PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31366086-0	2019	Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation.	Thioctic Acid	0-11	tumor protein p53	Homo sapiens	83-86	
32345994-5	2020	Previously, we demonstrated that the treatment of hepatoma cells with alpha-LA induced apoptosis, which was preceded by the generation of reactive oxygen species (ROS) and activation of the p53 protein, a known inducer of mitochondria-mediated apoptosis.	Thioctic Acid	70-78	tumor protein p53	Homo sapiens	190-193	
33321563-8	2021	In addition, ALA significantly enhanced radiation-induced cellular senescence, which was shown by increased HMGB1 expression in the cytosol fraction compared to the control, increased p53 expression compared to the control, activation of p38 as well as NF-kappaB, and G2/M cell cycle arrest.	Thioctic Acid	13-16	tumor protein p53	Homo sapiens	184-187	
26312825-0	2015	AMPK/p53 Axis Is Essential for alpha-Lipoic Acid-Regulated Metastasis in Human and Mouse Colon Cancer Cells.	Thioctic Acid	31-48	tumor protein p53	Homo sapiens	5-8	
25526924-0	2015	Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil.	Thioctic Acid	0-11	tumor protein p53	Homo sapiens	20-23	
26312825-8	2015	Finally, we observed that ALA activates p53 and AMPK signaling pathways in human and mouse colon cancer cells.	Thioctic Acid	26-29	tumor protein p53	Homo sapiens	40-43	
26312825-9	2015	We found for the first time that ALA suppresses cell proliferation and malignant potential via p53 and AMPK signaling pathways in human and mouse colon cancer cells.	Thioctic Acid	33-36	tumor protein p53	Homo sapiens	95-98	
23599020-0	2013	alpha-Lipoic acid prevents p53 degradation in colon cancer cells by blocking NF-kappaB induction of RPS6KA4.	Thioctic Acid	0-17	tumor protein p53	Homo sapiens	27-30	
17136495-0	2007	Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells.	Thioctic Acid	47-64	tumor protein p53	Homo sapiens	29-32