PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10926555-2 2000 We have shown previously that TNF-alpha upregulates the expression of Galpha(i-2) protein without significantly increasing G(s)alpha protein and enhances adenylyl cyclase inhibition by carbachol in cultured human airway smooth muscle cells (Hotta K, Emala CW, and Hirshman CA. Carbachol 185-194 tumor necrosis factor Homo sapiens 30-39 12202486-0 2002 Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-alpha. Carbachol 87-96 tumor necrosis factor Homo sapiens 131-163 12202486-8 2002 CCh caused the basolateral release of transforming growth factor alpha (TGF-alpha) into T(84) cell bathing media. Carbachol 0-3 tumor necrosis factor Homo sapiens 38-70 11245595-0 2001 PLD pathway involved in carbachol-induced Cl- secretion: possible role of TNF-alpha. Carbachol 24-33 tumor necrosis factor Homo sapiens 74-83 11245595-1 2001 In a previous study, it was found that exposure to tumor necrosis factor-alpha (TNF-alpha) potentiated the electrophysiological response to carbachol in a time-dependent and cycloheximide-sensitive manner. Carbachol 140-149 tumor necrosis factor Homo sapiens 51-78 11245595-1 2001 In a previous study, it was found that exposure to tumor necrosis factor-alpha (TNF-alpha) potentiated the electrophysiological response to carbachol in a time-dependent and cycloheximide-sensitive manner. Carbachol 140-149 tumor necrosis factor Homo sapiens 80-89 10800946-3 2000 The carbachol-induced arachidonate release is potentiated two- to threefold by pretreatment of A2058 cells with either of the inflammatory cytokines, tumor necrosis factor-alpha or interleukin-1beta . Carbachol 4-13 tumor necrosis factor Homo sapiens 150-177 10070103-5 1999 TNF-alpha treatment for 72 h significantly increased the expression of Galphai-2 and Gqalpha proteins and enhanced carbachol (10(-7) M)-mediated inhibition of adenylyl cyclase activity and inositol phosphate synthesis. Carbachol 115-124 tumor necrosis factor Homo sapiens 0-9 10712234-7 2000 However, the secretory response to the muscarinic receptor agonist carbachol was strongly increased after exposure to TNF-alpha. Carbachol 67-76 tumor necrosis factor Homo sapiens 118-127 10712234-8 2000 Application of the protein kinase C (PKC) inhibitor GF 109203X (bisindolylmaleimide I) inhibited the response to carbachol as well as the TNF-alpha-potentiated response, indicating that PKC mediates the effect of carbachol in this cell line. Carbachol 213-222 tumor necrosis factor Homo sapiens 138-147 9915989-2 1999 We previously demonstrated that TNF-alpha induces a small, delayed follicular stage-dependent increase in intracellular Ca2+ concentration ([Ca2+]i) in hen granulosa cells and promotes carbachol (Cch)-induced mobilization of Ca2+ from intracellular stores in cells otherwise unresponsive to the cytokine. Carbachol 185-194 tumor necrosis factor Homo sapiens 32-41 9915989-2 1999 We previously demonstrated that TNF-alpha induces a small, delayed follicular stage-dependent increase in intracellular Ca2+ concentration ([Ca2+]i) in hen granulosa cells and promotes carbachol (Cch)-induced mobilization of Ca2+ from intracellular stores in cells otherwise unresponsive to the cytokine. Carbachol 196-199 tumor necrosis factor Homo sapiens 32-41 8679222-3 1996 Pretreatment of human TSMC with TNF alpha potentiated cytosolic calcium [(Ca2+)i] transients evoked by carbachol. Carbachol 103-112 tumor necrosis factor Homo sapiens 32-41 8679222-4 1996 In a similar manner, selective TNF alpha-p55 receptor agonists such as htr-9, an activating monoclonal antibody, or a recombinant TNF-p55 (rTNF-p55), which specifically activates the TNF alpha-p55 receptor but not the TNF alpha-p75 receptor, also augmented [Ca2+]i transients evoked by carbachol. Carbachol 286-295 tumor necrosis factor Homo sapiens 31-40 8679222-4 1996 In a similar manner, selective TNF alpha-p55 receptor agonists such as htr-9, an activating monoclonal antibody, or a recombinant TNF-p55 (rTNF-p55), which specifically activates the TNF alpha-p55 receptor but not the TNF alpha-p75 receptor, also augmented [Ca2+]i transients evoked by carbachol. Carbachol 286-295 tumor necrosis factor Homo sapiens 183-192 8679222-4 1996 In a similar manner, selective TNF alpha-p55 receptor agonists such as htr-9, an activating monoclonal antibody, or a recombinant TNF-p55 (rTNF-p55), which specifically activates the TNF alpha-p55 receptor but not the TNF alpha-p75 receptor, also augmented [Ca2+]i transients evoked by carbachol. Carbachol 286-295 tumor necrosis factor Homo sapiens 183-192 7712026-1 1995 The effect of tumour necrosis factor-alpha (TNF alpha) on the increase in cytosolic free calcium ([Ca2+])i induced by carbachol and bradykinin (BK) was investigated in human tracheal smooth muscle cells in culture (TSMC). Carbachol 118-127 tumor necrosis factor Homo sapiens 44-53 7578678-1 1995 In the present study, we have determined the influence of tumor necrosis factor alpha (TNF alpha) on both basal and carbamylcholine chloride (Cch)-induced [Ca2+]i in granulosa cells from the largest (F1) and smallest (F5,6) preovulatory follicles. Carbachol 116-140 tumor necrosis factor Homo sapiens 58-85 7578678-1 1995 In the present study, we have determined the influence of tumor necrosis factor alpha (TNF alpha) on both basal and carbamylcholine chloride (Cch)-induced [Ca2+]i in granulosa cells from the largest (F1) and smallest (F5,6) preovulatory follicles. Carbachol 116-140 tumor necrosis factor Homo sapiens 87-96 7578678-1 1995 In the present study, we have determined the influence of tumor necrosis factor alpha (TNF alpha) on both basal and carbamylcholine chloride (Cch)-induced [Ca2+]i in granulosa cells from the largest (F1) and smallest (F5,6) preovulatory follicles. Carbachol 142-145 tumor necrosis factor Homo sapiens 58-85 7578678-1 1995 In the present study, we have determined the influence of tumor necrosis factor alpha (TNF alpha) on both basal and carbamylcholine chloride (Cch)-induced [Ca2+]i in granulosa cells from the largest (F1) and smallest (F5,6) preovulatory follicles. Carbachol 142-145 tumor necrosis factor Homo sapiens 87-96 7578678-6 1995 Pretreatment with TNF alpha (4-5 min) increased the magnitude of the Cch response in both F1 and F5,6 granulosa cells previously incapable of producing large Cch-induced changes in [Ca2+]i. Carbachol 69-72 tumor necrosis factor Homo sapiens 18-27 7578678-6 1995 Pretreatment with TNF alpha (4-5 min) increased the magnitude of the Cch response in both F1 and F5,6 granulosa cells previously incapable of producing large Cch-induced changes in [Ca2+]i. Carbachol 158-161 tumor necrosis factor Homo sapiens 18-27 7578678-7 1995 In F1 cells, the effects of TNF alpha on Cch-induced [Ca2+]i were far more extensive, such that the Cch response in the presence of TNF alpha was indistinguishable from the fast Cch-induced Ca2+ transient reported previously. Carbachol 41-44 tumor necrosis factor Homo sapiens 28-37 7578678-7 1995 In F1 cells, the effects of TNF alpha on Cch-induced [Ca2+]i were far more extensive, such that the Cch response in the presence of TNF alpha was indistinguishable from the fast Cch-induced Ca2+ transient reported previously. Carbachol 41-44 tumor necrosis factor Homo sapiens 132-141 7578678-7 1995 In F1 cells, the effects of TNF alpha on Cch-induced [Ca2+]i were far more extensive, such that the Cch response in the presence of TNF alpha was indistinguishable from the fast Cch-induced Ca2+ transient reported previously. Carbachol 100-103 tumor necrosis factor Homo sapiens 28-37 7578678-7 1995 In F1 cells, the effects of TNF alpha on Cch-induced [Ca2+]i were far more extensive, such that the Cch response in the presence of TNF alpha was indistinguishable from the fast Cch-induced Ca2+ transient reported previously. Carbachol 100-103 tumor necrosis factor Homo sapiens 132-141 7578678-7 1995 In F1 cells, the effects of TNF alpha on Cch-induced [Ca2+]i were far more extensive, such that the Cch response in the presence of TNF alpha was indistinguishable from the fast Cch-induced Ca2+ transient reported previously. Carbachol 100-103 tumor necrosis factor Homo sapiens 28-37 7578678-7 1995 In F1 cells, the effects of TNF alpha on Cch-induced [Ca2+]i were far more extensive, such that the Cch response in the presence of TNF alpha was indistinguishable from the fast Cch-induced Ca2+ transient reported previously. Carbachol 100-103 tumor necrosis factor Homo sapiens 132-141 7578678-8 1995 Furthermore, the TNF alpha effect was reversible, as subsequent challenge with Cch in the absence of TNF alpha failed to produce the large Ca(2+)-transients observed earlier with the cytokine present. Carbachol 79-82 tumor necrosis factor Homo sapiens 17-26 7578678-10 1995 In addition, TNF alpha appeared to enhance Cch-induced mobilization of Ca2+ from intracellular stores. Carbachol 43-46 tumor necrosis factor Homo sapiens 13-22 8779914-9 1996 Serum-, carbachol-, and thapsigargin-stimulated [Ca2+]i elevations were reduced by 90, 60, and > 65%, respectively, in cells treated with IFN-gamma +/- TNF-alpha and 30, 45, and 45%, respectively, in cells treated with TNF-alpha. Carbachol 8-17 tumor necrosis factor Homo sapiens 155-164 8779914-9 1996 Serum-, carbachol-, and thapsigargin-stimulated [Ca2+]i elevations were reduced by 90, 60, and > 65%, respectively, in cells treated with IFN-gamma +/- TNF-alpha and 30, 45, and 45%, respectively, in cells treated with TNF-alpha. Carbachol 8-17 tumor necrosis factor Homo sapiens 222-231 19542247-10 2009 In separate experiments, incubation of PCLS with IL-13 or TNFalpha (100 ng/ml) increased airway sensitivity to carbachol. Carbachol 111-120 tumor necrosis factor Homo sapiens 58-66 18514752-4 2008 In cultured human ASM cells, where CD38 has been involved in TNFalpha-induced enhanced calcium signals to carbachol and bradykinin, we found that neutralizing anti-IFNbeta prevented TNFalpha enhancing action only on carbachol responses but not to that induced by bradykinin. Carbachol 106-115 tumor necrosis factor Homo sapiens 61-69 18514752-4 2008 In cultured human ASM cells, where CD38 has been involved in TNFalpha-induced enhanced calcium signals to carbachol and bradykinin, we found that neutralizing anti-IFNbeta prevented TNFalpha enhancing action only on carbachol responses but not to that induced by bradykinin. Carbachol 106-115 tumor necrosis factor Homo sapiens 182-190 18514752-4 2008 In cultured human ASM cells, where CD38 has been involved in TNFalpha-induced enhanced calcium signals to carbachol and bradykinin, we found that neutralizing anti-IFNbeta prevented TNFalpha enhancing action only on carbachol responses but not to that induced by bradykinin. Carbachol 216-225 tumor necrosis factor Homo sapiens 61-69 18514752-4 2008 In cultured human ASM cells, where CD38 has been involved in TNFalpha-induced enhanced calcium signals to carbachol and bradykinin, we found that neutralizing anti-IFNbeta prevented TNFalpha enhancing action only on carbachol responses but not to that induced by bradykinin. Carbachol 216-225 tumor necrosis factor Homo sapiens 182-190