PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16838078-0	2006	Increased mutant frequencies in the HPRT gene locus of leukemia HL-60 cells treated with succinylacetone.	succinylacetone	89-104	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	36-40	
16838078-3	2006	The goal of this study is to evaluate the mutagenic potential of SA by determining the frequencies of somatic mutations in the hypoxanthine-guanine phosphoribosyl transferase (HPRT) reporter gene in HL-60 cells following treatment with the chemical.	succinylacetone	65-67	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	127-174	
16838078-3	2006	The goal of this study is to evaluate the mutagenic potential of SA by determining the frequencies of somatic mutations in the hypoxanthine-guanine phosphoribosyl transferase (HPRT) reporter gene in HL-60 cells following treatment with the chemical.	succinylacetone	65-67	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	176-180	
16838078-4	2006	Treatments of HL-60 cells with 500 micromol/L SA for 72 h, a condition generally used to inhibit the MPO activity, resulted in a significantly increased HPRT mutant frequency (HPRT-Mf), compared with the control of untreated cells (47.25 x 10(-6) versus 7.5 x 10(-6), respectively, p <0.01).	succinylacetone	46-48	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	153-157	
16838078-4	2006	Treatments of HL-60 cells with 500 micromol/L SA for 72 h, a condition generally used to inhibit the MPO activity, resulted in a significantly increased HPRT mutant frequency (HPRT-Mf), compared with the control of untreated cells (47.25 x 10(-6) versus 7.5 x 10(-6), respectively, p <0.01).	succinylacetone	46-48	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	176-180	
16838078-5	2006	Treatment of the cells with lower doses of SA also led to an increase in HPRT-Mf but this was significant only with 200 micromol/L (28.67 x 10(-6), p<0.05) and not with doses lower than 100 micromol/L (p0.05), compared with the control of untreated cells (7.5 x 10(-6)).	succinylacetone	43-45	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	73-77	
16838078-6	2006	These data show a dose-response increase in HPRT-Mf in HL-60 cells treated with SA, suggesting that this chemical causes mutations in the HPRT locus in these cells either directly or indirectly through its inhibition of the MPO activity.	succinylacetone	80-82	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	44-48	
16838078-6	2006	These data show a dose-response increase in HPRT-Mf in HL-60 cells treated with SA, suggesting that this chemical causes mutations in the HPRT locus in these cells either directly or indirectly through its inhibition of the MPO activity.	succinylacetone	80-82	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	138-142