PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27814791-0 2016 Lipoic acid protects gastric mucosa from ethanol-induced injury in rat through a mechanism involving aldehyde dehydrogenase 2 activation. Thioctic Acid 0-11 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 101-125 27814791-2 2016 This study aims to explore whether lipoic acid, a potential ALDH2 activator, is able to protect gastric mucosa from ethanol-induced injury through a mechanism involving clearance of reactive aldehydes. Thioctic Acid 35-46 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 60-65 27814791-6 2016 The results showed that acute administration of ethanol led to an increase in gastric ulcer index, cellular apoptosis, 4-HNE and MDA contents concomitant with a decrease in ALDH2 activity; these phenomena were reversed by lipoic acid or Alda-1. Thioctic Acid 222-233 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 173-178 27814791-7 2016 The gastric protection of lipoic acid was attenuated in the presence of ALDH2 inhibitor. Thioctic Acid 26-37 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 72-77 27814791-8 2016 Based on these observations, we conclude that lipoic acid exerts the beneficial effects on ethanol-induced injury through a mechanism involving, at least in part, ALDH2 activation. Thioctic Acid 46-57 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 163-168 24905530-8 2014 This may suggest that the positive effects caused by alpha lipoic acid in the cardiovascular system are not only related to its strong antioxidant activity, and the influence on the activity of such enzymes as aldehyde dehydrogenase 2, as previously suggested, but this compound can affect K(ATP) channels. Thioctic Acid 59-70 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 210-234 22266491-0 2012 Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation. Thioctic Acid 0-17 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 110-134 22266491-1 2012 Recent studies demonstrate that alpha lipoic acid can prevent nitroglycerin tolerance by restoring aldehyde dehydrogenase 2 (ALDH2) activity and ALDH2-mediated detoxification of aldehydes is thought as an endogenous mechanism against ischemia-reperfusion injury. Thioctic Acid 32-49 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 99-123 22266491-1 2012 Recent studies demonstrate that alpha lipoic acid can prevent nitroglycerin tolerance by restoring aldehyde dehydrogenase 2 (ALDH2) activity and ALDH2-mediated detoxification of aldehydes is thought as an endogenous mechanism against ischemia-reperfusion injury. Thioctic Acid 32-49 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 125-130 22266491-2 2012 This study was performed to explore whether the cardioprotective effect of alpha lipoic acid was related to activation of ALDH2 and the underlying mechanisms. Thioctic Acid 81-92 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 122-127 22266491-6 2012 Pretreatment with lipoic acid significantly up-regulated myocardial ALDH2 activity concomitantly with an improvement of cardiac dysfunction and a decrease in 4-HNE and MDA contents, these effects were blocked by the inhibitor of ALDH2. Thioctic Acid 18-29 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 68-73 22266491-6 2012 Pretreatment with lipoic acid significantly up-regulated myocardial ALDH2 activity concomitantly with an improvement of cardiac dysfunction and a decrease in 4-HNE and MDA contents, these effects were blocked by the inhibitor of ALDH2. Thioctic Acid 18-29 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 229-234 22266491-8 2012 Administration of lipoic acid significantly up-regulated cellular ALDH2 activity concomitantly with a reduction in apoptosis, production of reactive oxygen species, 4-HNE and MDA, these effects were reversed in the presence of ALDH2 or PKCepsilon inhibitors. Thioctic Acid 18-29 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 66-71 22266491-8 2012 Administration of lipoic acid significantly up-regulated cellular ALDH2 activity concomitantly with a reduction in apoptosis, production of reactive oxygen species, 4-HNE and MDA, these effects were reversed in the presence of ALDH2 or PKCepsilon inhibitors. Thioctic Acid 18-29 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 227-232 22266491-9 2012 Our results suggest that the cardioprotective effects of lipoic acid on ischemia-reperfusion injury are through a mechanism involving ALDH2 activation. Thioctic Acid 57-68 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 134-139 22266491-10 2012 The regulatory effect of lipoic acid on ALDH2 activity is dependent on PKCepsilon signaling pathway. Thioctic Acid 25-36 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 40-45