PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34118221-10 2021 This study suggests that ALA priming may improve the therapeutic potential of ADSCs against chronic liver problems by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream antioxidant factors heme oxygenase 1 (HO-1) and quinone acceptor oxidoreductase-1 (NQO1). Thioctic Acid 25-28 NFE2 like bZIP transcription factor 2 Homo sapiens 133-176 34118221-10 2021 This study suggests that ALA priming may improve the therapeutic potential of ADSCs against chronic liver problems by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream antioxidant factors heme oxygenase 1 (HO-1) and quinone acceptor oxidoreductase-1 (NQO1). Thioctic Acid 25-28 NFE2 like bZIP transcription factor 2 Homo sapiens 178-182 35052616-1 2022 Hybrids based on an aza-analogue of CGP37157, a mitochondrial Na+/Ca2+ exchanger antagonist, and lipoic acid were obtained in order to combine in a single molecule the antioxidant and NRF2 induction properties of lipoic acid and the neuroprotective activity of CGP37157. Thioctic Acid 97-108 NFE2 like bZIP transcription factor 2 Homo sapiens 184-188 34211631-0 2021 alpha-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells. Thioctic Acid 0-17 NFE2 like bZIP transcription factor 2 Homo sapiens 33-37 35563167-8 2022 Many agents, including lipoic acid, melatonin, thymoquinone, astaxanthin, and crucifera-derived sulforaphane, can promote Nrf2 activity. Thioctic Acid 23-34 NFE2 like bZIP transcription factor 2 Homo sapiens 122-126 35052616-1 2022 Hybrids based on an aza-analogue of CGP37157, a mitochondrial Na+/Ca2+ exchanger antagonist, and lipoic acid were obtained in order to combine in a single molecule the antioxidant and NRF2 induction properties of lipoic acid and the neuroprotective activity of CGP37157. Thioctic Acid 213-224 NFE2 like bZIP transcription factor 2 Homo sapiens 184-188 33113440-7 2021 In addition, we noted significant upregulation of Nrf2 mRNA and protein expression of and mRNA expression of its Downstream Genes (GPx1, NQO1, and GCLC), as well as significant downregulation of Keap1 mRNA expression in testicular tissue of aged roosters with ALA supplementation. Thioctic Acid 260-263 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 33671655-6 2021 Furthermore, ALA and DHLA upregulated the expression of survival-related proteins mTOR (mammalian target of rapamycin), Akt (protein kinase B), and Nrf2 (nuclear factor erythroid 2-related factor 2) in PC12 cells, which were previously downregulated by metal exposure. Thioctic Acid 13-16 NFE2 like bZIP transcription factor 2 Homo sapiens 148-152 33671655-6 2021 Furthermore, ALA and DHLA upregulated the expression of survival-related proteins mTOR (mammalian target of rapamycin), Akt (protein kinase B), and Nrf2 (nuclear factor erythroid 2-related factor 2) in PC12 cells, which were previously downregulated by metal exposure. Thioctic Acid 13-16 NFE2 like bZIP transcription factor 2 Homo sapiens 154-197 33671655-7 2021 In contrast, in Caco-2 cells, upon co-exposure to metals and ALA, Nrf2 was upregulated and cleaved PARP-1 (poly (ADP-ribose) polymerase-1) was downregulated. Thioctic Acid 61-64 NFE2 like bZIP transcription factor 2 Homo sapiens 66-70 33113440-10 2021 In conclusion, dietary ALA supplementation enhanced the testicular antioxidant capacity through the Nrf2-signaling pathway, exerted anti-apoptotic effects, and improved the reproductive performance of aged roosters. Thioctic Acid 23-26 NFE2 like bZIP transcription factor 2 Homo sapiens 100-104 30758914-10 2019 ALA treatment decreased ROS production in UPM-exposed fibroblasts via the Nrf2, HO-1, and NQO-1 pathways. Thioctic Acid 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 74-78 31693218-1 2020 Two multitarget hybrids, derived from an aza-analogue of CGP37157, a mitochondrial Na+ /Ca2+ exchanger antagonist, and lipoic acid were designed in order to combine in a single molecule the antioxidant and Nrf2 induction properties of lipoic acid and the neuroprotective activity of CGP37157. Thioctic Acid 119-130 NFE2 like bZIP transcription factor 2 Homo sapiens 206-210 32061150-0 2020 alpha-Lipoic acid protects against microcystin-LR induced hepatotoxicity through regeneration of glutathione via activation of Nrf2. Thioctic Acid 0-17 NFE2 like bZIP transcription factor 2 Homo sapiens 127-131 32061150-2 2020 Alpha-lipoic acid (alpha-LA) is a super antioxidant that can induce the synthesis of antioxidants, such as glutathione (GSH), by nuclear factor erythroid 2-related factor 2 (Nrf2). Thioctic Acid 0-17 NFE2 like bZIP transcription factor 2 Homo sapiens 129-172 32061150-2 2020 Alpha-lipoic acid (alpha-LA) is a super antioxidant that can induce the synthesis of antioxidants, such as glutathione (GSH), by nuclear factor erythroid 2-related factor 2 (Nrf2). Thioctic Acid 0-17 NFE2 like bZIP transcription factor 2 Homo sapiens 174-178 32061150-2 2020 Alpha-lipoic acid (alpha-LA) is a super antioxidant that can induce the synthesis of antioxidants, such as glutathione (GSH), by nuclear factor erythroid 2-related factor 2 (Nrf2). Thioctic Acid 19-27 NFE2 like bZIP transcription factor 2 Homo sapiens 129-172 32061150-2 2020 Alpha-lipoic acid (alpha-LA) is a super antioxidant that can induce the synthesis of antioxidants, such as glutathione (GSH), by nuclear factor erythroid 2-related factor 2 (Nrf2). Thioctic Acid 19-27 NFE2 like bZIP transcription factor 2 Homo sapiens 174-178 32061150-8 2020 alpha-LA can mediate GSH regeneration through the Nrf2 pathway under the action of glutathione reductase in MC-LR cell lines. Thioctic Acid 0-8 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 32061150-9 2020 Furthermore, the data also showed that alpha-LA-induced cytoprotection against MC-LR is associated with Nrf2 mediate pathway in vivo. Thioctic Acid 39-47 NFE2 like bZIP transcription factor 2 Homo sapiens 104-108 31877176-0 2019 alpha-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway. Thioctic Acid 0-17 NFE2 like bZIP transcription factor 2 Homo sapiens 80-84 31319135-4 2019 Their transcriptional, as well as translational blockage of Nrf2 expression, was verified by using a proteasomal inhibitor (MG132) and well-known Nrf2 activator (alpha-lipoic acid (ALA)). Thioctic Acid 162-179 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 31319135-4 2019 Their transcriptional, as well as translational blockage of Nrf2 expression, was verified by using a proteasomal inhibitor (MG132) and well-known Nrf2 activator (alpha-lipoic acid (ALA)). Thioctic Acid 181-184 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 31319135-4 2019 Their transcriptional, as well as translational blockage of Nrf2 expression, was verified by using a proteasomal inhibitor (MG132) and well-known Nrf2 activator (alpha-lipoic acid (ALA)). Thioctic Acid 181-184 NFE2 like bZIP transcription factor 2 Homo sapiens 146-150 31319135-5 2019 Reduced expression of NADPH dehydrogenase quinone 1 (NQO-1) and heme oxygenase 1 (HO-1) genes, which are well-characterized downstream targets of Nrf2-mediated transactivation, was also confirmed by using ALA and another Nrf2 activator, marliolide. Thioctic Acid 205-208 NFE2 like bZIP transcription factor 2 Homo sapiens 146-150 31319135-9 2019 These data suggest a possibility for activation of Nrf2-independent ROS detoxification pathways by either ALA or marliolide. Thioctic Acid 106-109 NFE2 like bZIP transcription factor 2 Homo sapiens 51-55 30758914-13 2019 ALA treatment inhibited this increase via the Nrf2 pathway, suggesting that ALA may have a protective effect against rhinitis caused by ROS expression induced by exposure to UPM. Thioctic Acid 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 46-50 30758914-13 2019 ALA treatment inhibited this increase via the Nrf2 pathway, suggesting that ALA may have a protective effect against rhinitis caused by ROS expression induced by exposure to UPM. Thioctic Acid 76-79 NFE2 like bZIP transcription factor 2 Homo sapiens 46-50 30728952-5 2018 The translocation of Nrf2 to the nucleus after exposure of HepG2 cells to the extracts and controls (alpha-lipoic acid, curcumin and hydrogen peroxide) was evaluated using the Nrf2 transcription factor kit. Thioctic Acid 101-118 NFE2 like bZIP transcription factor 2 Homo sapiens 21-25 30096293-0 2018 Alpha-lipoic acid, but not di-hydrolipoic acid, activates Nrf2 response in primary human umbilical-vein endothelial cells and protects against TNF-alpha induced endothelium dysfunction. Thioctic Acid 0-17 NFE2 like bZIP transcription factor 2 Homo sapiens 58-62 30096293-6 2018 The electrophilic nature of oxidized nucleophilic molecules, including alpha-lipoic acid, renders more plausible a mechanism based on the ability to activate Nrf2/EpRE mediated hormetic response. Thioctic Acid 71-88 NFE2 like bZIP transcription factor 2 Homo sapiens 158-162 30096293-7 2018 In this study, we demonstrate that nmolar concentrations of oxidized alpha-lipoic acid, but not dehydrolipoic acid, protect human umbilical primary endothelial cells (HUVEC) from TNF-alpha induced dysfunction, inhibit NF-kappaB activation and block apoptosis following the activation of Nrf2 transcription factor. Thioctic Acid 69-86 NFE2 like bZIP transcription factor 2 Homo sapiens 287-291 28349254-7 2018 The HS-induced increase in Nrf2 gene expression as well as the Nrf2 nuclear translocation was impeded by ALA. Thioctic Acid 105-108 NFE2 like bZIP transcription factor 2 Homo sapiens 27-31 28349254-7 2018 The HS-induced increase in Nrf2 gene expression as well as the Nrf2 nuclear translocation was impeded by ALA. Thioctic Acid 105-108 NFE2 like bZIP transcription factor 2 Homo sapiens 63-67 28366867-6 2017 ALA activates Nrf2 pathway leading to GSH increment. Thioctic Acid 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 28262510-0 2017 Regeneration of glutathione by alpha-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity. Thioctic Acid 31-48 NFE2 like bZIP transcription factor 2 Homo sapiens 53-57 28262510-5 2017 Addition of alpha-LA to cadmium-treated cells reactivated Nrf2 and regenerated GSH through elevating the Nrf2-downstream genes gamma-glutamate-cysteine ligase (gamma-GCL) and GR, both of which are key enzymes for GSH synthesis. Thioctic Acid 12-20 NFE2 like bZIP transcription factor 2 Homo sapiens 58-62 28262510-5 2017 Addition of alpha-LA to cadmium-treated cells reactivated Nrf2 and regenerated GSH through elevating the Nrf2-downstream genes gamma-glutamate-cysteine ligase (gamma-GCL) and GR, both of which are key enzymes for GSH synthesis. Thioctic Acid 12-20 NFE2 like bZIP transcription factor 2 Homo sapiens 105-109 27343752-0 2016 alpha-Lipoic acid protects against the cytotoxicity and oxidative stress induced by cadmium in HepG2 cells through regeneration of glutathione by glutathione reductase via Nrf2/ARE signaling pathway. Thioctic Acid 0-17 NFE2 like bZIP transcription factor 2 Homo sapiens 172-176 27292272-3 2016 The largest part of the effects of ALA/DHLA couple can be explained by a specific stimulatory activity on Nrf2-dependent gene transcription and by the inhibition of NF-kB activity. Thioctic Acid 35-38 NFE2 like bZIP transcription factor 2 Homo sapiens 106-110 27343752-3 2016 In the present study, we investigated if alpha-LA replenished rGSH by GR via Nrf2/ARE signaling pathway in cadmium-treated HepG2 cells. Thioctic Acid 41-49 NFE2 like bZIP transcription factor 2 Homo sapiens 77-81 27343752-5 2016 alpha-LA regenerated rGSH by activating Nrf2 signaling pathway via promoting the nuclear translocation of Nrf2, which upregulates the transcription of GR, and thus increased the activity of GR. Thioctic Acid 0-8 NFE2 like bZIP transcription factor 2 Homo sapiens 40-44 27343752-5 2016 alpha-LA regenerated rGSH by activating Nrf2 signaling pathway via promoting the nuclear translocation of Nrf2, which upregulates the transcription of GR, and thus increased the activity of GR. Thioctic Acid 0-8 NFE2 like bZIP transcription factor 2 Homo sapiens 106-110 27343752-6 2016 Our results indicated that alpha-LA was an effective agent to antagonize the oxidative stress and alleviate the cytotoxicity in cadmium-treated HepG2 cells by regenerating rGSH through activating Nrf2 signaling pathway. Thioctic Acid 27-35 NFE2 like bZIP transcription factor 2 Homo sapiens 196-200 26299964-7 2015 Furthermore, alpha lipoic acid (ALA), a non-dispensable mitochondrial cofactor, upregulates PGC-1alpha-dependent TERT and the cytoprotective Nrf-2-mediated antioxidant/electrophile-responsive element (ARE/ERE) signaling cascades, and counteracts high-fat-diet-induced, age-dependent arteriopathy. Thioctic Acid 13-30 NFE2 like bZIP transcription factor 2 Homo sapiens 141-146 26299964-7 2015 Furthermore, alpha lipoic acid (ALA), a non-dispensable mitochondrial cofactor, upregulates PGC-1alpha-dependent TERT and the cytoprotective Nrf-2-mediated antioxidant/electrophile-responsive element (ARE/ERE) signaling cascades, and counteracts high-fat-diet-induced, age-dependent arteriopathy. Thioctic Acid 32-35 NFE2 like bZIP transcription factor 2 Homo sapiens 141-146 25123628-0 2014 Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. Thioctic Acid 0-17 NFE2 like bZIP transcription factor 2 Homo sapiens 126-130 23573137-6 2013 Interestingly, treatment with ALA significantly increased nuclear factor-erythroid 2-related factor 2 (Nrf2) activation and HO-1 expression in lungs of ALI. Thioctic Acid 30-33 NFE2 like bZIP transcription factor 2 Homo sapiens 103-107 23188707-7 2013 The mechanism(s) by which known Nrf2 activators, such as the natural chemopreventive compounds SF and lipoic acid, protect against the deleterious effects caused by arsenic will also be discussed. Thioctic Acid 102-113 NFE2 like bZIP transcription factor 2 Homo sapiens 32-36 23573137-6 2013 Interestingly, treatment with ALA significantly increased nuclear factor-erythroid 2-related factor 2 (Nrf2) activation and HO-1 expression in lungs of ALI. Thioctic Acid 30-33 NFE2 like bZIP transcription factor 2 Homo sapiens 58-101 22521877-0 2012 Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response. Thioctic Acid 46-57 NFE2 like bZIP transcription factor 2 Homo sapiens 16-20 21787596-4 2010 We analyzed the effect of ALA pretreatment on Nrf2-responsive gene expression of HepG2 cells exposed to As(3+). Thioctic Acid 26-29 NFE2 like bZIP transcription factor 2 Homo sapiens 46-50 21787596-0 2010 Alpha-lipoic acid regulates heme oxygenase gene expression and nuclear Nrf2 activation as a mechanism of protection against arsenic exposure in HepG2 cells. Thioctic Acid 0-17 NFE2 like bZIP transcription factor 2 Homo sapiens 71-75 21787596-7 2010 ALA prevented the strong expression of heme oxygenase by As(3+) exposure (from 35- to 5-times of control cells), which correlated with the reduction of Nrf2 observed in As(3+) group. Thioctic Acid 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 152-156 21787596-8 2010 ALA pretreatment can down-modulate the response mediated by Nrf2 and provide protection to As(3+) exposed HepG2 cells. Thioctic Acid 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 16123320-0 2005 Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells. Thioctic Acid 0-17 NFE2 like bZIP transcription factor 2 Homo sapiens 69-112 18813798-0 2008 Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by alpha-lipoic acid in human leukemia HL-60 cells. Thioctic Acid 99-116 NFE2 like bZIP transcription factor 2 Homo sapiens 80-84 16123320-10 2005 Pretreatment with SB203580, a p38 mitogen-activated protein kinase inhibitor, reduced ALA-induced HO-1 mRNA expression by 75% and inhibited ALA-induced Nrf2 binding to the HO-1 ARE. Thioctic Acid 140-143 NFE2 like bZIP transcription factor 2 Homo sapiens 152-156 16123320-11 2005 CONCLUSIONS: These results demonstrate that ALA induces HO-1 expression in THP-1 monocytic cells via Nrf2 and p38. Thioctic Acid 44-47 NFE2 like bZIP transcription factor 2 Homo sapiens 101-105 16123320-8 2005 ALA stimulated translocation of the transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) into the nucleus and binding to a human HO-1 antioxidant response element (ARE) by 30 minutes. Thioctic Acid 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 57-100 16123320-8 2005 ALA stimulated translocation of the transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) into the nucleus and binding to a human HO-1 antioxidant response element (ARE) by 30 minutes. Thioctic Acid 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 102-106 16123320-9 2005 A dominant-negative Nrf2 inhibitor reduced ALA-induced HO-1 mRNA expression by 66%. Thioctic Acid 43-46 NFE2 like bZIP transcription factor 2 Homo sapiens 20-24