PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29879626-15	2018	ALA exerted its antioxidant effect via Nrf2/HO-1 pathway as well as it showed anti-inflammatory and antiapoptotic effects by reducing TNF-alpha, iNOS, COX-2 and caspase-3 levels in liver tissue homogenate.	Thioctic Acid	0-3	nitric oxide synthase 2	Rattus norvegicus	145-149	
23489699-6	2013	Similarly, eyes sections from rats pre-treated with ALA and SOD showed reduced differential expression of inducible nitric oxide synthase (iNOS) and of caspase-3 in compared to normally-fed/MTC-inoculated cases.	Thioctic Acid	52-55	nitric oxide synthase 2	Rattus norvegicus	106-137	
29486337-7	2018	The results revealed that ALA pretreatment significantly decreased the ulcer index, the gastric levels of MDA, TNF-alpha, PAI-1, and iNOS protein expression while increased the gastric levels of TAC as well as improved the histopathological appearance of gastric tissues.	Thioctic Acid	26-29	nitric oxide synthase 2	Rattus norvegicus	133-137	
25912852-7	2015	On the other hand, the immune staining of iNOS and TNF-alpha were observed most densely in the MTX group, while the density decreased in the PTX- and ALA-administered groups.	Thioctic Acid	150-153	nitric oxide synthase 2	Rattus norvegicus	42-46	
24962643-6	2015	Moreover, LPS-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) was inhibited by ALA pretreatment, and consequently, the secretion levels of their respective enzymatic products prostaglandin E2 (PGE2) and nitric oxide (NO) were significantly decreased.	Thioctic Acid	121-124	nitric oxide synthase 2	Rattus norvegicus	65-96	
24962643-6	2015	Moreover, LPS-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) was inhibited by ALA pretreatment, and consequently, the secretion levels of their respective enzymatic products prostaglandin E2 (PGE2) and nitric oxide (NO) were significantly decreased.	Thioctic Acid	121-124	nitric oxide synthase 2	Rattus norvegicus	98-102	
24962643-8	2015	Additionally, the NF-kappaB inhibitor N-acetylcysteine (NAC) exerted similar inhibitory effects as ALA on COX-2 and iNOS expression.	Thioctic Acid	99-102	nitric oxide synthase 2	Rattus norvegicus	116-120	
25266599-1	2015	BACKGROUND: Recent evidence indicates that alpha-lipoic acid (alpha-LA) has a variety of liver-protective effects through the suppression of inflammatory mediators including tumor necrosis factor (TNF)-alpha and inducible nitric oxide synthase (iNOS).	Thioctic Acid	43-60	nitric oxide synthase 2	Rattus norvegicus	212-243	
25266599-1	2015	BACKGROUND: Recent evidence indicates that alpha-lipoic acid (alpha-LA) has a variety of liver-protective effects through the suppression of inflammatory mediators including tumor necrosis factor (TNF)-alpha and inducible nitric oxide synthase (iNOS).	Thioctic Acid	43-60	nitric oxide synthase 2	Rattus norvegicus	245-249	
25266599-1	2015	BACKGROUND: Recent evidence indicates that alpha-lipoic acid (alpha-LA) has a variety of liver-protective effects through the suppression of inflammatory mediators including tumor necrosis factor (TNF)-alpha and inducible nitric oxide synthase (iNOS).	Thioctic Acid	62-70	nitric oxide synthase 2	Rattus norvegicus	212-243	
25266599-1	2015	BACKGROUND: Recent evidence indicates that alpha-lipoic acid (alpha-LA) has a variety of liver-protective effects through the suppression of inflammatory mediators including tumor necrosis factor (TNF)-alpha and inducible nitric oxide synthase (iNOS).	Thioctic Acid	62-70	nitric oxide synthase 2	Rattus norvegicus	245-249	
23403734-4	2013	The ALA-treated group had similar bladder weights, collagen levels and TUNEL positivity and decreased iNOS levels compared with the control group, while the silymarin group exhibited further differences.	Thioctic Acid	4-7	nitric oxide synthase 2	Rattus norvegicus	102-106	
23489699-6	2013	Similarly, eyes sections from rats pre-treated with ALA and SOD showed reduced differential expression of inducible nitric oxide synthase (iNOS) and of caspase-3 in compared to normally-fed/MTC-inoculated cases.	Thioctic Acid	52-55	nitric oxide synthase 2	Rattus norvegicus	139-143	
22212728-0	2012	alpha-lipoic acid prevents the induction of iNOS gene expression through destabilization of its mRNA in proinflammatory cytokine-stimulated hepatocytes.	Thioctic Acid	0-17	nitric oxide synthase 2	Rattus norvegicus	44-48	
22212728-3	2012	We hypothesized that inhibition of iNOS induction underlies the protective effects of alpha-LA on the liver.	Thioctic Acid	86-94	nitric oxide synthase 2	Rattus norvegicus	35-39	
22212728-4	2012	The objective was to investigate whether alpha-LA directly influences iNOS induction in cultured hepatocytes, which is used as a simple in vitro injury model, and the mechanism involved.	Thioctic Acid	41-49	nitric oxide synthase 2	Rattus norvegicus	70-74	
21073761-9	2011	ALA significantly inhibited the ability of CAR to induce: (1) the degree of acute inflammation, (2) the rise in MPx activity, (3) the increases of GST and iNOS activities and the amount of LPO and (4) the decreases of GPx, GR and SOD activities and the amount of GSH.	Thioctic Acid	0-3	nitric oxide synthase 2	Rattus norvegicus	155-159	
18191078-8	2008	iNOS and eNOS increased in diabetic animals, and ALA prevented iNOS increment in lung tissues.	Thioctic Acid	49-52	nitric oxide synthase 2	Rattus norvegicus	63-67