PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19563446-13 2009 Further, choline and/or alpha-lipoic acid treatment suppressed TNF-alpha level significantly as compared with that of ovalbumin-challenged mice. Thioctic Acid 24-41 tumor necrosis factor Mus musculus 63-72 35490905-6 2022 RT-qPCR was used to detect the effect of ALA on gene expression of tumor necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the SN and spinal cord of MPTP-induced mice. Thioctic Acid 41-44 tumor necrosis factor Mus musculus 67-94 18158360-2 2008 We have shown previously that the dithiol compound alpha-lipoic acid (LA) exerts antiinflammatory effects by inhibiting tumor necrosis factor-alpha- and lipopolysaccharide-induced endothelial and monocyte activation in vitro and lipopolysaccharide-induced acute inflammatory responses in vivo. Thioctic Acid 51-68 tumor necrosis factor Mus musculus 120-147 16574204-13 2006 In parallel to the growth inhibitory effect, ALA also affects a key inflammatory signaling pathway by inhibiting TNFalpha-induced NF-kappaB signaling activity. Thioctic Acid 45-48 tumor necrosis factor Mus musculus 113-121 10880392-11 2000 Conversely, the antioxidant alpha-lipoic acid, that protected against the loss of glutathione in cells exposed to TNF+Act D completely prevented mitochondrial damage, caspase activation, cytochrome C release, and apoptosis. Thioctic Acid 28-45 tumor necrosis factor Mus musculus 114-117 35490905-6 2022 RT-qPCR was used to detect the effect of ALA on gene expression of tumor necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the SN and spinal cord of MPTP-induced mice. Thioctic Acid 41-44 tumor necrosis factor Mus musculus 96-105 35490905-9 2022 Western blot and RT-qPCR showed that ALA significantly reduced the expression of NF-kappaB, TNF-alpha and iNOS in the nigra and spinal cord (P < 0.05). Thioctic Acid 37-40 tumor necrosis factor Mus musculus 92-101 28848097-0 2017 Alpha-Lipoic Acid Suppresses Extracellular Histone-Induced Release of the Infammatory Mediator Tumor Necrosis Factor-alpha by Macrophages. Thioctic Acid 0-17 tumor necrosis factor Mus musculus 95-122 35187969-4 2022 Histopathological and biochemical analyses showed that ALA significantly reduced BLM-induced dermal thickness, inflammation score, and mRNA expression of tumor necrosis factor-alpha (TNF-alpha) in the skin. Thioctic Acid 55-58 tumor necrosis factor Mus musculus 154-181 35187969-4 2022 Histopathological and biochemical analyses showed that ALA significantly reduced BLM-induced dermal thickness, inflammation score, and mRNA expression of tumor necrosis factor-alpha (TNF-alpha) in the skin. Thioctic Acid 55-58 tumor necrosis factor Mus musculus 183-192 28848097-1 2017 BACKGROUND/AIMS: This study investigated signaling pathways via which extracellular histones induce the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) release from the macrophage cell line RAW 264.7 and the anti-inflammatory efficacy of the antioxidant alpha-lipoic acid (ALA). Thioctic Acid 272-289 tumor necrosis factor Mus musculus 159-168 28848097-1 2017 BACKGROUND/AIMS: This study investigated signaling pathways via which extracellular histones induce the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) release from the macrophage cell line RAW 264.7 and the anti-inflammatory efficacy of the antioxidant alpha-lipoic acid (ALA). Thioctic Acid 291-294 tumor necrosis factor Mus musculus 159-168 28848097-3 2017 The effects of ALA on the release of TNF-alpha and phospho-activation of the MAPKs and NF-kappaB p65 were studied. Thioctic Acid 15-18 tumor necrosis factor Mus musculus 37-46 28848097-7 2017 ALA reduced histone-induced TNF-alpha release, ERK/p38 MAPK activation, and NF-kB activation without affecting macrophage viability. Thioctic Acid 0-3 tumor necrosis factor Mus musculus 28-37 24721398-1 2014 OBJECTIVE: To investigate the effects of lipoic acid (LA) on the release of TNF-alpha, IL-1beta, IL-6, IL-10 and the expressions of chemokines in astrocytes stimulated with lipopolysaccharide (LPS). Thioctic Acid 41-52 tumor necrosis factor Mus musculus 76-85