PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18385940-9 2008 alpha-Lipoic acid significantly promoted the expression of NF-kappaB while decreasing the expression of Bax and the activities of caspase-3 and-9 without significantly affecting the Bcl-2 level. Thioctic Acid 0-17 BCL2 associated X, apoptosis regulator Homo sapiens 104-107 20580704-5 2010 We observed that alpha-lipoic acid is able to scavenge reactive oxygen species in MCF-7 cells and that the reduction of reactive oxygen species is followed by cell growth arrest in the G1 phase of the cell cycle, via the specific inhibition of Akt pathway and the up-regulation of the cyclin-dependent kinase inhibitor p27(kip1), and by apoptosis, via changes of the ratio of the apoptotic-related protein Bax/Bcl-2. Thioctic Acid 17-34 BCL2 associated X, apoptosis regulator Homo sapiens 406-409 20098578-8 2009 However, Bax protein and mRNA expressions were increased in cells treated with alpha-lipoic acid (P < 0.05). Thioctic Acid 79-96 BCL2 associated X, apoptosis regulator Homo sapiens 9-12 22796564-7 2012 Furthermore, treatment with ALA down-regulated the Bax expression and the release of cytochrome c and AIF translocation, but up-regulated the Bcl-2 expression in SCs. Thioctic Acid 28-31 BCL2 associated X, apoptosis regulator Homo sapiens 51-54 17917164-1 2007 In this study, we evaluated the effect of lipoic acid (LA) and N-acetyl cysteine (NAC) on oxidative [4-hydroxy-2-nonenal, N(epsilon)-(carboxymethyl)lysine and heme oxygenase-1] and apoptotic (caspase 9 and Bax) markers in fibroblasts from patients with Alzheimer disease (AD) and age-matched and young controls. Thioctic Acid 42-53 BCL2 associated X, apoptosis regulator Homo sapiens 206-209 32652098-1 2020 The aim of this study was to examine the effects of alpha lipoic acid (ALA) supplementation during semen cryopreservation on the sperm quality, chromatin integrity, oxidative stress, and expression level of BAX, BCL2, HSP70 and iNOS genes in semen samples obtained from infertile men with asthenoteratozoospermia. Thioctic Acid 52-69 BCL2 associated X, apoptosis regulator Homo sapiens 207-210 15735709-6 2005 Bax activation by As(2)O(3) seemed to require stress-induced intracellular reactive oxygen species (ROS), since the ROS scavengers (N-acetyl-L-cysteine and lipoic acid) could completely block the conformational change and translocation of Bax from cytosol to mitochondria. Thioctic Acid 156-167 BCL2 associated X, apoptosis regulator Homo sapiens 0-3 15735709-6 2005 Bax activation by As(2)O(3) seemed to require stress-induced intracellular reactive oxygen species (ROS), since the ROS scavengers (N-acetyl-L-cysteine and lipoic acid) could completely block the conformational change and translocation of Bax from cytosol to mitochondria. Thioctic Acid 156-167 BCL2 associated X, apoptosis regulator Homo sapiens 239-242 32652098-1 2020 The aim of this study was to examine the effects of alpha lipoic acid (ALA) supplementation during semen cryopreservation on the sperm quality, chromatin integrity, oxidative stress, and expression level of BAX, BCL2, HSP70 and iNOS genes in semen samples obtained from infertile men with asthenoteratozoospermia. Thioctic Acid 71-74 BCL2 associated X, apoptosis regulator Homo sapiens 207-210 32652098-7 2020 During cryopreservation, treatment of semen with 0.02 mM of ALA, as the optimal concentration, significantly decreased DNA fragmentation and oxidative stress level (P < 0.05), protected the acrosome integrity, and led to insignificant reduction in BAX gene expression level and significant increase in expression level of BCL2, HSP70, and iNOS genes compared with control group. Thioctic Acid 60-63 BCL2 associated X, apoptosis regulator Homo sapiens 248-251 29022246-3 2018 In this study, we investigated the role of endogenous antioxidant alpha-lipoic acid (ALA) as ROSs scavenger in the OLGs loss and myelin degeneration during cuprizone (cup)-induced demyelination in the experimental model of MS. Our results have shown that ALA treatment significantly increased population of mature OLGs (MOG+ cells), as well as decreased oxidative stress (ROSs, COX-2 and PGE2) and apoptosis mediators (caspase-3 and Bax/Bcl2 ratio) in corpus callosum (CC). Thioctic Acid 85-88 BCL2 associated X, apoptosis regulator Homo sapiens 433-436 26414010-9 2015 Subacutely, alpha-lipoic acid treatment reduced proapoptotic markers Bax (t = 4.483, P < 0.05), caspase 12 (t = 6.157, P < 0.001), and caspase 3 (t = 4.573, P < 0.01) after repetitive blast, and reduced tau hyperphosphorylation indicated by decreased CP-13 and paired helical filament staining. Thioctic Acid 12-29 BCL2 associated X, apoptosis regulator Homo sapiens 69-72 31456915-9 2019 High doses of N2L and ALA also protected hRPE cells from BL-induced apoptosis, which was confirmed by Western blot analysis: BCL-2 expression significantly increased, while BAX and caspase-3 expression slightly decreased compared to the CG. Thioctic Acid 22-25 BCL2 associated X, apoptosis regulator Homo sapiens 173-176