PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24959862-0 2014 Positive and negative feedback learning and associated dopamine and serotonin transporter binding after methamphetamine. Methamphetamine 104-119 solute carrier family 6 member 4 Rattus norvegicus 68-89 24959862-4 2014 We analyzed long-term, off-drug changes in learning from positive and negative feedback and associated striatal DA transporter (DAT) and frontocortical 5HT transporter (SERT) binding in rats pretreated with methamphetamine (mAMPH). Methamphetamine 207-222 solute carrier family 6 member 4 Rattus norvegicus 152-167 24959862-4 2014 We analyzed long-term, off-drug changes in learning from positive and negative feedback and associated striatal DA transporter (DAT) and frontocortical 5HT transporter (SERT) binding in rats pretreated with methamphetamine (mAMPH). Methamphetamine 207-222 solute carrier family 6 member 4 Rattus norvegicus 169-173 22183017-2 2012 Hence, in this paper Western-blot analysis was used to evaluate expression changes on them during memory formation in trained and untrained rats treated with the selective serotonin transporter inhibitor fluoxetine, the amnesic drug d-methamphetamine (METH) and fluoxetine plus METH. Methamphetamine 278-282 solute carrier family 6 member 4 Rattus norvegicus 172-193 22633984-7 2012 Fluoxetine plus METH administration was also able to prevent forgetting, which was associated to hippocampal DAT, prefrontal cortex SERT and striatal GAT1, DAT or SERT up-regulation, but prefrontal cortex GAT1 down-regulation. Methamphetamine 16-20 solute carrier family 6 member 4 Rattus norvegicus 132-136 22633984-7 2012 Fluoxetine plus METH administration was also able to prevent forgetting, which was associated to hippocampal DAT, prefrontal cortex SERT and striatal GAT1, DAT or SERT up-regulation, but prefrontal cortex GAT1 down-regulation. Methamphetamine 16-20 solute carrier family 6 member 4 Rattus norvegicus 163-167 22183017-10 2012 Fluoxetine plus METH administration was able to prevent amnesia, which was associated to DAT, EACC1 and GAT1 (prefrontal cortex), SERT and DAT (hippocampus) and EACC1 or DAT (striatal) up-regulation. Methamphetamine 16-20 solute carrier family 6 member 4 Rattus norvegicus 130-134 22115899-11 2012 While only acute meth binge produced signs of neurotoxicity, both meth regimens decreased SERT in the perirhinal cortex and hippocampus. Methamphetamine 66-70 solute carrier family 6 member 4 Rattus norvegicus 90-94 22115899-13 2012 Meth-induced changes in SERT function in the OIP circuitry may underlie memory deficits independently of overt neurotoxic effects. Methamphetamine 0-4 solute carrier family 6 member 4 Rattus norvegicus 24-28 22183017-8 2012 The METH-induced amnesia down-regulated SERT, DAT, EACC1 and GAT1 in hippocampus and the GAT1 in striatum; no-changes were observed in prefrontal cortex. Methamphetamine 4-8 solute carrier family 6 member 4 Rattus norvegicus 40-44 21643674-0 2012 Work aversion and associated changes in dopamine and serotonin transporter after methamphetamine exposure in rats. Methamphetamine 81-96 solute carrier family 6 member 4 Rattus norvegicus 53-74 21953518-8 2012 Also, mAMPH was found to reduce [(125) I]RTI-55 binding to serotonin transporters (SERT) in frontoparietal cortex, and this too was significantly attenuated by exercise. Methamphetamine 6-11 solute carrier family 6 member 4 Rattus norvegicus 59-81 21953518-8 2012 Also, mAMPH was found to reduce [(125) I]RTI-55 binding to serotonin transporters (SERT) in frontoparietal cortex, and this too was significantly attenuated by exercise. Methamphetamine 6-11 solute carrier family 6 member 4 Rattus norvegicus 83-87 16687477-5 2006 Pretreatment with the serotonin transporter inhibitor fluoxetine blocked both this acute effect on VMAT-2 and the decrease in serotonin content observed 7 days after METH treatment. Methamphetamine 166-170 solute carrier family 6 member 4 Rattus norvegicus 22-43 21159748-7 2011 In contrast, the Meth-induced decreases in striatal SERT immunoreactivity and vesicular 5-HT content were not affected by MLA. Methamphetamine 17-21 solute carrier family 6 member 4 Rattus norvegicus 52-56 10556503-1 1999 High-dose administrations of amphetamine, methamphetamine, cathinone, methcathinone or methylenedioxymethamphetamine rapidly decrease dopamine and serotonin transporter function in vivo, as assessed in striatal synaptosomes obtained from drug-treated rats. Methamphetamine 42-57 solute carrier family 6 member 4 Rattus norvegicus 147-168 15900317-8 2005 mAMPH-treated rats showed reductions in striatal DAT and hippocampal (HC) and perirhinal (pRh) SERT, as well as degeneration of neurons in primary somatosensory cortex. Methamphetamine 0-5 solute carrier family 6 member 4 Rattus norvegicus 95-99 10987842-1 2000 Multiple administrations of methamphetamine (METH) rapidly decreased serotonin (5HT) transporter (SERT) function in rat striatum and hippocampus. Methamphetamine 28-43 solute carrier family 6 member 4 Rattus norvegicus 98-102 10987842-1 2000 Multiple administrations of methamphetamine (METH) rapidly decreased serotonin (5HT) transporter (SERT) function in rat striatum and hippocampus. Methamphetamine 45-49 solute carrier family 6 member 4 Rattus norvegicus 98-102 10987842-2 2000 The purpose of this study was to identify the mechanisms/ factors contributing to this METH-induced decrease in SERT function. Methamphetamine 87-91 solute carrier family 6 member 4 Rattus norvegicus 112-116 10987842-7 2000 These results suggest that DA contributes to the decrease in SERT function caused by multiple METH injections in the striatum, but not hippocampus, and that hyperthermia facilitates these deficits in SERT function in both brain regions. Methamphetamine 94-98 solute carrier family 6 member 4 Rattus norvegicus 61-65 10987842-8 2000 In contrast, the response of SERT to a single administration of METH was DA and hyperthermia independent. Methamphetamine 64-68 solute carrier family 6 member 4 Rattus norvegicus 29-33 10987842-9 2000 These findings suggest that the mechanisms/ factors involved in decreasing SERT activity after a single administration of METH are distinct from that caused by multiple administrations. Methamphetamine 122-126 solute carrier family 6 member 4 Rattus norvegicus 75-79 7700252-3 1995 With 1-methyl-4-phenylpyridinium as a substrate for DAT and NET and serotonin as a substrate for the serotonin transporter, each transporter demonstrated a distinct pattern of inhibition by a panel of amphetamine derivatives and analogs, including amphetamine, methamphetamine (also known as "ecstasy"), p-chloroamphetamine, 3,4-methylenedioxymethamphetamine, methylphenidate (ritalin), and 5-methoxy-6-methyl-2-aminoindan. Methamphetamine 261-276 solute carrier family 6 member 4 Rattus norvegicus 101-122 31535286-0 2019 In vivo long-lasting alterations of central serotonin transporter activity and associated dopamine synthesis after acute repeated administration of methamphetamine. Methamphetamine 148-163 solute carrier family 6 member 4 Rattus norvegicus 44-65 31535286-1 2019 BACKGROUND: Methamphetamine (METH)-associated alterations in the striatal dopamine (DA) system or dopamine transport (DAT) have been identified in clinical and preclinical studies with positron emission tomography (PET) imaging but have not been well correlated with in vivo serotonin transporter (SERT) availability due to the lack of appropriate imaging agents to assess SERTs. Methamphetamine 12-27 solute carrier family 6 member 4 Rattus norvegicus 275-296 31535286-1 2019 BACKGROUND: Methamphetamine (METH)-associated alterations in the striatal dopamine (DA) system or dopamine transport (DAT) have been identified in clinical and preclinical studies with positron emission tomography (PET) imaging but have not been well correlated with in vivo serotonin transporter (SERT) availability due to the lack of appropriate imaging agents to assess SERTs. Methamphetamine 12-27 solute carrier family 6 member 4 Rattus norvegicus 298-302 31535286-1 2019 BACKGROUND: Methamphetamine (METH)-associated alterations in the striatal dopamine (DA) system or dopamine transport (DAT) have been identified in clinical and preclinical studies with positron emission tomography (PET) imaging but have not been well correlated with in vivo serotonin transporter (SERT) availability due to the lack of appropriate imaging agents to assess SERTs. Methamphetamine 29-33 solute carrier family 6 member 4 Rattus norvegicus 275-296 31535286-1 2019 BACKGROUND: Methamphetamine (METH)-associated alterations in the striatal dopamine (DA) system or dopamine transport (DAT) have been identified in clinical and preclinical studies with positron emission tomography (PET) imaging but have not been well correlated with in vivo serotonin transporter (SERT) availability due to the lack of appropriate imaging agents to assess SERTs. Methamphetamine 29-33 solute carrier family 6 member 4 Rattus norvegicus 298-302 31535286-3 2019 The aims of this study were to investigate the potential of SERT imaging using 4-[18F]-ADAM PET to estimate the long-lasting effects of METH-induced serotonergic neurotoxicity, and further determine whether a correlative relationship exists between SERT availability/activity and tyrosine hydroxylase (TH) activity in various brain regions due to the long-lasting consequences of METH treatment. Methamphetamine 136-140 solute carrier family 6 member 4 Rattus norvegicus 60-64 28035393-0 2017 Fluoxetine protects against methamphetamine-induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats. Methamphetamine 28-43 solute carrier family 6 member 4 Rattus norvegicus 114-118 28856500-7 2018 In contrast, EtOH drinking alone did not affect dopamine and serotonin content in the striatum and prefrontal cortex, but prior EtOH drinking followed by injections of Meth enhanced Meth-induced depletions of dopamine, serotonin, as well as dopamine and serotonin transporter immunoreactivities in a manner that was correlated with the degree of EtOH consumption. Methamphetamine 168-172 solute carrier family 6 member 4 Rattus norvegicus 254-275 28856500-7 2018 In contrast, EtOH drinking alone did not affect dopamine and serotonin content in the striatum and prefrontal cortex, but prior EtOH drinking followed by injections of Meth enhanced Meth-induced depletions of dopamine, serotonin, as well as dopamine and serotonin transporter immunoreactivities in a manner that was correlated with the degree of EtOH consumption. Methamphetamine 182-186 solute carrier family 6 member 4 Rattus norvegicus 254-275