PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31797693-8	2020	Moreover, ALA significantly reduced messenger RNA expression of LC3-II genes and triggered caspase-3 expression.	Thioctic Acid	10-13	caspase 3	Rattus norvegicus	91-100	
31687838-11	2020	In the CIS + ALA group, Bax, caspase 3, MDA, AST and ALT levels were decreased, whereas Bcl-2, SOD, CAT and GPx levels were increased compared to the CIS group.	Thioctic Acid	13-16	caspase 3	Rattus norvegicus	29-38	
33005594-11	2020	alpha-lipoic acid supplementation inhibited the expression levels of testicular caspase-3 mRNA levels and also its activity in linuron treated rats.	Thioctic Acid	0-17	caspase 3	Rattus norvegicus	80-89	
32127153-6	2020	Caspase-3 immunoreactivity in follicular cells was decreased in VCD + ALA group compared to VCD group.	Thioctic Acid	70-73	caspase 3	Rattus norvegicus	0-9	
30393023-10	2019	ALA and/or CoQ10 was proved to prevent apoptosis and degeneration of DRG neurons, which appears to be mediated by regulating the expression of caspase 3 and UCP2 proteins, inducing ATP and improving DN-induced changes in DRG neurons.	Thioctic Acid	0-3	caspase 3	Rattus norvegicus	143-152	
30632398-11	2019	In the ALA treated group, the levels of MDA, CAT and caspase-3 returned to near control levels.	Thioctic Acid	7-10	caspase 3	Rattus norvegicus	53-62	
29879626-15	2018	ALA exerted its antioxidant effect via Nrf2/HO-1 pathway as well as it showed anti-inflammatory and antiapoptotic effects by reducing TNF-alpha, iNOS, COX-2 and caspase-3 levels in liver tissue homogenate.	Thioctic Acid	0-3	caspase 3	Rattus norvegicus	161-170	
25514429-8	2015	Moreover, ALA significantly attenuated LPS-induced caspase-3 activation in cardiomyocytes and improved survival rate.	Thioctic Acid	10-13	caspase 3	Rattus norvegicus	51-60	
29500983-8	2018	Interestingly, ALA showed significant antiapoptotic effects through downregulation of Bax and Caspase-3 expression levels.	Thioctic Acid	15-18	caspase 3	Rattus norvegicus	94-103	
26055972-5	2015	ALA treatment resulted in a downregulation of caspase-3 expression, reduced the number of positive cells in the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay and improved neuronal survival.	Thioctic Acid	0-3	caspase 3	Rattus norvegicus	46-55	
26294909-4	2015	ALA also reduced the increased TUNEL-positive cells rate and the enhanced caspase-3 activity induced by MCAO/R.	Thioctic Acid	0-3	caspase 3	Rattus norvegicus	74-83	
21062633-5	2011	Cytosolic translocation of cytochrome c and subsequent activation of caspase-3 were reduced by lipoic acid treatment.	Thioctic Acid	95-106	caspase 3	Rattus norvegicus	69-78	
23193380-10	2012	Histological evaluation showed that alpha-lipoic acid pretreatment reduced testicular cell damage and decreased TUNEL and caspase-3-positive cells.	Thioctic Acid	36-53	caspase 3	Rattus norvegicus	122-131	
23489699-6	2013	Similarly, eyes sections from rats pre-treated with ALA and SOD showed reduced differential expression of inducible nitric oxide synthase (iNOS) and of caspase-3 in compared to normally-fed/MTC-inoculated cases.	Thioctic Acid	52-55	caspase 3	Rattus norvegicus	152-161	
33111558-14	2021	ALA pretreatment could reverse the effects of colistin-induced nephrotoxicity, partly through its suppressing effect on Nox4 and caspase-3, which in turn results in its antioxidant and antiapoptotic effect.	Thioctic Acid	0-3	caspase 3	Rattus norvegicus	129-138	
18923301-10	2008	alpha-Lipoic acid (100 mg/kg) given before the shock period attenuated vascular hyperpermeability, mitochondrial ROS formation, mitochondrial depolarization, cytochrome c release, and activation of caspase 3 (P < 0.05).	Thioctic Acid	0-17	caspase 3	Rattus norvegicus	198-207	
18096126-7	2008	ALA restored BAK (BH3)-induced collapse in mitochondrial membrane potential and decreased BAK (BH3)-induced cytochrome c release and caspase-3 activity.	Thioctic Acid	0-3	caspase 3	Rattus norvegicus	133-142	
34305580-5	2021	The altered levels of blood delta-aminolevulinic acid dehydratase (ALAD), immunoglobulins (IgA, IgG, IgM, and IgE), interleukins (IL-1beta, IL-4, and IL-6), caspase-3, and tumor necrosis factor (TNF-alpha) were attenuated by lipoic acid treatment.	Thioctic Acid	225-236	caspase 3	Rattus norvegicus	157-166	
35422650-9	2022	In both brain structures, ALA diminishes ceramide synthesis and caspase-3 activity.	Thioctic Acid	26-29	caspase 3	Rattus norvegicus	64-73	
33883914-13	2021	Both AS-IV and ALA can reduce mitochondrial damage, improve mitochondrial electron transport chain complex activity and mitochondrial membrane potential, and reduce the percentages of positive cells with DNA fragmentation and the expression of cleaved caspase-3 protein.	Thioctic Acid	15-18	caspase 3	Rattus norvegicus	252-261	
32921159-8	2021	Active caspase-3 protein expression induced by IS was decreased by ALA.	Thioctic Acid	67-70	caspase 3	Rattus norvegicus	7-16	
32825436-11	2020	CONCLUSION: ALA co-administration with VPA significantly improved the oxidative stress condition, histological and morphometric picture of the pancreas, and restored normal expression of related genes, including Nrf2, caspase-3, and Bcl-2.	Thioctic Acid	12-15	caspase 3	Rattus norvegicus	218-227	
32823851-11	2020	(+/-) and (-) thioctic acid injections enhanced caspase-3 activity in some organs, (-) enantiomer-treated animals displayed more marked organ toxicity signs.	Thioctic Acid	14-27	caspase 3	Rattus norvegicus	48-57