PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2882825-1 1987 Long-term treatment of rats with methamphetamine (20 mg/kg, IP, every 12 hours for 10 days) resulted in a large decrease in tyrosine hydroxylase staining axons and terminal boutons in the nucleus accumbens and frontal cortex, as well as the ventral tegmental area of the midbrain, when examined 60 days following termination of the drug treatment regimen. Methamphetamine 33-48 tyrosine hydroxylase Rattus norvegicus 124-144 12105086-2 2002 Tyrosine hydroxylase (TH), the rate-limiting enzyme of the synthetic pathway of catecholamines, is a good marker to assess potential effects of Meth in catecholaminergic (particularly in dopaminergic) systems. Methamphetamine 144-148 tyrosine hydroxylase Rattus norvegicus 0-20 12105086-2 2002 Tyrosine hydroxylase (TH), the rate-limiting enzyme of the synthetic pathway of catecholamines, is a good marker to assess potential effects of Meth in catecholaminergic (particularly in dopaminergic) systems. Methamphetamine 144-148 tyrosine hydroxylase Rattus norvegicus 22-24 12105086-3 2002 In the rat, prolonged neonatal Meth exposure altered several dopaminergic markers (TH activity and gene expression) in substantia nigra pars compacta (SN) and in caudate-putamen (TH activity) when animals matured. Methamphetamine 31-35 tyrosine hydroxylase Rattus norvegicus 83-85 12105086-3 2002 In the rat, prolonged neonatal Meth exposure altered several dopaminergic markers (TH activity and gene expression) in substantia nigra pars compacta (SN) and in caudate-putamen (TH activity) when animals matured. Methamphetamine 31-35 tyrosine hydroxylase Rattus norvegicus 179-181 12105086-4 2002 However, it was never verified whether gestational exposure to Meth might compromise TH enzyme in the pups during the neonatal immature periods. Methamphetamine 63-67 tyrosine hydroxylase Rattus norvegicus 85-87 12105086-10 2002 Meth treatment differentially affected TH mRNA levels in VTA and SN, in an age- and gender-dependent manner. Methamphetamine 0-4 tyrosine hydroxylase Rattus norvegicus 39-41 12105086-11 2002 Thus, TH mRNA levels were decreased in the VTA of PND 7 and PND 14 females gestationally exposed to Meth; this effect was not evident in males or on PND 30. Methamphetamine 100-104 tyrosine hydroxylase Rattus norvegicus 6-8 12105086-12 2002 TH mRNA levels also tend to decrease in SN of PND 14 females gestationally exposed to Meth. Methamphetamine 86-90 tyrosine hydroxylase Rattus norvegicus 0-2 12105086-13 2002 Collectively, the present results indicated that gestational Meth exposure affects TH gene expression in the postnatal life, a phenomenon that appears to be transient, since it is no longer evident by the end of the first month of life in the rat. Methamphetamine 61-65 tyrosine hydroxylase Rattus norvegicus 83-85 9353379-1 1997 Methamphetamine (METH), administered in large, repeated doses, compromises the dopaminergic and serotonergic systems as indicated by prolonged suppression of tyrosine hydroxylase and tryptophan hydroxylase activity and concurrent decreases in the content of dopamine and 5-hydroxytryptamine. Methamphetamine 0-15 tyrosine hydroxylase Rattus norvegicus 158-178 9353379-1 1997 Methamphetamine (METH), administered in large, repeated doses, compromises the dopaminergic and serotonergic systems as indicated by prolonged suppression of tyrosine hydroxylase and tryptophan hydroxylase activity and concurrent decreases in the content of dopamine and 5-hydroxytryptamine. Methamphetamine 17-21 tyrosine hydroxylase Rattus norvegicus 158-178 8959049-0 1996 Neurochemical analysis of the tyrosine hydroxylase expression in methamphetamine-sensitized rats. Methamphetamine 65-80 tyrosine hydroxylase Rattus norvegicus 30-50 10564366-4 1999 In the present study we establish that after unilateral 6-hydroxydopamine lesions or methamphetamine administration, striatal TH-immunoreactive neurons differ in size, morphology and location from those that are immunopositive for AADC or dopamine. Methamphetamine 85-100 tyrosine hydroxylase Rattus norvegicus 126-128 2882825-3 1987 Thus, tyrosine hydroxylase enzyme in both the cell bodies of the midbrain ventral tegmental area as well as in the nerve terminals in post-synaptic target regions of the forebrain is depleted by chronic methamphetamine administration. Methamphetamine 203-218 tyrosine hydroxylase Rattus norvegicus 6-26 25535855-9 2015 Methamphetamine significantly elevated core body temperature in males and decreased striatal DAT and TH content, and this effect was potentiated by early life stress. Methamphetamine 0-15 tyrosine hydroxylase Rattus norvegicus 101-103 6286-0 1976 Influence of methamphetamine on nigral and striatal tyrosine hydroxylase activity and on striatal dopamine levels. Methamphetamine 13-28 tyrosine hydroxylase Rattus norvegicus 52-72 6286-1 1976 In previous reports, methamphetamine was shown to depress tyrosine hydroxylase (TH) activity in the rat corpus striatum. Methamphetamine 21-36 tyrosine hydroxylase Rattus norvegicus 58-78 6286-1 1976 In previous reports, methamphetamine was shown to depress tyrosine hydroxylase (TH) activity in the rat corpus striatum. Methamphetamine 21-36 tyrosine hydroxylase Rattus norvegicus 80-82 6286-3 1976 Following repeated doses of methamphetamine, nigral TH activity decreased and reached 45% of controls at 12 hr and returned to normal at 60 hr. Methamphetamine 28-43 tyrosine hydroxylase Rattus norvegicus 52-54 6286-5 1976 When methamphetamine was administered every 6 hr for 30 hr and then discontinued, nigral TH activity returned toward control levels 4 days prior to recovery of striatal TH activity. Methamphetamine 5-20 tyrosine hydroxylase Rattus norvegicus 89-91 6286-5 1976 When methamphetamine was administered every 6 hr for 30 hr and then discontinued, nigral TH activity returned toward control levels 4 days prior to recovery of striatal TH activity. Methamphetamine 5-20 tyrosine hydroxylase Rattus norvegicus 169-171 6120843-5 1981 The data are discussed in the context of the effects of single versus repeated doses of methamphetamine on tryptophan and tyrosine hydroxylase. Methamphetamine 88-103 tyrosine hydroxylase Rattus norvegicus 122-142 6286-8 1976 Concurrent administration of chlorpromazine with methamphetamine prevented the methamphetamine-induced decrease in nigral and striatal TH activity and striatal dopamine levels. Methamphetamine 49-64 tyrosine hydroxylase Rattus norvegicus 135-137 6286-8 1976 Concurrent administration of chlorpromazine with methamphetamine prevented the methamphetamine-induced decrease in nigral and striatal TH activity and striatal dopamine levels. Methamphetamine 79-94 tyrosine hydroxylase Rattus norvegicus 135-137 6286-9 1976 The results indicate that the methamphetamine-induced depression of striatal and nigral TH activity may be related to increased stimulation of dopamine receptors in the striatum. Methamphetamine 30-45 tyrosine hydroxylase Rattus norvegicus 88-90 28661099-6 2017 The aim of this study was to determine whether self-administered METH altered the levels of alpha-synuclein, parkin, tyrosine hydroxylase (TH), and dopamine-beta-hydroxylase (DbetaH) in the myenteric plexus of the distal colon ENS. Methamphetamine 65-69 tyrosine hydroxylase Rattus norvegicus 117-137 28661099-9 2017 Levels of alpha-synuclein were increased, while levels of parkin, TH, and DbetaH were decreased in the myenteric plexus in the METH-exposed rats at 1 day following the last operant session and returned to the control levels after 14 or 56 days of forced abstinence. Methamphetamine 127-131 tyrosine hydroxylase Rattus norvegicus 66-68 21523347-1 2011 RATIONALE: Methamphetamine (MA) increases extracellular dopamine (DA) and at chronic high doses induces toxicity as indicated by decreased expression of tyrosine hydroxylase (TH) and dopamine transporter (DAT). Methamphetamine 11-26 tyrosine hydroxylase Rattus norvegicus 153-173 21953518-6 2012 Binge mAMPH treatment significantly reduced striatal DAT and TH in a regionally specific pattern; with greatest effects in ventral caudate-putamen (CP) and relative sparing of the nucleus accumbens septi (NAc). Methamphetamine 6-11 tyrosine hydroxylase Rattus norvegicus 61-63 21953518-7 2012 The effects of mAMPH on striatal DAT and TH were ameliorated in the running, compared to the sedentary, animals. Methamphetamine 15-20 tyrosine hydroxylase Rattus norvegicus 41-43 23313192-10 2013 In METH-exposed rats, the increase in parkin levels attenuated METH-induced decreases in striatal tyrosine hydroxylase immunoreactivity in a dose-dependent manner, indicating that parkin can protect striatal dopaminergic terminals against METH neurotoxicity. Methamphetamine 3-7 tyrosine hydroxylase Rattus norvegicus 98-118 23313192-10 2013 In METH-exposed rats, the increase in parkin levels attenuated METH-induced decreases in striatal tyrosine hydroxylase immunoreactivity in a dose-dependent manner, indicating that parkin can protect striatal dopaminergic terminals against METH neurotoxicity. Methamphetamine 63-67 tyrosine hydroxylase Rattus norvegicus 98-118 23313192-10 2013 In METH-exposed rats, the increase in parkin levels attenuated METH-induced decreases in striatal tyrosine hydroxylase immunoreactivity in a dose-dependent manner, indicating that parkin can protect striatal dopaminergic terminals against METH neurotoxicity. Methamphetamine 63-67 tyrosine hydroxylase Rattus norvegicus 98-118 21523347-1 2011 RATIONALE: Methamphetamine (MA) increases extracellular dopamine (DA) and at chronic high doses induces toxicity as indicated by decreased expression of tyrosine hydroxylase (TH) and dopamine transporter (DAT). Methamphetamine 11-26 tyrosine hydroxylase Rattus norvegicus 175-177 17239369-2 2007 In addition to the severe behavioral and societal consequences associated with methamphetamine abuse, methamphetamine can cause persistent damage to monoaminergic nerve terminals in rats, as measured by either monoamine concentrations or activity of the rate limiting synthetic enzymes, tyrosine hydroxylase and tryptophan hydroxylase. Methamphetamine 102-117 tyrosine hydroxylase Rattus norvegicus 287-307