PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27068363-6	2016	Steady-state and time-resolved fluorescence spectroscopy reveal that binding of hesperidin to the active site of BACE1 induces a conformational transition of the protein from open to closed form.	Hesperidin	80-90	beta-secretase 1	Homo sapiens	113-118	
29932100-6	2018	Based on the biological evaluation, hesperidin demonstrated the best inhibitory properties toward BACE1, AChE, and BChE, with IC50 values of 10.02 +- 1.12, 22.80 +- 2.78, and 48.09 +- 0.74 µM, respectively.	Hesperidin	36-46	beta-secretase 1	Homo sapiens	98-103	
27068363-8	2016	Hesperidin is a high affinity BACE1 inhibitor and only 500 nM of the compound shows complete inhibition of the enzyme activity.	Hesperidin	0-10	beta-secretase 1	Homo sapiens	30-35