PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34361036-0	2021	Hinokitiol Exhibits Antitumor Properties through Induction of ROS-Mediated Apoptosis and p53-Driven Cell-Cycle Arrest in Endometrial Cancer Cell Lines (Ishikawa, HEC-1A, KLE).	beta-thujaplicin	0-10	tumor protein p53	Homo sapiens	89-92	
34361036-5	2021	Hinokitiol significantly suppressed cell proliferation through the inhibition of the expression of cell-cycle mediators, such as cyclin D1 and cyclin-dependent kinase 4 (CDK4), as well as the induction of the tumor suppressor protein p53.	beta-thujaplicin	0-10	tumor protein p53	Homo sapiens	234-237	
35163553-6	2022	In U-2 OS cells with wild-type tumor suppressor p53, we found that hinokitiol exposure induced p53 expression and cellular senescence, and knockdown of p53 suppressed the senescence.	beta-thujaplicin	67-77	tumor protein p53	Homo sapiens	48-51	
35163553-6	2022	In U-2 OS cells with wild-type tumor suppressor p53, we found that hinokitiol exposure induced p53 expression and cellular senescence, and knockdown of p53 suppressed the senescence.	beta-thujaplicin	67-77	tumor protein p53	Homo sapiens	95-98	
35163553-7	2022	However, in MG-63 cells with mutated p53, a high percentage of cells underwent apoptosis with cleaved-PARP expression and Annexin V staining after hinokitiol treatment.	beta-thujaplicin	147-157	tumor protein p53	Homo sapiens	37-40	
35163553-9	2022	As the autophagy was suppressed through the autophagy inhibitor chloroquine, hinokitiol-induced senescence in U-2 OS cells was significantly enhanced accompanying more abundant p53 expression.	beta-thujaplicin	77-87	tumor protein p53	Homo sapiens	177-180	
32917321-9	2020	Western blot analysis further demonstrated that hinokitiol treatment increased the levels of p53 and p21, and concomitantly reduced the expression of cell cycle regulatory proteins, including cyclin D and cyclin E. SA-beta-gal assay showed that hinokitiol treatment significantly induced beta-galactosidase activity.	beta-thujaplicin	48-58	tumor protein p53	Homo sapiens	93-96	
29565268-11	2018	These observations indicate that hinokitiol inhibited the migration of lung cancer A549 cells through several mechanisms, including the activation of caspases-9 and -3, induction of p53/Bax and antioxidant CAT and SOD, and reduction of MMP-2 and -9 activities.	beta-thujaplicin	33-43	tumor protein p53	Homo sapiens	182-185