PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27755990-3 2017 METHODS: We therefore investigated the effects of ALA on the expression of transferrin receptor 1 (TfR1), divalent metal transporter 1 (DMT1), ferroportin 1 (Fpn1) and ferritin in BV-2 microglia cells. Thioctic Acid 50-53 transferrin receptor Mus musculus 75-97 27755990-6 2017 We also demonstrated that ALA enhanced DMT1 and TfR1 expression in ferric ammonium citrate (FAC)-treated cells. Thioctic Acid 26-29 transferrin receptor Mus musculus 48-52 27755990-8 2017 CONCLUSIONS: ALA could up-regulate TfR1, DMT1 and ferritin expression when iron is increased outside of the cell, promoting iron deposition into ferritin by increasing cell iron uptake, and then reducing free iron both inside and outside of the cell. Thioctic Acid 13-16 transferrin receptor Mus musculus 35-39 27755990-3 2017 METHODS: We therefore investigated the effects of ALA on the expression of transferrin receptor 1 (TfR1), divalent metal transporter 1 (DMT1), ferroportin 1 (Fpn1) and ferritin in BV-2 microglia cells. Thioctic Acid 50-53 transferrin receptor Mus musculus 99-103 27755990-4 2017 RESULTS: We demonstrated that ALA significantly inhibited DMT1 expression, lowered ferritin-light-chain (Ft-L) and ferritin-heavy-chain (Ft-H) content, and had no effect on TfR1 and Fpn1 in BV-2 microglia cells. Thioctic Acid 30-33 transferrin receptor Mus musculus 173-177