PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6617864-0	1983	Effect of succinylacetone on heme and cytochrome P450 synthesis in hepatocyte culture.	succinylacetone	10-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	38-53	
6617864-1	1983	The effects of succinylacetone, a tyrosine metabolite, on the hepatic biosynthesis of heme and cytochrome P450 were studied in primary culture of chick embryo hepatocytes.	succinylacetone	15-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	95-110	
6617864-2	1983	Succinylacetone potentiated the phenobarbital-mediated induction of delta-aminolevulinate synthase, strongly inhibited porphobilinogen synthase activity, reduced cellular heme concentration and impaired induction of cytochrome P450.	succinylacetone	0-15	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	216-231	
6617864-3	1983	Enhanced induction of delta-aminolevulinate synthase and decreased cytochrome P450 induction may be explained by the succinylacetone-mediated inhibition of porphobilinogen synthase and the subsequent depletion of intracellular heme, since these effects of succinylacetone were reversed by addition of heme.	succinylacetone	117-132	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	67-82	
6826727-7	1983	In cultured hepatocytes, succinylacetone also inhibited ALA dehydratase activity, decreased the cellular content of heme and cytochrome P-450, and greatly potentiated the induction response of ALA synthase to drugs such as phenobarbital, chemicals such as allylisopropylacetamide and 3,5-dicarbethoxy-1,4-dihydrocollidine, and natural steroids such as etiocholanolone.	succinylacetone	25-40	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	125-141