PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15940365-13 2005 Pretreatment of cells with alpha-LA prevented these changes induced by TNF-alpha and H2O2. Thioctic Acid 27-35 tumor necrosis factor Homo sapiens 71-80 16632109-0 2006 Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumor necrosis factor-alpha. Thioctic Acid 12-29 tumor necrosis factor Homo sapiens 215-242 17334234-3 2007 ALA inhibited high-glucose- and TNF-alpha-stimulated VSMC migrations in vitro. Thioctic Acid 0-3 tumor necrosis factor Homo sapiens 14-41 15940365-0 2005 Alpha-lipoic acid inhibits TNF-alpha-induced apoptosis in human bone marrow stromal cells. Thioctic Acid 0-17 tumor necrosis factor Homo sapiens 27-36 15940365-3 2005 alpha-Lipoic acid prevented these changes induced by TNF-alpha and H2O2, suggesting its potential therapeutic applications in attenuating bone loss. Thioctic Acid 0-17 tumor necrosis factor Homo sapiens 53-62 15940365-7 2005 We also examined the protective effects of an important biological thiol antioxidant, alpha-lipoic acid (alpha-LA), against TNF-alpha- and H2O2-induced apoptosis. Thioctic Acid 86-103 tumor necrosis factor Homo sapiens 124-133 15940365-7 2005 We also examined the protective effects of an important biological thiol antioxidant, alpha-lipoic acid (alpha-LA), against TNF-alpha- and H2O2-induced apoptosis. Thioctic Acid 105-113 tumor necrosis factor Homo sapiens 124-133 15378733-7 2004 Proteins up-regulated by TNFalpha that were subsequently down-regulated in the presence of ALA were identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry as plasminogen activator inhibitor-2, fetal liver LKB-interacting protein, osteoblast-specific factor 2, glucosidase II, cyclin-dependent kinase 3, endoplasmin precursor and glutathione synthetase. Thioctic Acid 91-94 tumor necrosis factor Homo sapiens 25-33 15378733-8 2004 TNFalpha down-regulated proteins that were up-regulated in the presence of ALA were keratin 19, eukaryotic translation elongation factor and Rho GDP dissociation inhibitor alpha. Thioctic Acid 75-78 tumor necrosis factor Homo sapiens 0-8 15378733-9 2004 Gene expression analysis using DNA microarray tools confirmed the up-regulation or down-regulation of some, but not all, of the proteins observed in ALA challenged, TNFalpha-treated cells. Thioctic Acid 149-152 tumor necrosis factor Homo sapiens 165-173 12800192-6 2003 The antioxidants N-acetylcysteine, reduced glutathione, lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on TNFalpha-induced caspase activation. Thioctic Acid 56-67 tumor necrosis factor Homo sapiens 142-150 15033766-3 2003 The antioxidants N-acetylcysteine, glutathione, lipoic acid, and ascorbic acid markedly reduced the effect of the hormone on TNF-induced caspase activation, attesting to the involvement of reactive oxygen species (ROS) in the cross-talk between the hormone and the cytokine. Thioctic Acid 48-59 tumor necrosis factor Homo sapiens 125-128 11689467-0 2001 Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells. Thioctic Acid 0-17 tumor necrosis factor Homo sapiens 27-36 11689467-3 2001 We investigated the role of (R)-alpha-lipoic acid (LA) vs. glutathione and ascorbic acid in tumor necrosis factor alpha (TNF-alpha) -induced adhesion molecule expression and nuclear factor kappaB (NF-kappaB) signaling in human aortic endothelial cells (HAEC). Thioctic Acid 28-49 tumor necrosis factor Homo sapiens 92-119 11689467-3 2001 We investigated the role of (R)-alpha-lipoic acid (LA) vs. glutathione and ascorbic acid in tumor necrosis factor alpha (TNF-alpha) -induced adhesion molecule expression and nuclear factor kappaB (NF-kappaB) signaling in human aortic endothelial cells (HAEC). Thioctic Acid 28-49 tumor necrosis factor Homo sapiens 121-130 1482376-5 1992 Incubation of Jurkat T cells (1 x 10(6) cells/ml) with a natural thiol antioxidant, alpha-lipoic acid, prior to the stimulation of cells was found to inhibit NF-kappa B activation induced by tumor necrosis factor-alpha (25 ng/ml) or by phorbol 12-myristate 13-acetate (50 ng/ml). Thioctic Acid 84-101 tumor necrosis factor Homo sapiens 191-218 11928721-7 2002 Pretreatment with antioxidants, pyrrolidine dithiocarbamate and alpha-lipoic acid, both of which are known to be suppressors of NF-kappaB activation, effectively attenuated basal and TNF-alpha-induced ET-1 release. Thioctic Acid 64-81 tumor necrosis factor Homo sapiens 183-192 11772527-4 2002 Both vitamin E and vitamin C had no effect on ICAM-1 expression at the doses used, but ALA reduced the TNF-alpha-stimulated ICAM-1 expression in a dose-dependent manner, to levels observed in unstimulated cells. Thioctic Acid 87-90 tumor necrosis factor Homo sapiens 103-112 34804428-15 2021 SB203580, PDTC, and alpha-LA reversed the effects of chemerin, reducing IL-6, TNF-alpha, NF-kappaB p-p65, and TGF-beta expression. Thioctic Acid 20-28 tumor necrosis factor Homo sapiens 78-87 34719371-5 2021 In particular, ALA is able to reduce inflammasome activity, the pro-inflammatory cytokine levels, such as TNF-alpha, IL-1beta, IL-6, IL-18 and IL-17, interferon (INF)-gamma as well as the production of Vascular and Intercellular cell adhesion protein (VCAM-1 and ICAM-1). Thioctic Acid 15-18 tumor necrosis factor Homo sapiens 106-115 34118221-9 2021 Furthermore, paracrine release of several growth factors like hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha), and insulin growth factor (IGF) reinforced the improved response of primary hepatocytes against CCl4 induced hepatotoxicity in the presence of ALA primed ADSCs. Thioctic Acid 342-345 tumor necrosis factor Homo sapiens 159-186 34118221-9 2021 Furthermore, paracrine release of several growth factors like hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha), and insulin growth factor (IGF) reinforced the improved response of primary hepatocytes against CCl4 induced hepatotoxicity in the presence of ALA primed ADSCs. Thioctic Acid 342-345 tumor necrosis factor Homo sapiens 188-196 35596774-8 2022 At the end of the chemotherapy cycles, ALA resulted in significant decline in serum levels of BNP, TNF-alpha, MDA, and neurotensin (p < 0.05) as compared to baseline data and placebo. Thioctic Acid 39-42 tumor necrosis factor Homo sapiens 99-108 32792069-3 2020 alpha-Lipoic-acid (LA) blocks TNFalpha and thrombin, as well as GMCSF-induced weakening. Thioctic Acid 0-17 tumor necrosis factor Homo sapiens 30-38 35442486-7 2022 After the intervention, as compared to the control group, ALA group showed significant reductions in serum levels of hs-CRP, TNF-alpha, 8-OHdG (p<0.001), urea, and BUN (p=0.029) with significant elevations in Hb concentration (p<0.001), serum iron (p=0.037) and transferrin saturation (p<0.001). Thioctic Acid 58-61 tumor necrosis factor Homo sapiens 125-134 34041950-8 2021 Furthermore, there were significant positive correlations among TNFalpha, ICAM-1, and PGRN levels both before and after ALA treatment. Thioctic Acid 120-123 tumor necrosis factor Homo sapiens 64-72 33827267-2 2021 This systematic review and dose-response meta-analysis of randomized controlled trials was performed to summarize the effects of ALA supplementation on inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in adults. Thioctic Acid 129-132 tumor necrosis factor Homo sapiens 261-270 33827267-10 2021 The findings of the meta-analysis showed that ALA supplementation significantly reduced CRP (WMD: -0.69 mg/L, 95% CI: -1.13, -0.26, P=0.002), IL-6 (WMD: -1.83 pg/ml, 95% CI: -2.90, -0.76, P=0.001), and TNF-alpha concentrations (WMD: -0.45 pg/ml, 95% CI: -0.85, -0.04, P=0.032). Thioctic Acid 46-49 tumor necrosis factor Homo sapiens 202-211 32373498-8 2020 Results: After 3 weeks, treatment of patients with ALA led to a significant decrease in tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) levels (P=0.01) compared to baseline. Thioctic Acid 51-54 tumor necrosis factor Homo sapiens 88-115 32373498-8 2020 Results: After 3 weeks, treatment of patients with ALA led to a significant decrease in tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) levels (P=0.01) compared to baseline. Thioctic Acid 51-54 tumor necrosis factor Homo sapiens 117-126 30721699-3 2019 Our objective in this meta-analysis was to conduct a systematic review and meta-analysis on randomized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor-alpha (TNF-alpha), c-reactive protein (CRP), and interleukin-6 (IL-6). Thioctic Acid 133-136 tumor necrosis factor Homo sapiens 199-226 32259774-6 2020 RESULTS: ALA treatment group had a significant reduction of the weight, BMI, MDA, TNF-alpha, and leptin levels but a significant increase of adiponectin level (P < 0.05) compared to the control group. Thioctic Acid 9-12 tumor necrosis factor Homo sapiens 82-91 32341698-7 2020 Analysis of the investigated parameters in the leading group after receiving alpha-lipoic acid for 4 months showed a significant decrease in the concentration of C-Reactive Protein, IL-6 and TNF-alpha. Thioctic Acid 77-94 tumor necrosis factor Homo sapiens 191-200 31885820-9 2019 Moreover, alpha-LA has mechanisms of epigenetic regulation in genes related to the expression of various inflammatory mediators, such PGE2, COX-2, iNOS, TNF-alpha, IL-1beta, and IL-6. Thioctic Acid 10-18 tumor necrosis factor Homo sapiens 153-162 31790890-11 2020 A significant difference in nicotinamide adenine dinucleotide phosphate oxidase 2 concentrations was observed between T0 and T2 only in ADPKD patients treated with ALA (P = 0.039, P = 0.039; respectively), although we did not find a significant difference in interleukin-6, interleukin -1beta, and tumor necrosis factor-alpha concentrations in either group. Thioctic Acid 164-167 tumor necrosis factor Homo sapiens 298-325 30721699-3 2019 Our objective in this meta-analysis was to conduct a systematic review and meta-analysis on randomized controlled trials to indicate ALA effects on serum inflammatory mediators concentration such as tumor necrosis factor-alpha (TNF-alpha), c-reactive protein (CRP), and interleukin-6 (IL-6). Thioctic Acid 133-136 tumor necrosis factor Homo sapiens 228-237 28366867-8 2017 5muM Cd2+ exposure significantly augmented nuclear Nrf2, GSH and GCLC, GCLM, HMOX1, TNFalpha and IL-6 mRNA expression but not GSR, however these upsurges were significantly abrogated by ALA or 1muM Cd2+ pre-treatments. Thioctic Acid 186-189 tumor necrosis factor Homo sapiens 84-92 30055672-5 2018 alpha-lipoic acid (LA), an over-the-counter dietary supplement, has also been previously shown to inhibit TNF and thrombin induced FM weakening. Thioctic Acid 0-17 tumor necrosis factor Homo sapiens 106-109 30096293-0 2018 Alpha-lipoic acid, but not di-hydrolipoic acid, activates Nrf2 response in primary human umbilical-vein endothelial cells and protects against TNF-alpha induced endothelium dysfunction. Thioctic Acid 0-17 tumor necrosis factor Homo sapiens 143-152 30096293-7 2018 In this study, we demonstrate that nmolar concentrations of oxidized alpha-lipoic acid, but not dehydrolipoic acid, protect human umbilical primary endothelial cells (HUVEC) from TNF-alpha induced dysfunction, inhibit NF-kappaB activation and block apoptosis following the activation of Nrf2 transcription factor. Thioctic Acid 69-86 tumor necrosis factor Homo sapiens 179-188 29930690-8 2018 Conclusion: In summary, the current meta-analysis demonstrated the promising impact of ALA administration on decreasing inflammatory markers such as CRP, IL-6 and TNF-alpha among patients with MetS and related disorders. Thioctic Acid 87-90 tumor necrosis factor Homo sapiens 163-172 25673508-7 2015 Furthermore, alpha-LA dose dependently decreased oxidative stress by a reduction in level of LPO, and the dose of 1000 microM indicates a significant decrease (p < 0.01) in TNF-alpha level. Thioctic Acid 13-21 tumor necrosis factor Homo sapiens 176-185 26721419-11 2016 Moreover, alpha-LA was able to abolish the stimulatory effects of the pro-inflammatory cytokine TNF-alpha on chemerin secretion. Thioctic Acid 10-18 tumor necrosis factor Homo sapiens 96-105 26765462-6 2016 Tumor necrosis factor (TNF)alpha-induced mRNA expressions of ICAM-1, IL-6, MCP-1, and RANTES were inhibited by ALA treatment. Thioctic Acid 111-114 tumor necrosis factor Homo sapiens 0-21 26765462-6 2016 Tumor necrosis factor (TNF)alpha-induced mRNA expressions of ICAM-1, IL-6, MCP-1, and RANTES were inhibited by ALA treatment. Thioctic Acid 111-114 tumor necrosis factor Homo sapiens 23-32 27238715-12 2016 The dietary supplement alpha-lipoic acid and progestogens (P4, MPA and 17alpha-hydroxyprogesterone) have been shown to inhibit both TNF and Thrombin induced FM weakening. Thioctic Acid 23-40 tumor necrosis factor Homo sapiens 132-135 24172699-11 2013 Alpha-lipoic acid significantly increased glutathione level and significantly decreased MDA, NO, TNF-alpha, Fas-L, MMP-2, troponin-I levels, and TGF-beta gene expression. Thioctic Acid 0-17 tumor necrosis factor Homo sapiens 97-106 23360079-0 2014 Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-alpha and EGF production in chronic leg wound healing. Thioctic Acid 11-28 tumor necrosis factor Homo sapiens 111-120 23599020-4 2013 alpha-LA treatment significantly increased tumor cell response to various apoptotic stresses, such as etoposide, 5-fluorouracil, UVC, gamma-irradiation, hypoxia, and tumor necrosis factor alpha (TNFalpha). Thioctic Acid 0-8 tumor necrosis factor Homo sapiens 166-193 23599020-4 2013 alpha-LA treatment significantly increased tumor cell response to various apoptotic stresses, such as etoposide, 5-fluorouracil, UVC, gamma-irradiation, hypoxia, and tumor necrosis factor alpha (TNFalpha). Thioctic Acid 0-8 tumor necrosis factor Homo sapiens 195-203 24729102-0 2014 Effects of alpha lipoic acid supplementation on serum levels of IL-8 and TNF-alpha in patient with ESRD undergoing hemodialysis. Thioctic Acid 11-28 tumor necrosis factor Homo sapiens 73-82 23599020-9 2013 Finally, we found that alpha-LA exerts an inhibitory effect on the nuclear translocation of NF-kappaB triggered by TNFalpha. Thioctic Acid 23-31 tumor necrosis factor Homo sapiens 115-123 19109223-0 2009 Alpha-lipoic acid inhibits tumor necrosis factor-induced remodeling and weakening of human fetal membranes. Thioctic Acid 0-17 tumor necrosis factor Homo sapiens 27-48 24489443-5 2013 Finally, by investigating the intracellular pathways involved in promoting the VEC release of cytokines/chemokines, which are targeted by natural anti-inflammatory compounds, we documented that alphaLipoic acid significantly counteracted TNF-alpha-induced NF-kappaB and p38/MAPK activation while the effects of Ginkgo biloba appeared to be predominantly mediated by Akt. Thioctic Acid 194-210 tumor necrosis factor Homo sapiens 238-247 23044303-12 2012 After antioxidant treatment using lipoic acid, levels of chemerin, apelin, TNF-alpha and 8-iso-PGF2alpha were further significantly decreased (P < 0.05). Thioctic Acid 34-45 tumor necrosis factor Homo sapiens 75-84 20709392-4 2010 Additionally, we have reported that the antioxidant and NFkappaB inhibitor alpha-lipoic Acid (LA) blocks these TNF-induced effects. Thioctic Acid 75-92 tumor necrosis factor Homo sapiens 111-114 19109223-10 2009 Lipoic acid inhibited these TNF-induced effects. Thioctic Acid 0-11 tumor necrosis factor Homo sapiens 28-31 19109223-11 2009 Lipoic acid pretreatment also inhibited TNF- and IL1B-induced increases in MMP9 protein activity and release in amnion epithelial cells, as well as PGE(2) increases in both amnion epithelial and mesenchymal cells. Thioctic Acid 0-11 tumor necrosis factor Homo sapiens 40-43 19109223-12 2009 In summary, lipoic acid pretreatment inhibited TNF-induced weakening of FM and cytokine-induced MMP9 and PGE(2) in both intact FM and amnion cells. Thioctic Acid 12-23 tumor necrosis factor Homo sapiens 47-50 18275839-7 2008 N-Acetylcysteine and alpha-lipoic acid inhibited TNFalpha-induced oxidant increase but did not affect NF-kappaB activation. Thioctic Acid 21-38 tumor necrosis factor Homo sapiens 49-57 18182252-0 2008 Alpha-lipoic acid inhibits TNF-alpha induced NF-kappa B activation through blocking of MEKK1-MKK4-IKK signaling cascades. Thioctic Acid 0-17 tumor necrosis factor Homo sapiens 27-36 18182252-6 2008 TNF-alpha induced IKK mediated phosphorylation of GST-I kappa B and pre-treatment with alpha-LA inhibited this pathway. Thioctic Acid 87-95 tumor necrosis factor Homo sapiens 0-9