PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18025470-2 2007 To investigate the spectrum and mechanism of Ngb"s neuroprotective action, we studied the effect of transgenic overexpression of Ngb on NMDA and beta-amyloid (Abeta) toxicity in murine cortical neuron cultures in vitro and on the phenotype of Alzheimer"s disease (AD) transgenic (APP(Sw,Ind)) mice. N-Methylaspartate 136-140 neuroglobin Mus musculus 129-132 18025470-3 2007 Compared with cortical neuron cultures from wild-type mice, cultures from Ngb-overexpressing transgenic (Ngb-Tg mice) were resistant to the toxic effects of NMDA and Abeta(25-35), as measured by polarization of cell membrane lipid rafts, mitochondrial aggregation, lactate dehydrogenase release, and nuclear fragmentation. N-Methylaspartate 157-161 neuroglobin Mus musculus 74-77 18025470-3 2007 Compared with cortical neuron cultures from wild-type mice, cultures from Ngb-overexpressing transgenic (Ngb-Tg mice) were resistant to the toxic effects of NMDA and Abeta(25-35), as measured by polarization of cell membrane lipid rafts, mitochondrial aggregation, lactate dehydrogenase release, and nuclear fragmentation. N-Methylaspartate 157-161 neuroglobin Mus musculus 105-108 18025470-6 2007 Ngb may protect neurons from NMDA and Abeta toxicity by inhibiting the formation of a death-signaling membrane complex, and interventions that increase Ngb expression could have therapeutic application in AD and other neurodegenerative disorders. N-Methylaspartate 29-33 neuroglobin Mus musculus 0-3