PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28992629-0	2017	alpha-Lipoic Acid Promotes Neurological Recovery After Ischemic Stroke by Activating the Nrf2/HO-1 Pathway to Attenuate Oxidative Damage.	Thioctic Acid	0-17	heme oxygenase 1	Rattus norvegicus	94-98	
29879626-0	2018	Alpha lipoic acid exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats.	Thioctic Acid	0-17	heme oxygenase 1	Rattus norvegicus	53-57	
29879626-15	2018	ALA exerted its antioxidant effect via Nrf2/HO-1 pathway as well as it showed anti-inflammatory and antiapoptotic effects by reducing TNF-alpha, iNOS, COX-2 and caspase-3 levels in liver tissue homogenate.	Thioctic Acid	0-3	heme oxygenase 1	Rattus norvegicus	44-48	
29879626-17	2018	It was concluded that ALA has hepatoprotective effects against MTX-induced hepatic injury mediated by Nrf2/HO-1 pathway as well as anti-inflammatory and antiapoptotic properties.	Thioctic Acid	22-25	heme oxygenase 1	Rattus norvegicus	107-111	
28992629-14	2017	CONCLUSION: alpha-LA treatment is neuroprotective and promotes functional recovery after ischemic stroke by attenuating oxidative damage, which is partially mediated by the Nrf2/HO-1 pathway.	Thioctic Acid	12-20	heme oxygenase 1	Rattus norvegicus	178-182	
28992629-13	2017	Conversely, knockdown of Nrf2 or HO-1 resulted in the down-regulation of HO-1 protein and inhibited the neuroprotective effect of alpha-LA.	Thioctic Acid	130-138	heme oxygenase 1	Rattus norvegicus	33-37	
22863080-8	2012	Expression of the antioxidant enzymes heme oxygenase-1 and Cu/Zn-superoxide dismutase was increased in the livers of ALA-treated rats.	Thioctic Acid	117-120	heme oxygenase 1	Rattus norvegicus	38-54	
26250907-7	2015	Conversely, pre-treatment of the hydrogen peroxide-exposed cells to melatonin or alpha-lipoic acid increased endogenous antioxidant enzymes, including superoxide dismutase-2 and heme oxygenase-1; moreover, they ameliorated significantly oxidative stress damage and partially reduced alterations in the muscle cells, which are typical of aging.	Thioctic Acid	81-98	heme oxygenase 1	Rattus norvegicus	178-194	
26187709-0	2015	Lipoic acid and pentoxifylline mitigate nandrolone decanoate-induced neurobehavioral perturbations in rats via re-balance of brain neurotransmitters, up-regulation of Nrf2/HO-1 pathway, and down-regulation of TNFR1 expression.	Thioctic Acid	0-11	heme oxygenase 1	Rattus norvegicus	172-176	
26187709-13	2015	Lipoic acid and pentoxifylline combination significantly mitigated all the previously mentioned deleterious effects mainly via up-regulation of Nrf2/HO-1 pathway, inhibition of TNF-alpha and down-regulation of TNFR1 expression.	Thioctic Acid	0-11	heme oxygenase 1	Rattus norvegicus	149-153	
16631521-3	2006	The aim of this study was to investigate whether the antioxidant effect of ALA is mediated by the induction of heme oxygenase (HO)-1 in rat aortic smooth muscle cells (A10 cells).	Thioctic Acid	75-78	heme oxygenase 1	Rattus norvegicus	111-132	
18789599-5	2009	Thus, it is intriguing to speculate that the remarkable antioxidant effects of lipoic acid therapy reflect not only induction of phase 2 antioxidants (e.g. glutathione and heme oxygenase-1), but also induction of various proteins that function expressly to protect mitochondria from self-generated oxidant stress.	Thioctic Acid	79-90	heme oxygenase 1	Rattus norvegicus	172-188