PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28087150-0 2017 Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1/2, and suppressing TNF-alpha expression in mice. N-Methylaspartate 24-28 tumor necrosis factor Mus musculus 126-135 31260687-9 2019 Besides, NMDA-induced ER stress strongly promoted pro-inflammatory cytokines synthesis (IL-1beta and TNF-alpha) in beta cells. N-Methylaspartate 9-13 tumor necrosis factor Mus musculus 101-110 28356707-9 2017 While NMDA treatment dramatically upregulated mRNAs of inflammatory cytokines (TNFalpha, IL-1beta, MCP-1, RANTES) in retinal homogenates, co-injection with JQ1 suppressed their upregulation by ~50%. N-Methylaspartate 6-10 tumor necrosis factor Mus musculus 79-87 28087150-6 2017 Additionally, an intravitreal injection of tumor necrosis factor-alpha (TNF-alpha) neutralizing antibody prevented NMDA-induced retinal neuronal cell death, and exogenous and endogenous apelin suppressed NMDA-induced upregulation of TNF-alpha in the retina. N-Methylaspartate 115-119 tumor necrosis factor Mus musculus 43-70 28087150-6 2017 Additionally, an intravitreal injection of tumor necrosis factor-alpha (TNF-alpha) neutralizing antibody prevented NMDA-induced retinal neuronal cell death, and exogenous and endogenous apelin suppressed NMDA-induced upregulation of TNF-alpha in the retina. N-Methylaspartate 115-119 tumor necrosis factor Mus musculus 72-81 27371735-4 2016 In cultured HASM cells, we assessed TNF (10 ng/ml, 48 h) effect on NMDA-R subunit abundance by quantitative PCR, confocal imaging, and immunoblotting. N-Methylaspartate 67-71 tumor necrosis factor Mus musculus 36-39 27791020-3 2016 We here show the therapeutic potential of selective inhibition of TNFR1 and activation of TNFR2 by ATROSAB, a TNFR1-selective antagonistic antibody, and EHD2-scTNFR2, an agonistic TNFR2-selective TNF, respectively, in a mouse model of NMDA-induced acute neurodegeneration. N-Methylaspartate 235-239 tumor necrosis factor Mus musculus 66-69 27371735-6 2016 Measuring intracellular Ca(2+) flux in Fura-2-loaded HASM cultures, we observed that TNF exposure enhanced cytosolic Ca(2+) mobilization and changed the temporal pattern of Ca(2+) flux in individual myocytes induced by NMDA, an NMDA-R selective analog of glutamate. N-Methylaspartate 219-223 tumor necrosis factor Mus musculus 85-88 27371735-8 2016 However, NMDA acted as a bronchodilator in TCLS from house dust mice-challenged mice and in allergen-naive TCLS subjected to TNF exposure. N-Methylaspartate 9-13 tumor necrosis factor Mus musculus 125-128 24283717-8 2014 NMDA induced glial activation, expression of TNF-alpha and IL-1beta that co-localized with Muller cells in WT but not TKO mice. N-Methylaspartate 0-4 tumor necrosis factor Mus musculus 45-54 25613943-13 2015 The TO90 also inhibited the increase of p-p38 MAPK and proinflammatory cytokine TNF-alpha after NMDA injection. N-Methylaspartate 96-100 tumor necrosis factor Mus musculus 80-89 24283717-9 2014 In parallel, NMDA triggered the expression of NOD-like receptor protein (NLRP3), activation of caspase-1, and release of IL-1beta and TNF-alpha in primary WT but not TKO Muller cultures. N-Methylaspartate 13-17 tumor necrosis factor Mus musculus 134-143 21159431-9 2011 TNF-alpha also increased N-methyl-d-aspartate (NMDA) currents in lamina II neurons, and this increase was abolished in TNFR1-KO mice but retained in TNFR2-KO mice. N-Methylaspartate 25-45 tumor necrosis factor Mus musculus 0-9 23094196-0 2012 Rapamycin Augments the NMDA-Mediated TNF Suppression of MRSA-Stimulated RAW264.7 Murine Macrophages. N-Methylaspartate 23-27 tumor necrosis factor Mus musculus 37-40 23094196-4 2012 The downstream effects of NMDA-mediated TNF suppression, specifically the PI3K/Akt and mTOR modulation, have not been described. N-Methylaspartate 26-30 tumor necrosis factor Mus musculus 40-43 23094196-9 2012 NMDA inhibition suppressed TNF secretion by almost a third compared to the no-ketamine control. N-Methylaspartate 0-4 tumor necrosis factor Mus musculus 27-30 23094196-10 2012 When NMDA substrate was added, the TNF secretion increased by 10%. N-Methylaspartate 5-9 tumor necrosis factor Mus musculus 35-38 23094196-16 2012 These findings suggest that NMDA-induced TNF suppression can be augmented by concurrent mTOR inhibition. N-Methylaspartate 28-32 tumor necrosis factor Mus musculus 41-44 21266054-8 2011 The NMDA inhibitors, MK-801 and APV, also suppressed macrophage TNF secretion after stimulation with either of the antibiotic-exposed CA-MRSA isolates, and the effect was not additive or synergistic with ketamine. N-Methylaspartate 4-8 tumor necrosis factor Mus musculus 64-67 21266054-9 2011 The addition of NMDA substrate augmented TNF secretion in response to the CA-MRSA bacteria, and the addition of APV suppressed the effect of NMDA in a dose-dependent fashion. N-Methylaspartate 16-20 tumor necrosis factor Mus musculus 41-44 21159431-9 2011 TNF-alpha also increased N-methyl-d-aspartate (NMDA) currents in lamina II neurons, and this increase was abolished in TNFR1-KO mice but retained in TNFR2-KO mice. N-Methylaspartate 47-51 tumor necrosis factor Mus musculus 0-9 20383154-7 2010 RvE1 also abolishes transient receptor potential vanilloid subtype-1 (TRPV1)- and TNF-alpha-induced excitatory postsynaptic current increases and TNF-alpha-evoked N-methyl-D-aspartic acid (NMDA) receptor hyperactivity in spinal dorsal horn neurons via inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway. N-Methylaspartate 163-187 tumor necrosis factor Mus musculus 146-155 19994584-4 2009 NMDA increased the expression of interleukin-1beta and TNF-alpha, and endothelial adhesion molecules, including ICAM-1, and induced leukocyte accumulation in the retinal vessels. N-Methylaspartate 0-4 tumor necrosis factor Mus musculus 55-64 17241124-2 2007 Previously, we demonstrated that glutamate and tumor necrosis factor alpha (TNFalpha) kill neurons via activation of the N-methyl-d-aspartate (NMDA) and TNFalpha receptors, respectively. N-Methylaspartate 121-141 tumor necrosis factor Mus musculus 47-74 17241124-2 2007 Previously, we demonstrated that glutamate and tumor necrosis factor alpha (TNFalpha) kill neurons via activation of the N-methyl-d-aspartate (NMDA) and TNFalpha receptors, respectively. N-Methylaspartate 121-141 tumor necrosis factor Mus musculus 76-84 17241124-2 2007 Previously, we demonstrated that glutamate and tumor necrosis factor alpha (TNFalpha) kill neurons via activation of the N-methyl-d-aspartate (NMDA) and TNFalpha receptors, respectively. N-Methylaspartate 143-147 tumor necrosis factor Mus musculus 47-74 17241124-2 2007 Previously, we demonstrated that glutamate and tumor necrosis factor alpha (TNFalpha) kill neurons via activation of the N-methyl-d-aspartate (NMDA) and TNFalpha receptors, respectively. N-Methylaspartate 143-147 tumor necrosis factor Mus musculus 76-84 17241124-4 2007 Stimulation of mouse cortical neuron cultures with TNFalpha results in a transient increase in NMDA receptor-dependent calcium influx that is additive with NMDA stimulation and inhibited by pre-treatment with the NMDA receptor antagonist, DL-2-amino-5-phosphonovaleric acid, or the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist, 6,7-dinitroquinoxaline-2,3-dione. N-Methylaspartate 95-99 tumor necrosis factor Mus musculus 51-59 17266736-7 2007 NMDA increased the expression of interleukin-1beta and TNF-alpha, and endothelial adhesion molecules, including ICAM-1, and induced leukocyte accumulation in the retinal vessels. N-Methylaspartate 0-4 tumor necrosis factor Mus musculus 55-64 14622092-3 2003 The inflammatory cytokine tumor necrosis factor alpha (TNFalpha) is also neuroprotective, however, in the presence of nicotine, neuroprotection against NMDA is abolished. N-Methylaspartate 152-156 tumor necrosis factor Mus musculus 26-53 14622092-3 2003 The inflammatory cytokine tumor necrosis factor alpha (TNFalpha) is also neuroprotective, however, in the presence of nicotine, neuroprotection against NMDA is abolished. N-Methylaspartate 152-156 tumor necrosis factor Mus musculus 55-63 14622092-6 2003 The mechanism of TNFalpha-mediated neuroprotection and antagonism by nicotine was independent of caspase 8 activation or nuclear factor kappa B translocation in neurons but C6-ceramide addition to neuronal cultures subsequently exposed to NMDA mimicked the neuroprotective effect of TNFalpha and, like TNFalpha, it was antagonized by cotreatment with nicotine. N-Methylaspartate 239-243 tumor necrosis factor Mus musculus 17-25