PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20298714-0 2010 Methamphetamine-induced stereotypy correlates negatively with patch-enhanced prodynorphin and arc mRNA expression in the rat caudate putamen: the role of mu opioid receptor activation. Methamphetamine 0-15 prodynorphin Rattus norvegicus 77-89 20298714-2 2010 Methamphetamine (METH) treatment also induces patch-enhanced expression of prodynorphin (PD), arc and zif/268 in the CPu. Methamphetamine 0-15 prodynorphin Rattus norvegicus 75-87 20298714-2 2010 Methamphetamine (METH) treatment also induces patch-enhanced expression of prodynorphin (PD), arc and zif/268 in the CPu. Methamphetamine 17-21 prodynorphin Rattus norvegicus 75-87 12485404-0 2003 Distinct effects of methamphetamine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix. Methamphetamine 20-35 prodynorphin Rattus norvegicus 51-66 15680692-1 2005 Cocaine and methamphetamine (METH) induce preprodynorphin (PPD) mRNA expression in the striatum. Methamphetamine 12-27 prodynorphin Rattus norvegicus 42-57 15680692-1 2005 Cocaine and methamphetamine (METH) induce preprodynorphin (PPD) mRNA expression in the striatum. Methamphetamine 12-27 prodynorphin Rattus norvegicus 59-62 15680692-1 2005 Cocaine and methamphetamine (METH) induce preprodynorphin (PPD) mRNA expression in the striatum. Methamphetamine 29-33 prodynorphin Rattus norvegicus 42-57 15680692-1 2005 Cocaine and methamphetamine (METH) induce preprodynorphin (PPD) mRNA expression in the striatum. Methamphetamine 29-33 prodynorphin Rattus norvegicus 59-62 15680692-2 2005 Cocaine induces PPD expression in both the patch and matrix compartments of the rostral striatum, whereas METH induces PPD expression in the patch compartment of the rostral striatum. Methamphetamine 106-110 prodynorphin Rattus norvegicus 119-122 15680692-9 2005 Cocaine- and METH-induced PPD expression in the rostral patch compartment was unaffected by PCA-pretreatment. Methamphetamine 13-17 prodynorphin Rattus norvegicus 26-29 15680692-10 2005 PCA-pretreatment also decreased both cocaine- and METH-induced PPD expression in the matrix, but not patch of middle striatum. Methamphetamine 50-54 prodynorphin Rattus norvegicus 63-66 12485404-1 2003 We and others previously reported that equimolar doses of methamphetamine and cocaine differentially increase preprodynorphin mRNA in striatum: methamphetamine causes a patchy increase, whereas cocaine produces a more homogenous one. Methamphetamine 58-73 prodynorphin Rattus norvegicus 110-125 12485404-1 2003 We and others previously reported that equimolar doses of methamphetamine and cocaine differentially increase preprodynorphin mRNA in striatum: methamphetamine causes a patchy increase, whereas cocaine produces a more homogenous one. Methamphetamine 144-159 prodynorphin Rattus norvegicus 110-125 12485404-3 2003 In addition, we determined whether doses of cocaine (30 mg/kg) and methamphetamine (2 mg/kg) that produced equivalent increases in extracellular dopamine differentially affected preprodynorphin mRNA expression in striatum of male, Sprague-Dawley rats. Methamphetamine 67-82 prodynorphin Rattus norvegicus 178-193 12485404-4 2003 In both experiments, methamphetamine and cocaine differentially affected preprodynorphin mRNA in striatum after 3 h. The high, equimolar dose of methamphetamine selectively increased preprodynorphin mRNA in the patch division of rostral striatum, whereas cocaine increased preprodynorphin mRNA throughout patch and matrix divisions of striatum. Methamphetamine 21-36 prodynorphin Rattus norvegicus 73-88 12485404-4 2003 In both experiments, methamphetamine and cocaine differentially affected preprodynorphin mRNA in striatum after 3 h. The high, equimolar dose of methamphetamine selectively increased preprodynorphin mRNA in the patch division of rostral striatum, whereas cocaine increased preprodynorphin mRNA throughout patch and matrix divisions of striatum. Methamphetamine 21-36 prodynorphin Rattus norvegicus 183-198 12485404-4 2003 In both experiments, methamphetamine and cocaine differentially affected preprodynorphin mRNA in striatum after 3 h. The high, equimolar dose of methamphetamine selectively increased preprodynorphin mRNA in the patch division of rostral striatum, whereas cocaine increased preprodynorphin mRNA throughout patch and matrix divisions of striatum. Methamphetamine 21-36 prodynorphin Rattus norvegicus 183-198 12485404-4 2003 In both experiments, methamphetamine and cocaine differentially affected preprodynorphin mRNA in striatum after 3 h. The high, equimolar dose of methamphetamine selectively increased preprodynorphin mRNA in the patch division of rostral striatum, whereas cocaine increased preprodynorphin mRNA throughout patch and matrix divisions of striatum. Methamphetamine 145-160 prodynorphin Rattus norvegicus 73-88 12485404-4 2003 In both experiments, methamphetamine and cocaine differentially affected preprodynorphin mRNA in striatum after 3 h. The high, equimolar dose of methamphetamine selectively increased preprodynorphin mRNA in the patch division of rostral striatum, whereas cocaine increased preprodynorphin mRNA throughout patch and matrix divisions of striatum. Methamphetamine 145-160 prodynorphin Rattus norvegicus 183-198 12485404-4 2003 In both experiments, methamphetamine and cocaine differentially affected preprodynorphin mRNA in striatum after 3 h. The high, equimolar dose of methamphetamine selectively increased preprodynorphin mRNA in the patch division of rostral striatum, whereas cocaine increased preprodynorphin mRNA throughout patch and matrix divisions of striatum. Methamphetamine 145-160 prodynorphin Rattus norvegicus 183-198 11032895-1 2000 In general, administration of methamphetamine and cocaine alters preprodynorphin and preproenkephalin mRNA levels in striatum. Methamphetamine 30-45 prodynorphin Rattus norvegicus 65-80 11032895-3 2000 This study used in situ hybridization to compare directly the effects of cocaine and methamphetamine on preprodynorphin and preproenkephalin mRNAs in distinct striatal regions. Methamphetamine 85-100 prodynorphin Rattus norvegicus 104-119 11032895-5 2000 Methamphetamine and cocaine differentially affected preprodynorphin mRNA in striatum after 3 h. Densitometric analysis of film autoradiograms revealed that cocaine, but not methamphetamine, significantly increased preprodynorphin. Methamphetamine 0-15 prodynorphin Rattus norvegicus 52-67 11032895-5 2000 Methamphetamine and cocaine differentially affected preprodynorphin mRNA in striatum after 3 h. Densitometric analysis of film autoradiograms revealed that cocaine, but not methamphetamine, significantly increased preprodynorphin. Methamphetamine 0-15 prodynorphin Rattus norvegicus 214-229 11032895-7 2000 However, specific analysis of "patches" in which preprodynorphin expression is high revealed a significantly greater effect of methamphetamine versus cocaine. Methamphetamine 127-142 prodynorphin Rattus norvegicus 49-64 9988101-0 1999 Methamphetamine alters prodynorphin gene expression and dynorphin A levels in rat hypothalamus. Methamphetamine 0-15 prodynorphin Rattus norvegicus 23-35 9988101-2 1999 To better understand the possible existence of common neuronal pathways shared by different classes of drugs of abuse, we studied the effects of methamphetamine on the gene expression of the opioid precursor prodynorphin and on the levels of peptide dynorphin A in the rat brain. Methamphetamine 145-160 prodynorphin Rattus norvegicus 208-220 9988101-5 1999 for 15 days) methamphetamine markedly raised prodynorphin mRNA levels in the hypothalamus, whereas no effect was observed in the hippocampus. Methamphetamine 13-28 prodynorphin Rattus norvegicus 45-57 9988101-7 1999 These results indicate that methamphetamine affects prodynorphin gene expression in the hypothalamus, which may be an important site (also for its relevant neuroendocrine correlates) for opioidergic mechanisms activated by addictive drugs. Methamphetamine 28-43 prodynorphin Rattus norvegicus 52-64 9138744-0 1996 Acute methamphetamine-induced zif/268, preprodynorphin, and preproenkephalin mRNA expression in rat striatum depends on activation of NMDA and kainate/AMPA receptors. Methamphetamine 6-21 prodynorphin Rattus norvegicus 39-54 8787127-0 1996 D1 and D2 receptor regulation of preproenkephalin and preprodynorphin mRNA in rat striatum following acute injection of amphetamine or methamphetamine. Methamphetamine 135-150 prodynorphin Rattus norvegicus 54-69 8787127-1 1996 Our previous work has demonstrated a dose-dependent induction of striatal preprodynorphin (PPD) in response to a single injection of the psychostimulants amphetamine (AMPH) or methamphetamine (METH). Methamphetamine 176-191 prodynorphin Rattus norvegicus 74-89 8787127-1 1996 Our previous work has demonstrated a dose-dependent induction of striatal preprodynorphin (PPD) in response to a single injection of the psychostimulants amphetamine (AMPH) or methamphetamine (METH). Methamphetamine 193-197 prodynorphin Rattus norvegicus 74-89 9138744-6 1996 Furthermore, both antagonists caused a parallel blockade of methamphetamine-stimulated preprodynorphin mRNA expression in the dorsal and ventral striatum but did not significantly affect methamphetamine-stimulated preproenkephalin mRNA expression. Methamphetamine 60-75 prodynorphin Rattus norvegicus 87-102 7477938-0 1995 A single injection of amphetamine or methamphetamine induces dynamic alterations in c-fos, zif/268 and preprodynorphin messenger RNA expression in rat forebrain. Methamphetamine 37-52 prodynorphin Rattus norvegicus 103-118 7477938-7 1995 However, in the striatal regions, zif/268 messenger RNA levels peaked at 1 h and declined gradually to basal levels by 6 h. Interestingly, methamphetamine caused an actual suppression of zif/268 gene expression (> 50%) in both caudatoputamen and nucleus accumbens at 3 h. Preprodynorphin messenger RNA expression was increased in a patchy motif in the caudatoputamen and nucleus accumbens beginning at 2 h and returning to basal levels by 30 h after injection of either drug. Methamphetamine 139-154 prodynorphin Rattus norvegicus 275-290 7477938-8 1995 This study, together with our recently published observation that preprodynorphin messenger RNA is induced in the caudate 3, 6 and 18 h after amphetamine or methamphetamine injection, provides a detailed dynamic description of the differential modulation of c-fos, zif/268 and preprodynorphin messenger RNA expression in the cerebral cortex and striatum by amphetamines over time. Methamphetamine 157-172 prodynorphin Rattus norvegicus 66-81 7477938-9 1995 These data implicate immediate early gene and preprodynorphin gene expression in the differential response of medium spiny striatal neurons to methamphetamine and amphetamine. Methamphetamine 143-158 prodynorphin Rattus norvegicus 46-61 7752096-0 1995 Dose-dependent alteration in zif/268 and preprodynorphin mRNA expression induced by amphetamine or methamphetamine in rat forebrain. Methamphetamine 99-114 prodynorphin Rattus norvegicus 41-56 7752096-1 1995 The dose-related effects of a single injection of D-amphetamine (AMPH) or methamphetamine (METH) on the mRNA expression of the immediate early gene zif/268 and the opioid peptide preprodynorphin, in rat forebrain, were investigated with quantitative in situ hybridization histochemistry 3 h after injection. Methamphetamine 74-89 prodynorphin Rattus norvegicus 179-194 7752096-1 1995 The dose-related effects of a single injection of D-amphetamine (AMPH) or methamphetamine (METH) on the mRNA expression of the immediate early gene zif/268 and the opioid peptide preprodynorphin, in rat forebrain, were investigated with quantitative in situ hybridization histochemistry 3 h after injection. Methamphetamine 91-95 prodynorphin Rattus norvegicus 179-194 7752096-8 1995 These results demonstrate a clear dose-related responsiveness of zif/268 and preprodynorphin gene expression in cortical and/or striatal neurons that is positively correlated with a dose-dependent motor-stimulating effect of AMPH and METH. Methamphetamine 234-238 prodynorphin Rattus norvegicus 77-92 27841313-0 2016 Increased expression of proenkephalin and prodynorphin mRNAs in the nucleus accumbens of compulsive methamphetamine taking rats. Methamphetamine 100-115 prodynorphin Rattus norvegicus 42-54 27841313-10 2016 Because PDYN and PENK are expressed in dopamine D1- and D2-containing NAc neurons, respectively, these findings suggest that mechanisms, which impact both cell types may play a role in the regulation of compulsive methamphetamine taking by rats. Methamphetamine 214-229 prodynorphin Rattus norvegicus 8-12