PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33921149-2	2021	Previous metabolomic studies showed a positive association of diabetes and insulin resistance with branched-chain amino acids (AAs) and aromatic AAs.	Amino Acids	127-130	insulin	Homo sapiens	75-82	
12765947-5	2003	Insulin reduced muscle release of AAs mainly by inhibition of protein breakdown.	Amino Acids	34-37	insulin	Homo sapiens	0-7	
12068492-0	2002	[The prolonged action of an insulin peptidomimetic by the substitution of L-amino acid for its D-isomer].	Amino Acids	74-86	insulin	Homo sapiens	28-35	
34222079-1	2021	Background: Amino acids (AAs) and acylcarnitines play a key role in metabolic disease and can be used as biomarkers of various diseases such as malignancies, type 2 diabetes (T2D), insulin resistance, and cardiovascular diseases, therefore, designing an accurate and simple laboratory method that simultaneously measure both groups of substances, could improve the process of analytes quantification.	Amino Acids	25-28	insulin	Homo sapiens	181-188	
2673694-7	1989	Glucagon, alpha-amino acid nitrogen, and lactate concentrations were exquisitely sensitive to a rise in glucose and insulin concentrations.	Amino Acids	10-26	insulin	Homo sapiens	116-123	
33096658-1	2020	Different amino acids (AAs) may exert distinct effects on postprandial glucose and insulin concentrations.	Amino Acids	23-26	insulin	Homo sapiens	83-90	
31539818-2	2020	During cardiac surgery, the administration of high-dose insulin along with dextrose titration maintains normoglycemia, but dramatically decreases plasma amino acids (AAs) compared with preoperative fasting levels.	Amino Acids	166-169	insulin	Homo sapiens	56-63	
31539818-4	2020	We investigated whether parenteral infusion of AAs during and immediately after cardiac surgery would prevent hypoaminoacidemia in patients who receive high-dose insulin therapy.	Amino Acids	47-50	insulin	Homo sapiens	162-169	
31729529-0	2019	Cajanonic acid A regulates the ratio of Th17/Treg via inhibition of expression of IL-6 and TGF-beta in insulin-resistant HepG2 cells.	Amino Acids	0-16	insulin	Homo sapiens	103-110	
31729529-1	2019	BACKGROUND: The objectives of this study are to investigate whether cajanonic acid A (CAA) can reduce insulin resistance in HepG2 cells and to gain a preliminary understanding of the mechanisms underlying this effect.	Amino Acids	68-84	insulin	Homo sapiens	102-109	
18514621-4	2008	We also report preliminary experimental data that suggest the existence of intracellular alternatives to insulin metabolic pathways stimulated by nutrients such as amino acids (AAs).	Amino Acids	177-180	insulin	Homo sapiens	105-112	
29601913-9	2018	CONCLUSIONS: The increase in fasting serum AAs can be an early manifestation of insulin resistance.	Amino Acids	43-46	insulin	Homo sapiens	80-87	
28802074-1	2018	Plasma concentrations of amino acids (AAs), in particular, branched chain AAs (BCAAs), are often found increased in nonalcoholic fatty liver disease (NAFLD); however, if this is due to increased muscular protein catabolism, obesity, and/or increased insulin resistance (IR) or impaired tissue metabolism is unknown.	Amino Acids	38-41	insulin	Homo sapiens	250-257	
30885989-1	2019	Several amino acids (AAs) have been shown to be associated with insulin resistance and increased risk of type 2 diabetes, but no previous studies have investigated the association of AAs with insulin secretion in a longitudinal setting.	Amino Acids	21-24	insulin	Homo sapiens	64-71	
30604098-3	2019	The functionality of this conserved Gly residue in the insulin family has been studied by replacing it with natural L-amino acids or the corresponding unnatural D-amino acids.	Amino Acids	116-129	insulin	Homo sapiens	55-62	
21616512-2	2011	The purpose of this study was to examine the effect of high-dose insulin therapy on the plasma concentrations of amino acids (AAs) in patients undergoing coronary artery bypass grafting surgery.	Amino Acids	126-129	insulin	Homo sapiens	65-72	
18514621-5	2008	Indeed, we found that oral supplements with AAs stimulated both glucose transporter-4 and protein synthesis through independent insulin signals in rat hearts.	Amino Acids	44-47	insulin	Homo sapiens	128-135