PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33920736-0 2021 Antitumor Activity of Pulvomycin via Targeting Activated-STAT3 Signaling in Docetaxel-Resistant Triple-Negative Breast Cancer Cells. pulvomycin 22-32 signal transducer and activator of transcription 3 Mus musculus 57-62 33920736-4 2021 In this study, a docetaxel-resistant TNBC cell line (MDA-MB-231-DTR) was established, and mechanisms for the antitumor activity of pulvomycin, a novel STAT3 inhibitor isolated from marine-derived actinomycete, were investigated. pulvomycin 131-141 signal transducer and activator of transcription 3 Mus musculus 151-156 33920736-7 2021 In addition, pulvomycin suppressed the activation of STAT3 and subsequently induced G0/G1 cell cycle arrest and apoptosis. pulvomycin 13-23 signal transducer and activator of transcription 3 Mus musculus 53-58 33920736-9 2021 In an MDA-MB-231-DTR-bearing xenograft mouse model, the combination of pulvomycin and docetaxel effectively inhibited tumor growth through STAT3 regulation. pulvomycin 71-81 signal transducer and activator of transcription 3 Mus musculus 139-144