PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31026007-6	2019	In an MCF10DCIS.com xenograft animal model, beta-thujaplicin significantly inhibited tumor growth, reduced tumor weight, and regulated the expression of cell cycle proteins, phosphorylation of AKT and GSK-3beta, and protein level of beta-catenin in the tumor tissues.	beta-thujaplicin	44-60	AKT serine/threonine kinase 1	Homo sapiens	193-196	
30874538-5	2019	Further using beta-Thujaplicin combined with an autophagy blocker or agonist treatment HepG2 cells, we found that beta-Thujaplicin induced autophagic cell death (ACD) mediated by ROS caused inhibition of the Akt-mTOR signaling pathway.	beta-thujaplicin	114-130	AKT serine/threonine kinase 1	Homo sapiens	208-211	
24433214-8	2014	Hinokitiol also specifically inhibited the convulxin-mediated activation of protein kinase C, phospholipase Cgamma2, Akt, mitogen-activated protein kinases, and Lyn.	beta-thujaplicin	0-10	AKT serine/threonine kinase 1	Homo sapiens	117-120	
35399709-8	2022	The transfection of cells with active P-AKT rescued hinokitiol-induced downregulation of P-gp, suggesting the involvement of Akt/mTOR/p70s6K signaling in P-gp expression.	beta-thujaplicin	52-62	AKT serine/threonine kinase 1	Homo sapiens	125-128	
23473801-6	2013	Hinokitiol inhibited the phosphorylation of phospholipase C (PLC)gamma2, protein kinase C (PKC), mitogen-activated protein kinases (MAPKs), and Akt in collagen-activated human platelets, and significantly reduced intracellular calcium mobilization and hydroxyl radical (OH ) formation.	beta-thujaplicin	0-10	AKT serine/threonine kinase 1	Homo sapiens	144-147	
23473801-10	2013	In conclusion, hinokitiol may inhibit platelet activation by inhibiting the PLCgamma2-PKC cascade and hydroxyl radical formation, followed by suppressing the activation of MAPKs and Akt.	beta-thujaplicin	15-25	AKT serine/threonine kinase 1	Homo sapiens	182-185