter	Drosophila melanogaster	28-31	
33754484-2	2021	Interaction of sigma1R with DAT could modulate the binding of METH, but the molecular basis of the association of the two transmembrane proteins, and how their interactions mediate the binding of METH to DAT or sigma1R remains unclear.	Methamphetamine	196-200	Dopamine transporter	Drosophila melanogaster	28-31	
33754484-2	2021	Interaction of sigma1R with DAT could modulate the binding of METH, but the molecular basis of the association of the two transmembrane proteins, and how their interactions mediate the binding of METH to DAT or sigma1R remains unclear.	Methamphetamine	196-200	Dopamine transporter	Drosophila melanogaster	204-207	
33754484-8	2021	Although different helix-helix interactions between sigma1R and dDAT lead to distinct effects on the dynamics of individual protein, both associations attenuate the binding affinity of METH to dDAT, particularly in the interactions with the helix alpha5 of dDAT.	Methamphetamine	185-189	Dopamine transporter	Drosophila melanogaster	64-68	
33754484-8	2021	Although different helix-helix interactions between sigma1R and dDAT lead to distinct effects on the dynamics of individual protein, both associations attenuate the binding affinity of METH to dDAT, particularly in the interactions with the helix alpha5 of dDAT.	Methamphetamine	185-189	Dopamine transporter	Drosophila melanogaster	193-197	
33754484-8	2021	Although different helix-helix interactions between sigma1R and dDAT lead to distinct effects on the dynamics of individual protein, both associations attenuate the binding affinity of METH to dDAT, particularly in the interactions with the helix alpha5 of dDAT.	Methamphetamine	185-189	Dopamine transporter	Drosophila melanogaster	193-197	
25970245-2	2015	Here we determine X-ray crystal structures of the Drosophila melanogaster dopamine transporter (dDAT) bound to its substrate dopamine, a substrate analogue 3,4-dichlorophenethylamine, the psychostimulants d-amphetamine and methamphetamine, or to cocaine and cocaine analogues.	Methamphetamine	223-238	Dopamine transporter	Drosophila melanogaster	74-94	
25970245-2	2015	Here we determine X-ray crystal structures of the Drosophila melanogaster dopamine transporter (dDAT) bound to its substrate dopamine, a substrate analogue 3,4-dichlorophenethylamine, the psychostimulants d-amphetamine and methamphetamine, or to cocaine and cocaine analogues.	Methamphetamine	223-238	Dopamine transporter	Drosophila melanogaster	96-100