PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10971280-7 2000 RESULTS: The potency of AII was similar in child and adult detrusor strips, with mean (SEM) pD2 values of 6.9 (1.0) (n = 25) and 6.7 (0.2) (n = 9) respectively, and the maximum responses (to 10 micromol/L AII) rather low (39% and 49%, respectively, P > 0.05), compared with carbachol (100 micromol/L). Carbachol 277-286 NLR family pyrin domain containing 3 Homo sapiens 24-27 34415562-10 2022 RESULTS: We found that carbachol increased the expression of NLRP3 inflammasome (NLRP3, ASC, cleaved caspase-1, IL-1beta, and IL-18). Carbachol 23-32 NLR family pyrin domain containing 3 Homo sapiens 61-66 34415562-10 2022 RESULTS: We found that carbachol increased the expression of NLRP3 inflammasome (NLRP3, ASC, cleaved caspase-1, IL-1beta, and IL-18). Carbachol 23-32 NLR family pyrin domain containing 3 Homo sapiens 81-86 34415562-13 2022 The addition of RA also significantly reduced the effect of carbachol on NLRP3 inflammasomes. Carbachol 60-69 NLR family pyrin domain containing 3 Homo sapiens 73-78 34415562-14 2022 CONCLUSIONS: Our current study suggests that carbachol induces NLRP3 inflammasome activation through mAChR and NF-kB, and that RA abolishes the inflammatory response. Carbachol 45-54 NLR family pyrin domain containing 3 Homo sapiens 63-68