PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28848097-0	2017	Alpha-Lipoic Acid Suppresses Extracellular Histone-Induced Release of the Infammatory Mediator Tumor Necrosis Factor-alpha by Macrophages.	Thioctic Acid	0-17	tumor necrosis factor	Mus musculus	95-122	
28848097-1	2017	BACKGROUND/AIMS: This study investigated signaling pathways via which extracellular histones induce the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) release from the macrophage cell line RAW 264.7 and the anti-inflammatory efficacy of the antioxidant alpha-lipoic acid (ALA).	Thioctic Acid	272-289	tumor necrosis factor	Mus musculus	159-168	
28848097-1	2017	BACKGROUND/AIMS: This study investigated signaling pathways via which extracellular histones induce the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) release from the macrophage cell line RAW 264.7 and the anti-inflammatory efficacy of the antioxidant alpha-lipoic acid (ALA).	Thioctic Acid	291-294	tumor necrosis factor	Mus musculus	159-168	
28848097-3	2017	The effects of ALA on the release of TNF-alpha and phospho-activation of the MAPKs and NF-kappaB p65 were studied.	Thioctic Acid	15-18	tumor necrosis factor	Mus musculus	37-46	
28848097-7	2017	ALA reduced histone-induced TNF-alpha release, ERK/p38 MAPK activation, and NF-kB activation without affecting macrophage viability.	Thioctic Acid	0-3	tumor necrosis factor	Mus musculus	28-37	
24721398-1	2014	OBJECTIVE: To investigate the effects of lipoic acid (LA) on the release of TNF-alpha, IL-1beta, IL-6, IL-10 and the expressions of chemokines in astrocytes stimulated with lipopolysaccharide (LPS).	Thioctic Acid	41-52	tumor necrosis factor	Mus musculus	76-85	
18158360-2	2008	We have shown previously that the dithiol compound alpha-lipoic acid (LA) exerts antiinflammatory effects by inhibiting tumor necrosis factor-alpha- and lipopolysaccharide-induced endothelial and monocyte activation in vitro and lipopolysaccharide-induced acute inflammatory responses in vivo.	Thioctic Acid	51-68	tumor necrosis factor	Mus musculus	120-147	
19563446-13	2009	Further, choline and/or alpha-lipoic acid treatment suppressed TNF-alpha level significantly as compared with that of ovalbumin-challenged mice.	Thioctic Acid	24-41	tumor necrosis factor	Mus musculus	63-72	
35490905-6	2022	RT-qPCR was used to detect the effect of ALA on gene expression of tumor necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the SN and spinal cord of MPTP-induced mice.	Thioctic Acid	41-44	tumor necrosis factor	Mus musculus	67-94	
16574204-13	2006	In parallel to the growth inhibitory effect, ALA also affects a key inflammatory signaling pathway by inhibiting TNFalpha-induced NF-kappaB signaling activity.	Thioctic Acid	45-48	tumor necrosis factor	Mus musculus	113-121	
10880392-11	2000	Conversely, the antioxidant alpha-lipoic acid, that protected against the loss of glutathione in cells exposed to TNF+Act D completely prevented mitochondrial damage, caspase activation, cytochrome C release, and apoptosis.	Thioctic Acid	28-45	tumor necrosis factor	Mus musculus	114-117	
35490905-6	2022	RT-qPCR was used to detect the effect of ALA on gene expression of tumor necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the SN and spinal cord of MPTP-induced mice.	Thioctic Acid	41-44	tumor necrosis factor	Mus musculus	96-105	
35490905-9	2022	Western blot and RT-qPCR showed that ALA significantly reduced the expression of NF-kappaB, TNF-alpha and iNOS in the nigra and spinal cord (P < 0.05).	Thioctic Acid	37-40	tumor necrosis factor	Mus musculus	92-101	
35187969-4	2022	Histopathological and biochemical analyses showed that ALA significantly reduced BLM-induced dermal thickness, inflammation score, and mRNA expression of tumor necrosis factor-alpha (TNF-alpha) in the skin.	Thioctic Acid	55-58	tumor necrosis factor	Mus musculus	154-181	
35187969-4	2022	Histopathological and biochemical analyses showed that ALA significantly reduced BLM-induced dermal thickness, inflammation score, and mRNA expression of tumor necrosis factor-alpha (TNF-alpha) in the skin.	Thioctic Acid	55-58	tumor necrosis factor	Mus musculus	183-192