PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17259747-8	2007	RESULTS: Serum ALT, AST, and LDH activities and TNF-alpha and IL-1beta levels were elevated in the I/R group, while this increase was significantly lower in the group of animals treated concomitantly with lipoic acid.	Thioctic Acid	205-216	interleukin 1 beta	Rattus norvegicus	62-70	
26518973-8	2016	Treatment with ALA significantly attenuated the levels of superoxide, gp91(phox), gp47(phox), ACE, AT1-R, IL-1beta and IL-6, increased the levels of IL-10 and Cu/Zn-SOD, and decreased MAP and RSNA compared with high-salt induced hypertensive rats.	Thioctic Acid	15-18	interleukin 1 beta	Rattus norvegicus	106-114	
24962643-5	2015	Our data indicated that ALA pretreatment reduced LPS-stimulated release of inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1 beta (IL-1beta), as well as IL-6, in HBZY-1 cell supernatant.	Thioctic Acid	24-27	interleukin 1 beta	Rattus norvegicus	148-171	
24962643-5	2015	Our data indicated that ALA pretreatment reduced LPS-stimulated release of inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1 beta (IL-1beta), as well as IL-6, in HBZY-1 cell supernatant.	Thioctic Acid	24-27	interleukin 1 beta	Rattus norvegicus	173-181	
24738479-7	2014	Furthermore, early treatment with ALA markedly inhibited the release of tumour necrosis factor-alpha, interleukin (IL)-6 and IL-1beta into the serum and reduced mRNA and protein expression of inducible nitric oxide synthase and high mobility group box 1 in kidney tissues from CLP-induced rats.	Thioctic Acid	34-37	interleukin 1 beta	Rattus norvegicus	125-133	
23911880-10	2013	ALA administration increased BMD levels and decreased osteocalcin, osteopontin, IL-1 beta, IL-6, and TNF-alpha levels versus OVX and OVX+INF control groups.	Thioctic Acid	0-3	interleukin 1 beta	Rattus norvegicus	80-89	
20584203-0	2011	Neuropharmacological effects of lipoic acid and ubiquinone on the mRNA level of interleukin-1beta and acetylcholinesterase activity in rat hippocampus after seizures.	Thioctic Acid	32-43	interleukin 1 beta	Rattus norvegicus	80-97	
20584203-1	2011	The purpose of this study was to investigate the neuroprotective effects of lipoic acid and ubiquinone on interleukin-1beta (IL-1beta) mRNA levels and acetylcholinesterase (AChE) activities in rat hippocampus after pilocarpine-induced seizures.	Thioctic Acid	76-87	interleukin 1 beta	Rattus norvegicus	106-123	
20584203-1	2011	The purpose of this study was to investigate the neuroprotective effects of lipoic acid and ubiquinone on interleukin-1beta (IL-1beta) mRNA levels and acetylcholinesterase (AChE) activities in rat hippocampus after pilocarpine-induced seizures.	Thioctic Acid	76-87	interleukin 1 beta	Rattus norvegicus	125-133	
34026086-7	2021	Moreover, 200 mg/kg BW ALA significantly decreased the hepatic levels of NLRP3 inflammasome activation-related proteins NLRP3, caspase-1, and interleukin-1beta expression by 40.0%, 60.1%, and 24.5%, respectively, in T2DM rats.	Thioctic Acid	23-26	interleukin 1 beta	Rattus norvegicus	142-159	
31333648-14	2019	ALA improved the cardiac and renal functions, downregulated the expression levels of interleukin-1beta, tumor necrosis factor-alpha, and inducible nitric oxide synthase in the myocardium and small intestine of septic rats.	Thioctic Acid	0-3	interleukin 1 beta	Rattus norvegicus	85-131	
31802922-13	2019	JMT and ALA also decreased IL-1beta, IL-18, and GSDMDC1 protein expression.	Thioctic Acid	8-11	interleukin 1 beta	Rattus norvegicus	27-35	
29996116-8	2018	Furthermore, alpha-LA induced the polarization of microglia to the M2 phenotype, modulated the expression of IL-1beta, IL-6, TNF-alpha and IL-10, and attenuated the activation of NF-kappaB after MCAO.	Thioctic Acid	13-21	interleukin 1 beta	Rattus norvegicus	109-117	
28606823-8	2017	ALA reduced BBB permeability and TNF-alpha levels in hippocampus in 24 h and IL-1beta levels and MPO activity in hippocampus and prefrontal cortex in 24 h. ALA reduced nitrite/nitrate concentration and lipid peroxidation in 24 h in all structures and protein carbonylation in 12 and 24 h in hippocampus and cortex.	Thioctic Acid	156-159	interleukin 1 beta	Rattus norvegicus	77-85