PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24905530-8	2014	This may suggest that the positive effects caused by alpha lipoic acid in the cardiovascular system are not only related to its strong antioxidant activity, and the influence on the activity of such enzymes as aldehyde dehydrogenase 2, as previously suggested, but this compound can affect K(ATP) channels.	Thioctic Acid	59-70	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	210-234	
22266491-0	2012	Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation.	Thioctic Acid	0-17	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	110-134	
22266491-1	2012	Recent studies demonstrate that alpha lipoic acid can prevent nitroglycerin tolerance by restoring aldehyde dehydrogenase 2 (ALDH2) activity and ALDH2-mediated detoxification of aldehydes is thought as an endogenous mechanism against ischemia-reperfusion injury.	Thioctic Acid	32-49	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	99-123	
22266491-1	2012	Recent studies demonstrate that alpha lipoic acid can prevent nitroglycerin tolerance by restoring aldehyde dehydrogenase 2 (ALDH2) activity and ALDH2-mediated detoxification of aldehydes is thought as an endogenous mechanism against ischemia-reperfusion injury.	Thioctic Acid	32-49	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	125-130	
22266491-2	2012	This study was performed to explore whether the cardioprotective effect of alpha lipoic acid was related to activation of ALDH2 and the underlying mechanisms.	Thioctic Acid	81-92	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	122-127	
22266491-6	2012	Pretreatment with lipoic acid significantly up-regulated myocardial ALDH2 activity concomitantly with an improvement of cardiac dysfunction and a decrease in 4-HNE and MDA contents, these effects were blocked by the inhibitor of ALDH2.	Thioctic Acid	18-29	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	68-73	
22266491-6	2012	Pretreatment with lipoic acid significantly up-regulated myocardial ALDH2 activity concomitantly with an improvement of cardiac dysfunction and a decrease in 4-HNE and MDA contents, these effects were blocked by the inhibitor of ALDH2.	Thioctic Acid	18-29	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	229-234	
22266491-8	2012	Administration of lipoic acid significantly up-regulated cellular ALDH2 activity concomitantly with a reduction in apoptosis, production of reactive oxygen species, 4-HNE and MDA, these effects were reversed in the presence of ALDH2 or PKCepsilon inhibitors.	Thioctic Acid	18-29	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	66-71	
22266491-8	2012	Administration of lipoic acid significantly up-regulated cellular ALDH2 activity concomitantly with a reduction in apoptosis, production of reactive oxygen species, 4-HNE and MDA, these effects were reversed in the presence of ALDH2 or PKCepsilon inhibitors.	Thioctic Acid	18-29	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	227-232	
22266491-9	2012	Our results suggest that the cardioprotective effects of lipoic acid on ischemia-reperfusion injury are through a mechanism involving ALDH2 activation.	Thioctic Acid	57-68	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	134-139	
22266491-10	2012	The regulatory effect of lipoic acid on ALDH2 activity is dependent on PKCepsilon signaling pathway.	Thioctic Acid	25-36	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	40-45	
27814791-0	2016	Lipoic acid protects gastric mucosa from ethanol-induced injury in rat through a mechanism involving aldehyde dehydrogenase 2 activation.	Thioctic Acid	0-11	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	101-125	
27814791-2	2016	This study aims to explore whether lipoic acid, a potential ALDH2 activator, is able to protect gastric mucosa from ethanol-induced injury through a mechanism involving clearance of reactive aldehydes.	Thioctic Acid	35-46	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	60-65	
27814791-6	2016	The results showed that acute administration of ethanol led to an increase in gastric ulcer index, cellular apoptosis, 4-HNE and MDA contents concomitant with a decrease in ALDH2 activity; these phenomena were reversed by lipoic acid or Alda-1.	Thioctic Acid	222-233	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	173-178	
27814791-7	2016	The gastric protection of lipoic acid was attenuated in the presence of ALDH2 inhibitor.	Thioctic Acid	26-37	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	72-77	
27814791-8	2016	Based on these observations, we conclude that lipoic acid exerts the beneficial effects on ethanol-induced injury through a mechanism involving, at least in part, ALDH2 activation.	Thioctic Acid	46-57	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	163-168