PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16123320-0	2005	Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells.	Thioctic Acid	0-17	mitogen-activated protein kinase 14	Homo sapiens	117-120	
16123320-10	2005	Pretreatment with SB203580, a p38 mitogen-activated protein kinase inhibitor, reduced ALA-induced HO-1 mRNA expression by 75% and inhibited ALA-induced Nrf2 binding to the HO-1 ARE.	Thioctic Acid	86-89	mitogen-activated protein kinase 14	Homo sapiens	30-33	
16123320-10	2005	Pretreatment with SB203580, a p38 mitogen-activated protein kinase inhibitor, reduced ALA-induced HO-1 mRNA expression by 75% and inhibited ALA-induced Nrf2 binding to the HO-1 ARE.	Thioctic Acid	140-143	mitogen-activated protein kinase 14	Homo sapiens	30-33	
16123320-11	2005	CONCLUSIONS: These results demonstrate that ALA induces HO-1 expression in THP-1 monocytic cells via Nrf2 and p38.	Thioctic Acid	44-47	mitogen-activated protein kinase 14	Homo sapiens	110-113	
22713251-19	2012	CONCLUSIONS: These results, coupled with the excellent safety and tolerability profile of ALA in humans, demonstrate that ALA may have therapeutic potential in the treatment of DCM by attenuating MOS, ECM remodeling and JNK, p38 MAPK activation.	Thioctic Acid	122-125	mitogen-activated protein kinase 14	Homo sapiens	225-228	
11375349-0	2001	The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.	Thioctic Acid	27-44	mitogen-activated protein kinase 14	Homo sapiens	140-176	
33321563-8	2021	In addition, ALA significantly enhanced radiation-induced cellular senescence, which was shown by increased HMGB1 expression in the cytosol fraction compared to the control, increased p53 expression compared to the control, activation of p38 as well as NF-kappaB, and G2/M cell cycle arrest.	Thioctic Acid	13-16	mitogen-activated protein kinase 14	Homo sapiens	238-241	
24796665-4	2014	ALA pretreatment significantly reduced apoptotic cell death of the inner and outer hair cells in cisplatin-treated organ of Corti explants and attenuated ototoxicity via marked inhibition of the increase in the expression of IL-1beta and IL-6, the phosphorylation of ERK and p38, the degradation of IkappaBalpha, the increase in intracellular levels of ROS, and the activation of caspase-3 in cisplatin-treated HEI-OC1 cells.	Thioctic Acid	0-3	mitogen-activated protein kinase 14	Homo sapiens	275-278	
20829507-0	2010	alpha-Lipoic acid prevents neointimal hyperplasia via induction of p38 mitogen-activated protein kinase/Nur77-mediated apoptosis of vascular smooth muscle cells and accelerates postinjury reendothelialization.	Thioctic Acid	0-17	mitogen-activated protein kinase 14	Homo sapiens	67-70	
20829507-5	2010	Moreover, ALA increased p38 mitogen-activated protein kinase phosphorylation, and inhibition of p38 mitogen-activated protein kinase completely blocked ALA-induced vascular smooth muscle cell apoptosis and Nur77 induction and cytoplasmic localization.	Thioctic Acid	10-13	mitogen-activated protein kinase 14	Homo sapiens	24-27	
20829507-5	2010	Moreover, ALA increased p38 mitogen-activated protein kinase phosphorylation, and inhibition of p38 mitogen-activated protein kinase completely blocked ALA-induced vascular smooth muscle cell apoptosis and Nur77 induction and cytoplasmic localization.	Thioctic Acid	152-155	mitogen-activated protein kinase 14	Homo sapiens	96-99