PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34305580-5 2021 The altered levels of blood delta-aminolevulinic acid dehydratase (ALAD), immunoglobulins (IgA, IgG, IgM, and IgE), interleukins (IL-1beta, IL-4, and IL-6), caspase-3, and tumor necrosis factor (TNF-alpha) were attenuated by lipoic acid treatment. Thioctic Acid 225-236 tumor necrosis factor Rattus norvegicus 195-204 16413026-7 2006 Additionally, ALA inhibited TNF-alpha-stimulated fractalkine expression in cultured vascular smooth muscle cells (VSMCs), a process which is mediated through the NF-kappaB pathway. Thioctic Acid 14-17 tumor necrosis factor Rattus norvegicus 28-37 16413026-8 2006 In addition to fractalkine, ALA successfully inhibited TNF-alpha-stimulated expression of vascular cell adhesion molecule-1 and monocyte chemotactic protein-1 in cultured VSMCs. Thioctic Acid 28-31 tumor necrosis factor Rattus norvegicus 55-64 12406389-0 2002 Inhibition of LPS-induced nitric oxide and TNF-alpha production by alpha-lipoic acid in rat Kupffer cells and in RAW 264.7 murine macrophages. Thioctic Acid 67-84 tumor necrosis factor Rattus norvegicus 43-52 12406389-2 2002 The aim of this study was to investigate the effect of the hepatoprotective compound alpha-lipoic acid (thioctic acid) on the production of nitric oxide and TNF-alpha in isolated rat Kupffer cells and RAW 264.7 macrophages. Thioctic Acid 85-102 tumor necrosis factor Rattus norvegicus 157-166 12406389-2 2002 The aim of this study was to investigate the effect of the hepatoprotective compound alpha-lipoic acid (thioctic acid) on the production of nitric oxide and TNF-alpha in isolated rat Kupffer cells and RAW 264.7 macrophages. Thioctic Acid 104-117 tumor necrosis factor Rattus norvegicus 157-166 12406389-9 2002 alpha-Lipoic acid did not alter basal TNF-alpha secretion in Kupffer cells, whereas it significantly inhibited lipopolysaccharide-induced TNF-alpha production. Thioctic Acid 0-17 tumor necrosis factor Rattus norvegicus 138-147 12406389-10 2002 alpha-Lipoic acid attenuated the activation of nuclear factor-kappaB and AP-1, two transcription factors pivotal in induction of inducible nitric oxide synthase and TNF-alpha. Thioctic Acid 0-17 tumor necrosis factor Rattus norvegicus 165-174 12406389-11 2002 alpha-Lipoic acid significantly inhibits lipopolysaccharide-induced macrophage production of nitric oxide and TNF-alpha via an attenuated activation of NF-kappaB and activator protein-1. Thioctic Acid 0-17 tumor necrosis factor Rattus norvegicus 110-119 12406389-12 2002 The reduced production of nitric oxide and TNF-alpha in Kupffer cells may be involved in the hepatoprotective action conveyed by alpha-lipoic acid. Thioctic Acid 129-146 tumor necrosis factor Rattus norvegicus 43-52 19823117-7 2010 alpha-Lipoic acid decreased the serum levels of inflammatory cytokines such as TNF-alpha and IL-6, which increased after CLP. Thioctic Acid 0-17 tumor necrosis factor Rattus norvegicus 79-88 19823117-10 2010 We can suggest that ALA showed beneficial effects by decreasing nuclear factor kappaB activation in lung tissues, resulting in decreased serum levels of TNF-alpha and IL-6, and also increasing the antioxidant capacity of the lungs. Thioctic Acid 20-23 tumor necrosis factor Rattus norvegicus 153-162 17274632-7 2007 RESULTS: Alpha-lipoic acid decreased actinomycinD/TNF-alpha-induced apoptosis, as did the antioxidants Trolox and N-acetylcysteine. Thioctic Acid 9-26 tumor necrosis factor Rattus norvegicus 50-59 17274632-9 2007 Alpha-lipoic acid but not other antioxidants protected against actinomycinD/TNF-alpha-induced apoptosis via phosphorylation of the insulin receptor. Thioctic Acid 0-17 tumor necrosis factor Rattus norvegicus 76-85 17259747-8 2007 RESULTS: Serum ALT, AST, and LDH activities and TNF-alpha and IL-1beta levels were elevated in the I/R group, while this increase was significantly lower in the group of animals treated concomitantly with lipoic acid. Thioctic Acid 205-216 tumor necrosis factor Rattus norvegicus 48-57 33775218-11 2021 BM-MNCs combination with NAC or ALA exerted significant antioxidant, anti-inflammatory and anti-cytogenetical aberrations effect compared to each of them alone.HighlightsCCl4 elevated ALT, AST, TNF-alpha, IL-6 and MDACCl4 reduced ALB, IL-10, SOD, CAT, GPx and TACCCl4 increased the number of DNA breaks in liverNAC, ALA and BM-MNCs reduced ALT, AST, while, increase albumin, CAT, TAC, GPx, SODNAC, ALA and BM-MNCs decreased in MDA, IL-6 and TNF-alpha and increased IL-10. Thioctic Acid 32-35 tumor necrosis factor Rattus norvegicus 194-203 33775218-11 2021 BM-MNCs combination with NAC or ALA exerted significant antioxidant, anti-inflammatory and anti-cytogenetical aberrations effect compared to each of them alone.HighlightsCCl4 elevated ALT, AST, TNF-alpha, IL-6 and MDACCl4 reduced ALB, IL-10, SOD, CAT, GPx and TACCCl4 increased the number of DNA breaks in liverNAC, ALA and BM-MNCs reduced ALT, AST, while, increase albumin, CAT, TAC, GPx, SODNAC, ALA and BM-MNCs decreased in MDA, IL-6 and TNF-alpha and increased IL-10. Thioctic Acid 32-35 tumor necrosis factor Rattus norvegicus 441-450 35354137-8 2022 Moreover, ALA and/or MET prevented the increase in MDA and TNF-alpha, and the decline in GSH, NO, BDNF, 5-HT, NE and DA. Thioctic Acid 10-13 tumor necrosis factor Rattus norvegicus 59-68 34084105-15 2021 However, TNF-alpha expression was high in some preparations in the ALA-treated group. Thioctic Acid 67-70 tumor necrosis factor Rattus norvegicus 9-18 29486337-7 2018 The results revealed that ALA pretreatment significantly decreased the ulcer index, the gastric levels of MDA, TNF-alpha, PAI-1, and iNOS protein expression while increased the gastric levels of TAC as well as improved the histopathological appearance of gastric tissues. Thioctic Acid 26-29 tumor necrosis factor Rattus norvegicus 111-120 32921159-7 2021 ALA suppressed the mRNA expression of Nox4, p22phox, TNF-alpha and KIM-1. Thioctic Acid 0-3 tumor necrosis factor Rattus norvegicus 53-62 31025242-11 2020 ALA also significantly reduced mRNA expressions of NOX4 and p22phox induced by IS, which was parallel to significant decreases of TNF-alpha and KIM-1 mRNA expressions. Thioctic Acid 0-3 tumor necrosis factor Rattus norvegicus 130-139 31885498-8 2019 Proinflammatory cytokine TNF-alpha and NF-kappaB pathways were significantly reduced by ALA treatment which may be associated with the upregulation of Hsp70. Thioctic Acid 88-91 tumor necrosis factor Rattus norvegicus 25-34 35391928-10 2022 In addition, we demonstrated that ALA decreases levels of proinflammatory TNF-alpha but also increases the synthesis of anti-inflammatory IL-10 in the hypothalamus of insulin-resistant rats. Thioctic Acid 34-37 tumor necrosis factor Rattus norvegicus 74-83 30362597-6 2019 Administration of ALA and AL-1 significantly reduced the tumor necrosis factor-alpha level compared with the controls, while data were not noteworthy in the meta-analysis (mean differences = -18.57 [95% CI = -42.65 to 5.51], P = 0.13). Thioctic Acid 18-21 tumor necrosis factor Rattus norvegicus 57-84 29879626-15 2018 ALA exerted its antioxidant effect via Nrf2/HO-1 pathway as well as it showed anti-inflammatory and antiapoptotic effects by reducing TNF-alpha, iNOS, COX-2 and caspase-3 levels in liver tissue homogenate. Thioctic Acid 0-3 tumor necrosis factor Rattus norvegicus 134-143 28429826-10 2017 In the ALA group, the serum TOS and OSI levels, the endometrial implant volumes, the TNF-alpha levels in serum and peritoneal fluid, and the histopathologic scores were significantly lower compared to the control group (P < 0.05). Thioctic Acid 7-10 tumor necrosis factor Rattus norvegicus 85-94 29996116-8 2018 Furthermore, alpha-LA induced the polarization of microglia to the M2 phenotype, modulated the expression of IL-1beta, IL-6, TNF-alpha and IL-10, and attenuated the activation of NF-kappaB after MCAO. Thioctic Acid 13-21 tumor necrosis factor Rattus norvegicus 125-134 25912852-7 2015 On the other hand, the immune staining of iNOS and TNF-alpha were observed most densely in the MTX group, while the density decreased in the PTX- and ALA-administered groups. Thioctic Acid 150-153 tumor necrosis factor Rattus norvegicus 51-60 27055478-10 2016 Moreover, ALA obviously inhibited TNF-alpha secretion and Wnt/beta-catenin signaling way. Thioctic Acid 10-13 tumor necrosis factor Rattus norvegicus 34-43 28606823-8 2017 ALA reduced BBB permeability and TNF-alpha levels in hippocampus in 24 h and IL-1beta levels and MPO activity in hippocampus and prefrontal cortex in 24 h. ALA reduced nitrite/nitrate concentration and lipid peroxidation in 24 h in all structures and protein carbonylation in 12 and 24 h in hippocampus and cortex. Thioctic Acid 0-3 tumor necrosis factor Rattus norvegicus 33-42 28606823-8 2017 ALA reduced BBB permeability and TNF-alpha levels in hippocampus in 24 h and IL-1beta levels and MPO activity in hippocampus and prefrontal cortex in 24 h. ALA reduced nitrite/nitrate concentration and lipid peroxidation in 24 h in all structures and protein carbonylation in 12 and 24 h in hippocampus and cortex. Thioctic Acid 156-159 tumor necrosis factor Rattus norvegicus 33-42 25825413-10 2016 Immunohistochemical expressions of tumor necrosis factor alpha and inducible nitric oxide synthase were increased in HFCS group, and these receptor levels were decreased by alpha-LA treatment. Thioctic Acid 173-181 tumor necrosis factor Rattus norvegicus 35-62 26187709-13 2015 Lipoic acid and pentoxifylline combination significantly mitigated all the previously mentioned deleterious effects mainly via up-regulation of Nrf2/HO-1 pathway, inhibition of TNF-alpha and down-regulation of TNFR1 expression. Thioctic Acid 0-11 tumor necrosis factor Rattus norvegicus 177-186 23911880-10 2013 ALA administration increased BMD levels and decreased osteocalcin, osteopontin, IL-1 beta, IL-6, and TNF-alpha levels versus OVX and OVX+INF control groups. Thioctic Acid 0-3 tumor necrosis factor Rattus norvegicus 101-110 25266599-1 2015 BACKGROUND: Recent evidence indicates that alpha-lipoic acid (alpha-LA) has a variety of liver-protective effects through the suppression of inflammatory mediators including tumor necrosis factor (TNF)-alpha and inducible nitric oxide synthase (iNOS). Thioctic Acid 43-60 tumor necrosis factor Rattus norvegicus 174-207 25266599-1 2015 BACKGROUND: Recent evidence indicates that alpha-lipoic acid (alpha-LA) has a variety of liver-protective effects through the suppression of inflammatory mediators including tumor necrosis factor (TNF)-alpha and inducible nitric oxide synthase (iNOS). Thioctic Acid 62-70 tumor necrosis factor Rattus norvegicus 174-207 24962643-5 2015 Our data indicated that ALA pretreatment reduced LPS-stimulated release of inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1 beta (IL-1beta), as well as IL-6, in HBZY-1 cell supernatant. Thioctic Acid 24-27 tumor necrosis factor Rattus norvegicus 107-134 24962643-5 2015 Our data indicated that ALA pretreatment reduced LPS-stimulated release of inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1 beta (IL-1beta), as well as IL-6, in HBZY-1 cell supernatant. Thioctic Acid 24-27 tumor necrosis factor Rattus norvegicus 136-145 25095635-0 2014 [Influence of lipoic acid on the level of TNF-alpha in spleen homogenates]. Thioctic Acid 14-25 tumor necrosis factor Rattus norvegicus 42-51 24008266-8 2013 Conversely, the levels of interleukin 6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) were decreased following treatment with alpha-LA. Thioctic Acid 132-140 tumor necrosis factor Rattus norvegicus 81-90 23403734-5 2013 Serum MDA and TNF-alpha levels were both decreased in the ALA and silymarin groups. Thioctic Acid 58-61 tumor necrosis factor Rattus norvegicus 14-23