PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28242322-4	2017	The results demonstrated that most of the tested pyrethroids showed moderate to weak inhibitory effects against both CES1 and CES2, but deltamethrin displayed strong inhibition towards CES1.	decamethrin	136-148	carboxylesterase 1	Homo sapiens	185-189	
28242322-5	2017	The IC50 values of deltamethrin against CES1-mediated BMBT, DME, and DMCB hydrolysis were determined as 1.58muM, 2.39muM, and 3.3muM, respectively.	decamethrin	19-31	carboxylesterase 1	Homo sapiens	40-44	
28242322-6	2017	Moreover, deltamethrin was cell membrane permeable and capable of inhibition endogenous CES1 in living cells.	decamethrin	10-22	carboxylesterase 1	Homo sapiens	88-92	
28242322-7	2017	Further investigation revealed that deltamethrin inhibited CES1-mediated BMBT hydrolysis via competitive manner but noncompetitively inhibited DME or DMCB hydrolysis.	decamethrin	36-48	carboxylesterase 1	Homo sapiens	59-63	
28242322-8	2017	The inhibition behaviors of deltamethrin against CES1 were also studied by molecular docking simulation.	decamethrin	28-40	carboxylesterase 1	Homo sapiens	49-53	
28242322-9	2017	The results demonstrated that CES1 had at least two different ligand-binding sites, one was the DME site and another was the BMBT site which was identical to the binding site of deltamethrin.	decamethrin	178-190	carboxylesterase 1	Homo sapiens	30-34	
28242322-10	2017	In summary, deltamethrin was a strong reversible inhibitor against CES1 and it could tightly bind on CES1 at the same ligand-binding site as BMBT.	decamethrin	12-24	carboxylesterase 1	Homo sapiens	67-71	
28242322-10	2017	In summary, deltamethrin was a strong reversible inhibitor against CES1 and it could tightly bind on CES1 at the same ligand-binding site as BMBT.	decamethrin	12-24	carboxylesterase 1	Homo sapiens	101-105	
18983829-0	2009	Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin.	decamethrin	143-155	carboxylesterase 1	Homo sapiens	24-28	
16855054-9	2006	Results of CE metabolism revealed that human carboxylesterase 1 (hCE-1) was markedly more active toward deltamethrin than the class 1 rat CEs hydrolase A and B and the class 2 human CE (hCE-2); however, hydrolase A metabolized esfenvalerate 2-fold faster than hCE-1, whereas hydrolase B and hCE-1 hydrolyzed esfenvalerate at equal rates.	decamethrin	104-116	carboxylesterase 1	Homo sapiens	45-63	
16855054-9	2006	Results of CE metabolism revealed that human carboxylesterase 1 (hCE-1) was markedly more active toward deltamethrin than the class 1 rat CEs hydrolase A and B and the class 2 human CE (hCE-2); however, hydrolase A metabolized esfenvalerate 2-fold faster than hCE-1, whereas hydrolase B and hCE-1 hydrolyzed esfenvalerate at equal rates.	decamethrin	104-116	carboxylesterase 1	Homo sapiens	65-70