PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22772944-3 2012 A high number of cases are associated with obesity, corticosteroid intake and a dysbalance in adrenocorticotropic hormone (ACTH)-cortisone metabolism. Cortisone 129-138 proopiomelanocortin Homo sapiens 94-121 28590513-0 2017 Diagnostic accuracy of increased urinary cortisol/cortisone ratio to differentiate ACTH-dependent Cushing"s syndrome. Cortisone 50-59 proopiomelanocortin Homo sapiens 83-87 22772944-3 2012 A high number of cases are associated with obesity, corticosteroid intake and a dysbalance in adrenocorticotropic hormone (ACTH)-cortisone metabolism. Cortisone 129-138 proopiomelanocortin Homo sapiens 123-127 3463439-3 1986 We propose that in these patients the 11 beta-HSD deficiency impairs the metabolism of cortisol to cortisone, resulting in a prolonged cortisol half-life, suppression of ACTH, and normal serum cortisol. Cortisone 99-108 proopiomelanocortin Homo sapiens 170-174 16551740-2 2006 In the rare cortisone reductase deficiency, impaired regeneration of active cortisol from inert cortisone by 11beta-hydroxysteroid dehydrogenase (11beta-HSD1) results in compensatory activation of ACTH secretion and adrenal hyperandrogenism. Cortisone 12-21 proopiomelanocortin Homo sapiens 197-201 11288760-10 2001 ACTH raised cortisol and B production from both specimens, and it lowered cortisone and DH-B yield. Cortisone 74-83 proopiomelanocortin Homo sapiens 0-4 9806762-5 1998 ACTH and angiotensin II evoked a marked rise in the secretion of cortisol and B, but unexpectedly depressed the release of cortisone and DH-B. Cortisone 123-132 proopiomelanocortin Homo sapiens 0-4 9806762-6 1998 ACTH also lowered the capacity of adrenal slices to convert [3H]cortisol to [3H]cortisone. Cortisone 80-89 proopiomelanocortin Homo sapiens 0-4 8668590-9 1995 Moreover vascular fragility resulting from pressure and minor traumas is known to be a cutaneous complication of hypercorticism; nevertheless the doses of cortisone administered to this patient were rather low and other clinical signs of steroid hyper-dosing were absent although cortisolemia assay at base and after stimulus with ACTH was not performed. Cortisone 155-164 proopiomelanocortin Homo sapiens 331-335 1337504-4 1992 The effect of ACTH on peripheral plasma cortisol/cortisone ratio was assessed in healthy volunteers during circadian rhythm, insulin induced hypoglycaemia, and infusions with exogenous ACTH or cortisol. Cortisone 49-58 proopiomelanocortin Homo sapiens 14-18 1337504-10 1992 Plasma cortisol/cortisone ratios were higher in ectopic ACTH syndrome than in other forms of Cushing"s syndrome. Cortisone 16-25 proopiomelanocortin Homo sapiens 56-60 1337504-12 1992 CONCLUSIONS: Peripheral conversion of cortisol to cortisone occurs mainly in the kidney and is inhibited by ACTH. Cortisone 50-59 proopiomelanocortin Homo sapiens 108-112 20925018-6 2010 When tested at different time points, ln(ACTH) at 10:00 to 12:00 h was negatively correlated with plasma cortisol between 08:30 and 12:00 h. Plasma cortisol was highly correlated to ln(salivary cortisol) most of the time points measured, but 30-60 min after intake of cortisone acetate the correlation disappeared. Cortisone 268-285 proopiomelanocortin Homo sapiens 41-45 15008243-10 2003 Our study demonstrates that the subdivision of the total daily dose of cortisone acetate in 3 administrations increases total UFC excretion and reduces plasma ACTH levels, thus improving the substitutive therapy. Cortisone 71-88 proopiomelanocortin Homo sapiens 159-163 9516061-3 1998 In contrast elevated plasma cortisol levels (adrenal adenoma or intravenous cortisol administration) in the presence of suppressed ACTH secretion leads to significant inhibition of the peripheral conversion of cortisol to cortisone. Cortisone 222-231 proopiomelanocortin Homo sapiens 131-135 4305375-5 1969 However parotid fluid cortisol plus cortisone rose from 0.8 to 2.6 mug/100 ml after ACTH and to only 2.2 after estrogen. Cortisone 36-45 proopiomelanocortin Homo sapiens 84-88 172768-5 1975 As a result of corticotrophin"s direct effect on the bronchial muscles and the mast cells, along with its stimulation of the adrenal cortex, treatment with ACTH has the advantage over the classic cortisone treatment of retaining the functional ability of the adrenal cortex and reducing the amount of cortisone needed. Cortisone 196-205 proopiomelanocortin Homo sapiens 156-160 172768-5 1975 As a result of corticotrophin"s direct effect on the bronchial muscles and the mast cells, along with its stimulation of the adrenal cortex, treatment with ACTH has the advantage over the classic cortisone treatment of retaining the functional ability of the adrenal cortex and reducing the amount of cortisone needed. Cortisone 301-310 proopiomelanocortin Homo sapiens 156-160 6289586-0 1982 ACTH suppression after oral administration of cortisone in Addisonian and adrenalectomized patients. Cortisone 46-55 proopiomelanocortin Homo sapiens 0-4 6254305-4 1980 The ACTH secretion was suppressed by cortisone administered perorally. Cortisone 37-46 proopiomelanocortin Homo sapiens 4-8 6255853-3 1980 Only trivial changes in cortisone level were detected in response to exercise, surgery, and ACTH, even though marked changes in cortisol level were simultaneously recorded. Cortisone 24-33 proopiomelanocortin Homo sapiens 92-96 207215-6 1978 Accordingly, from a practical and therapeutic point of view, it would be suitable, after removal of an adrenal tumour, especially of one with demonstrated ACTH-dependance, to suppress totally endogenous ACTH by cortisol or cortisone therapy, in order to reduce the occurence of corticotropin stimulation of possibly remaining malignant adrenal cells. Cortisone 223-232 proopiomelanocortin Homo sapiens 203-207 14006400-0 1962 Effects of a bacterial polysaccharide (Piromen) on the pituitary-adrenal axis: chronic cortisone blockade of Piromen-induced release of ACTH. Cortisone 87-96 proopiomelanocortin Homo sapiens 136-140 14410729-0 1960 [Evaluation of the corticotropic effect of ACTH on adrenal cortex atrophy caused by cortisone]. Cortisone 84-93 proopiomelanocortin Homo sapiens 43-47 13667240-0 1959 [Hypocalcic cataract with tetany during nephrosis treated with ACTH & cortisone]. Cortisone 74-83 proopiomelanocortin Homo sapiens 63-67 13644076-0 1959 [Cortisone & ACTH therapy of severe infections in children]. Cortisone 1-10 proopiomelanocortin Homo sapiens 17-21 13648544-0 1958 [Hematological side-effects in the treatment of dermatoses with ACTH & cortisone]. Cortisone 75-84 proopiomelanocortin Homo sapiens 64-68 13623463-0 1958 [Therapeutic effect of ACTH & cortisone on inflammatory infiltrations]. Cortisone 34-43 proopiomelanocortin Homo sapiens 23-27 13610242-0 1958 [Functional restoration of cortisone-atrophied adrenals with ACTH]. Cortisone 27-36 proopiomelanocortin Homo sapiens 61-65 13561413-0 1958 [Use of ACTH & cortisone in pediatrics]. Cortisone 19-28 proopiomelanocortin Homo sapiens 8-12 13601621-0 1958 [Changes in the blood picture in the treatment of chronic nonspecific polyarthritis with ACTH & cortisone]. Cortisone 100-109 proopiomelanocortin Homo sapiens 89-93 13615146-0 1958 [Total failure with cortisone & unexpected success with ACTH in a case of acute articular rheumatism in a child with severe carditis]. Cortisone 20-29 proopiomelanocortin Homo sapiens 60-64 4332888-0 1969 [Principles and limits of ACTH-cortisone therapy in neurology]. Cortisone 31-40 proopiomelanocortin Homo sapiens 26-30 4291183-0 1965 [Effect of ACTH on the phase of restitution of the adrenal cortex following long-term cortisone administration]. Cortisone 86-95 proopiomelanocortin Homo sapiens 11-15 13842204-0 1960 [Variations of adrenal reactivity to ACTH after arrest of a prolonged treatment by cortisone derivatives (deltacortisone) associated or not with depot ACTH or with testosterone]. Cortisone 83-92 proopiomelanocortin Homo sapiens 37-41 13816644-0 1959 [On ACTH-cortisone therapy of vascular purpura (Schoenlein-Henock-Glanzmann)]. Cortisone 9-18 proopiomelanocortin Homo sapiens 4-8 13643612-0 1959 [Internal therapeutic damage cuased by normal preparations with special reference to ACTH & cortisone]. Cortisone 96-105 proopiomelanocortin Homo sapiens 85-89 13631059-0 1959 Effects of exogenous adrenocorticotropic hormone (ACTH) upon pituitary ACTH concentration after prolonged cortisone treatment and stress. Cortisone 106-115 proopiomelanocortin Homo sapiens 21-48 13631059-0 1959 Effects of exogenous adrenocorticotropic hormone (ACTH) upon pituitary ACTH concentration after prolonged cortisone treatment and stress. Cortisone 106-115 proopiomelanocortin Homo sapiens 50-54 13631059-0 1959 Effects of exogenous adrenocorticotropic hormone (ACTH) upon pituitary ACTH concentration after prolonged cortisone treatment and stress. Cortisone 106-115 proopiomelanocortin Homo sapiens 71-75 13646206-0 1959 [Exophthalmos in the Graves-Basedow disease; its treatment with ACTH & cortisone]. Cortisone 75-84 proopiomelanocortin Homo sapiens 64-68 13529933-0 1957 [Death caused by cortisone & ACTH treatment; analysis of 18 cases]. Cortisone 17-26 proopiomelanocortin Homo sapiens 33-37 13511498-0 1957 [Use of ACTH & cortisone for infants]. Cortisone 19-28 proopiomelanocortin Homo sapiens 8-12 13454853-0 1957 [Psychic complications observed in children treated with cortisone & ACTH]. Cortisone 57-66 proopiomelanocortin Homo sapiens 73-77 13451703-0 1957 [Treatment of mumps orchitis with ACTH & cortisone]. Cortisone 45-54 proopiomelanocortin Homo sapiens 34-38 13406883-0 1957 Nonspecific cortisone effects from ACTH administration in advanced prostatic carcinoma. Cortisone 12-21 proopiomelanocortin Homo sapiens 35-39 13542307-0 1957 [Prolonged administration of cortisone & ACTH]. Cortisone 29-38 proopiomelanocortin Homo sapiens 45-49 13380854-0 1956 [ACTH- cortisone; present view on the use of ACTH and cortisone preparations with chronic arthritis]. Cortisone 7-16 proopiomelanocortin Homo sapiens 1-5 13401467-0 1956 Nonspecific cortisone effects from ACTH administration in advanced prostatic carcinoma. Cortisone 12-21 proopiomelanocortin Homo sapiens 35-39 13567129-0 1958 [Case of dermatomyositis treated by ACTH & cortisone]. Cortisone 47-56 proopiomelanocortin Homo sapiens 36-40 13568281-0 1958 [Therapeutic contribution of cortisone & ACTH to our pathogenic concept]. Cortisone 29-38 proopiomelanocortin Homo sapiens 45-49 13619212-0 1958 [Adrenal response to ACTH during prolonged therapy with cortisone (cortancyl) alone or with testosterone]. Cortisone 56-65 proopiomelanocortin Homo sapiens 21-25 13490572-0 1957 [Changes in blood & urinary adrenocortical steroid levels induced by ACTH & cortisone; their physiopathological significance in normal subjects & in adrenal cortex diseases]. Cortisone 84-93 proopiomelanocortin Homo sapiens 73-77 13446442-0 1957 A COMPARISON of cortisone and prednisone in treatment of rheumatoid arthritis; a report by the Joint Committee of the Medical Research Council and Nuffield Foundation on Clinical Trials of Cortisone, ACTH and other therapeutic measures in chronic rheumatic diseases. Cortisone 16-25 proopiomelanocortin Homo sapiens 200-204 13425181-0 1957 [Treatment of infantile eczema with ACTH & cortisone]. Cortisone 47-56 proopiomelanocortin Homo sapiens 36-40 13427992-0 1957 [Use of ACTH & cortisone in allergic otorhinolaryngological disorders]. Cortisone 19-28 proopiomelanocortin Homo sapiens 8-12 13522094-0 1957 [Studies on the behavior of serum proteins after the use of alteratives & ACTH & cortisone treatment in skin diseases]. Cortisone 89-98 proopiomelanocortin Homo sapiens 78-82 13480217-0 1957 [Use of cortisone, its derivatives & ACTH in rheumatic diseases]. Cortisone 8-17 proopiomelanocortin Homo sapiens 41-45 14365697-0 1955 Reduction of pituitary content of ACTH by cortisone. Cortisone 42-51 proopiomelanocortin Homo sapiens 34-38 14379693-0 1955 Psychological effects of ACTH cortisone. Cortisone 30-39 proopiomelanocortin Homo sapiens 25-29 13199465-0 1954 [Indications on ACTH on cortisone in ophthalmology]. Cortisone 24-33 proopiomelanocortin Homo sapiens 16-20 13421456-0 1955 [Considerations on two cases of purpura treated with ACTH & cortisone]. Cortisone 64-73 proopiomelanocortin Homo sapiens 53-57 13170994-0 1954 Inhibitory effect of cortisone upon the mobilization of adrenocorticotropic hormone (ACTH). Cortisone 21-30 proopiomelanocortin Homo sapiens 56-83 13170994-0 1954 Inhibitory effect of cortisone upon the mobilization of adrenocorticotropic hormone (ACTH). Cortisone 21-30 proopiomelanocortin Homo sapiens 85-89 13087773-0 1953 [Recent therapy of acute leukemia in children (folic acid antagonists and ACTH with cortisone)]. Cortisone 84-93 proopiomelanocortin Homo sapiens 74-78 13152964-0 1953 [Inhibition of secretion of ACTH with cortisone]. Cortisone 38-47 proopiomelanocortin Homo sapiens 28-32 13074444-0 1953 Psychotic reactions induced by corticotropin (ACTH) cortisone. Cortisone 52-61 proopiomelanocortin Homo sapiens 46-50 13050215-0 1953 Successful corticotropin (ACTH) therapy of Whipple"s disease refractory to cortisone. Cortisone 75-84 proopiomelanocortin Homo sapiens 26-30 13133588-0 1953 [Fatal hemorrhagic varicella during cortisone-ACTH treatment]. Cortisone 36-45 proopiomelanocortin Homo sapiens 46-50 13113060-0 1953 [Periarteritis nodosa; neurologic symptomatology and evaluation of ACTH-cortisone therapy]. Cortisone 72-81 proopiomelanocortin Homo sapiens 67-71 12978127-0 1952 [Influence of ACTH & thyroidectomy on adrenal adtrophy from cortisone]. Cortisone 64-73 proopiomelanocortin Homo sapiens 14-18 13019703-0 1953 The use of ACTH cortisone and salicylates in the treatment of acute rheumatic fever. Cortisone 16-25 proopiomelanocortin Homo sapiens 11-15 14925445-0 1952 TREATMENT of blood disorders with ACTH and cortisone; a preliminary report to the Medical Research Council by the Panel on the Haematological Applications of ACTH and Cortisone. Cortisone 43-52 proopiomelanocortin Homo sapiens 158-162 14925445-0 1952 TREATMENT of blood disorders with ACTH and cortisone; a preliminary report to the Medical Research Council by the Panel on the Haematological Applications of ACTH and Cortisone. Cortisone 167-176 proopiomelanocortin Homo sapiens 34-38 14925706-0 1951 [New cases of lupus erythematosus treated with ACTH & cortisone]. Cortisone 58-67 proopiomelanocortin Homo sapiens 47-51 14876419-0 1951 [Use of the 48 hour ACTH test in the detection of adrenal insufficiency due to prolonged cortisone therapy]. Cortisone 89-98 proopiomelanocortin Homo sapiens 20-24 14912550-0 1951 [Administration of cortisone & ACTH]. Cortisone 19-28 proopiomelanocortin Homo sapiens 35-39 14921498-0 1951 [Humoral modifications during applications of cortisone & ACTH in rheumatism]. Cortisone 46-55 proopiomelanocortin Homo sapiens 62-66 14841382-0 1951 Cutaneous side effects of ACTH cortisone and pregnenolone therapy. Cortisone 31-40 proopiomelanocortin Homo sapiens 26-30 14848703-11 1951 During prolonged cortisone therapy evidence of functional suppression of the adrenal cortices, as indicated by a decreased response of circulating eosinophils to exogenous ACTH, was present. Cortisone 17-26 proopiomelanocortin Homo sapiens 172-176 14903658-0 1951 [Adrenal insufficiency after prolonged treatment with cortisone detected by the 48 hour ACTH test]. Cortisone 54-63 proopiomelanocortin Homo sapiens 88-92 14816322-0 1951 [Cortisone-ACTH and tuberculosis]. Cortisone 1-10 proopiomelanocortin Homo sapiens 11-15 13291324-0 1955 [Experience with ACTH-cortisone therapy of chronic arthritis]. Cortisone 22-31 proopiomelanocortin Homo sapiens 17-21 14928633-0 1951 [Surgical aspects of the use of ACTH & cortisone]. Cortisone 43-52 proopiomelanocortin Homo sapiens 32-36 32151296-3 2021 We hypothesized that OB pregnancies would show increased placental 11beta hydroxysteroid dehydrogenase 2 (11beta-HSD2) that converts maternal cortisol to fetal cortisone as it crosses the placenta and increased 11beta-HSD system components responsible for peripheral tissue cortisol production, providing a mechanism for ACTH-independent increase in circulating fetal cortisol. Cortisone 160-169 proopiomelanocortin Homo sapiens 321-325 14893356-0 1951 Symposium on cortisone and ACTH: introductory remarks concerning the nature and effects of ACTH and cortisone. Cortisone 13-22 proopiomelanocortin Homo sapiens 91-95 14893361-0 1951 Symposium on cortisone and ACTH: the treatment of sarcoidosis with cortisone. Cortisone 67-76 proopiomelanocortin Homo sapiens 27-31 14893362-0 1951 Symposium on cortisone and ACTH: the clinical effects of ACTH and cortisone in tuberculosis. Cortisone 13-22 proopiomelanocortin Homo sapiens 57-61 14893362-0 1951 Symposium on cortisone and ACTH: the clinical effects of ACTH and cortisone in tuberculosis. Cortisone 66-75 proopiomelanocortin Homo sapiens 27-31