PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32090494-0	2020	Alpha-lipoic acid inhibits lung cancer growth via mTOR-mediated autophagy inhibition.	Thioctic Acid	0-17	mechanistic target of rapamycin kinase	Homo sapiens	50-54	
33671655-6	2021	Furthermore, ALA and DHLA upregulated the expression of survival-related proteins mTOR (mammalian target of rapamycin), Akt (protein kinase B), and Nrf2 (nuclear factor erythroid 2-related factor 2) in PC12 cells, which were previously downregulated by metal exposure.	Thioctic Acid	13-16	mechanistic target of rapamycin kinase	Homo sapiens	82-86	
33671655-6	2021	Furthermore, ALA and DHLA upregulated the expression of survival-related proteins mTOR (mammalian target of rapamycin), Akt (protein kinase B), and Nrf2 (nuclear factor erythroid 2-related factor 2) in PC12 cells, which were previously downregulated by metal exposure.	Thioctic Acid	13-16	mechanistic target of rapamycin kinase	Homo sapiens	88-117	
30964187-13	2019	However, acting on the mTOR pathway, alpha-LA improved cognitive function and led to hippocampal cell survival.	Thioctic Acid	37-45	mechanistic target of rapamycin kinase	Homo sapiens	23-27	
30986422-0	2019	Alpha-lipoic acid alleviated 6-OHDA-induced cell damage by inhibiting AMPK/mTOR mediated autophagy.	Thioctic Acid	0-17	mechanistic target of rapamycin kinase	Homo sapiens	75-79	
30986422-8	2019	Furthermore, we found that ALA inhibited AMPK phosphorylation while activated mTOR phosphorylation thereby blocking AMPK/mTOR signaling pathway involved autophagy.	Thioctic Acid	27-30	mechanistic target of rapamycin kinase	Homo sapiens	78-82	
30986422-8	2019	Furthermore, we found that ALA inhibited AMPK phosphorylation while activated mTOR phosphorylation thereby blocking AMPK/mTOR signaling pathway involved autophagy.	Thioctic Acid	27-30	mechanistic target of rapamycin kinase	Homo sapiens	121-125	
30986422-9	2019	In conclusion, ALA alleviated 6-OHDA induced cell injury possibly by inhibiting autophagy mediated by AMPK/mTOR pathway.	Thioctic Acid	15-18	mechanistic target of rapamycin kinase	Homo sapiens	107-111	
22975849-8	2013	Regarding Akt/GSK-3beta downstream targets, antipsychotics increased beta-catenin levels, whereas (+-)-alpha-lipoic acid induced an elevation of mTOR activation.	Thioctic Acid	98-120	mechanistic target of rapamycin kinase	Homo sapiens	145-149	
27852394-1	2016	Objective: To investigate whether alpha-lipoic acid (ALA) regulates autophagy in the pathogenesis of colitis through the mammalian target of rapamycin (mTOR) signaling pathway.	Thioctic Acid	34-51	mechanistic target of rapamycin kinase	Homo sapiens	121-150	
27852394-1	2016	Objective: To investigate whether alpha-lipoic acid (ALA) regulates autophagy in the pathogenesis of colitis through the mammalian target of rapamycin (mTOR) signaling pathway.	Thioctic Acid	34-51	mechanistic target of rapamycin kinase	Homo sapiens	152-156	
27852394-1	2016	Objective: To investigate whether alpha-lipoic acid (ALA) regulates autophagy in the pathogenesis of colitis through the mammalian target of rapamycin (mTOR) signaling pathway.	Thioctic Acid	53-56	mechanistic target of rapamycin kinase	Homo sapiens	121-150	
27852394-1	2016	Objective: To investigate whether alpha-lipoic acid (ALA) regulates autophagy in the pathogenesis of colitis through the mammalian target of rapamycin (mTOR) signaling pathway.	Thioctic Acid	53-56	mechanistic target of rapamycin kinase	Homo sapiens	152-156	
30251691-6	2018	ALA treatment could increase H2S level, which reduced the autophagy-related index and activation of the 5"-monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway, thereby protecting vascular function in rats with T2DM.	Thioctic Acid	0-3	mechanistic target of rapamycin kinase	Homo sapiens	153-182	
30251691-6	2018	ALA treatment could increase H2S level, which reduced the autophagy-related index and activation of the 5"-monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway, thereby protecting vascular function in rats with T2DM.	Thioctic Acid	0-3	mechanistic target of rapamycin kinase	Homo sapiens	184-188	
30251691-11	2018	ALA may have a protective effect on VSMCs in T2DM by elevating H2S level and downregulating autophagy via the AMPK/mTOR pathway.	Thioctic Acid	0-3	mechanistic target of rapamycin kinase	Homo sapiens	115-119	
26463583-5	2016	ALA suppressed thyroid cancer cell proliferation through activation of AMPK and subsequent down-regulation of mammalian target of rapamycin (mTOR)-S6 signaling pathway.	Thioctic Acid	0-3	mechanistic target of rapamycin kinase	Homo sapiens	110-139	
26463583-5	2016	ALA suppressed thyroid cancer cell proliferation through activation of AMPK and subsequent down-regulation of mammalian target of rapamycin (mTOR)-S6 signaling pathway.	Thioctic Acid	0-3	mechanistic target of rapamycin kinase	Homo sapiens	141-145