PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9011569-3 1997 The results of reporter gene analyses revealed that the insulin gene promoter is more sensitive to glycation than the control beta-actin gene promoter; approximately 50 and 80% of the insulin gene promoter activity was lost when the cells were kept for 3 d in the presence of 40 and 60 mM D-ribose, respectively. Ribose 289-297 insulin Homo sapiens 56-63 3529502-5 1986 Among monosaccharides, 2-deoxy-D-ribose, D-galactosamine, L-fucose, N-acetylneuraminic acid and D-ribose decreased insulin release and had no effect on insulin release by D-glucose. Ribose 31-39 insulin Homo sapiens 115-122 1901925-0 1991 Serum levels of glucose, insulin, and C-peptide during long-term D-ribose administration in man. Ribose 65-73 insulin Homo sapiens 38-47 30715843-6 2019 In this study, four physiologically relevant monosaccharides, methylglyoxal, glucose, fructose, and ribose were used to glycate human insulin and two C-terminus truncated insulin analogues. Ribose 100-106 insulin Homo sapiens 134-141 30715843-6 2019 In this study, four physiologically relevant monosaccharides, methylglyoxal, glucose, fructose, and ribose were used to glycate human insulin and two C-terminus truncated insulin analogues. Ribose 100-106 insulin Homo sapiens 171-178 26519138-0 2016 D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts. Ribose 0-8 insulin Homo sapiens 22-29 12218186-6 2002 These results demonstrate that glucose and ribose increase islet peroxide accumulation and that the adverse consequences of ribose-induced oxidative stress on insulin mRNA, content, and secretion can be augmented by a glutathione synthesis inhibitor and prevented by increasing islet GPx activity. Ribose 124-130 insulin Homo sapiens 159-166 26350612-4 2015 METHODS: oxPTM of insulin was generated using ribose and various reactive oxygen species. Ribose 46-52 insulin Homo sapiens 18-25