PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28772267-0	2017	Alpha-Lipoic Acid Alleviates High-Glucose Suppressed Osteogenic Differentiation of MC3T3-E1 Cells via Antioxidant Effect and PI3K/Akt Signaling Pathway.	Thioctic Acid	0-17	thymoma viral proto-oncogene 1	Mus musculus	130-133	
27796798-10	2017	In addition, our result suggests that PI3K/Akt and CREB pathways are related to the protective effect of alpha-LA.	Thioctic Acid	105-113	thymoma viral proto-oncogene 1	Mus musculus	43-46	
28772267-12	2017	Moreover, the PI3K/Akt pathway was activated by ALA.	Thioctic Acid	48-51	thymoma viral proto-oncogene 1	Mus musculus	19-22	
28772267-13	2017	CONCLUSIONS: We demonstrate that ALA may attenuate high-glucose mediated MC3T3-E1 cells dysfunction through antioxidant effect and modulation of PI3K/Akt pathway.	Thioctic Acid	33-36	thymoma viral proto-oncogene 1	Mus musculus	150-153	
19879292-0	2010	Alpha-lipoic acid prevents bupivacaine-induced neuron injury in vitro through a PI3K/Akt-dependent mechanism.	Thioctic Acid	0-17	thymoma viral proto-oncogene 1	Mus musculus	85-88	
26855124-4	2016	ALA (25 muM) significantly increased the protein synthesis and phosphorylation of Akt, mTOR, and S6 in C2C12 myotubes with attenuated phosphorylation of AMPK, Ikkalpha/beta, and eIF2alpha.	Thioctic Acid	0-3	thymoma viral proto-oncogene 1	Mus musculus	82-85	
26855124-11	2016	These findings indicate that ALA induces protein synthesis and the PI3K/Akt signaling pathway by TLR2.	Thioctic Acid	29-32	thymoma viral proto-oncogene 1	Mus musculus	72-75	
25336920-0	2014	(R)-(+)-alpha-lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3beta pathway and suppression of NF-kappabeta-cytokines.	Thioctic Acid	0-25	thymoma viral proto-oncogene 1	Mus musculus	96-99	
25336920-6	2014	Moreover, pretreatment with R-LA stimulated the activation of PI3K-Akt through mTORC1 and mTORC2 components (mTOR, rictor and raptor) and production of antiinflammatory cytokine, IL-10 which led to the inactivation of glycogen synthase kinase-3beta (GSK-3beta) and reduction of both Bax/Bcl2 and Bax/Bcl-xL ratios, accompanied by inhibition of the cleaved caspase-3.	Thioctic Acid	28-32	thymoma viral proto-oncogene 1	Mus musculus	67-70	
23562296-0	2013	alpha-Lipoic acid attenuates LPS-induced cardiac dysfunction through a PI3K/Akt-dependent mechanism.	Thioctic Acid	0-17	thymoma viral proto-oncogene 1	Mus musculus	76-79	
23562296-3	2013	We have reported previously that alpha-lipoic acid (LA) activates PI3K/Akt pathway in neuronal cells.	Thioctic Acid	33-50	thymoma viral proto-oncogene 1	Mus musculus	71-74	
22982730-0	2012	Alpha-lipoic acid pre- and post-treatments provide protection against in vitro ischemia-reperfusion injury in cerebral endothelial cells via Akt/mTOR signaling.	Thioctic Acid	0-17	thymoma viral proto-oncogene 1	Mus musculus	141-144	
22982730-2	2012	In this study, we sought to determine whether ALA could induce pre- or post-treatment protective effects against simulated ischemia and reperfusion-induced cerebral endothelial cell (CEC) injury by activating the Akt/mTOR pathway.	Thioctic Acid	46-49	thymoma viral proto-oncogene 1	Mus musculus	213-216	
22982730-7	2012	Western blotting showed that the ALA pre- and post-treatments up-regulated the phosphorylation of Akt, mTOR, S6K and 4E-BP1 in both bEnd.3 cells and primary cultures.	Thioctic Acid	33-36	thymoma viral proto-oncogene 1	Mus musculus	98-101	
22982730-8	2012	However, after pre-treatment with rapamycin, the level of Akt phosphorylation was decreased in primary cultures of CECs but could still be restored by ALA, whereas the levels of mTOR, S6K and 4E-BP1 phosphorylation were significantly decreased and could not be restored.	Thioctic Acid	151-154	thymoma viral proto-oncogene 1	Mus musculus	58-61	
22982730-9	2012	These results suggest that ALA pre- and post-treatments provide protective effects against simulated ischemia and reperfusion-induced CEC injury by promoting the Akt/mTOR pathway and that mTOR is required for ALA protection.	Thioctic Acid	27-30	thymoma viral proto-oncogene 1	Mus musculus	162-165