PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24867403-4 2015 Optimization of this new cyclopropane-linked series was based on a computational model of a PLK4 X-ray structure and SAR attained from the analogous alkenelinked series. cyclopropane 25-37 sarcosine dehydrogenase Homo sapiens 117-120 15080983-2 2004 SAR studies of this series resulted in the discovery of potent and selective antagonists 7b and 7n bearing a 4-(2,4,6-trisubstituted-phenyl) ring and a bulky 2-(N-bis(cyclopropane)methyl-N-propyl)amino group. cyclopropane 166-179 sarcosine dehydrogenase Homo sapiens 0-3