PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22998419-0	2012	Conformational restriction approach to beta-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode.	cyclopropane	86-98	beta-secretase 1	Homo sapiens	55-60	
22998419-2	2012	We applied this approach to BACE1 inhibitors and designed four stereoisomeric cyclopropane compounds in which the ethylene linker of a known amidine-type inhibitor 2 was replaced with chiral cyclopropane rings.	cyclopropane	191-203	beta-secretase 1	Homo sapiens	28-33	
22998419-4	2012	X-ray structure analysis of the complex of 6 and BACE1 revealed that its unique binding mode is due to the apparent CH-pi interaction between the rigid cyclopropane ring and the Tyr71 side chain.	cyclopropane	152-164	beta-secretase 1	Homo sapiens	49-54