PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2830631-6	1987	When added to CPZ--pretreated 32P prelabelled platelets, thrombin decreased the radio-activity in PIP2, PIP, and PA to 4, 86, and 10% of the control, respectively.	phosphatidylinositol 4-phosphate	98-101	coagulation factor II, thrombin	Homo sapiens	57-65	
18503745-1	2008	Incubation of platelets with increasing concentrations of thrombin produced large amounts of phosphatidic acid (PA) and distinct changes in phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2), prominent metabolites in the polyphosphoinositide (PPI) cycle.	phosphatidylinositol 4-phosphate	140-172	coagulation factor II, thrombin	Homo sapiens	58-66	
2174010-5	1990	Hydrolysis of PIP2, PIP, and PI; accumulation of PA; and phosphorylation of P20 in platelets stimulated by 0.05 U/ml thrombin were significantly increased in the DM-A group compared with the control or DM-B group.	phosphatidylinositol 4-phosphate	14-17	coagulation factor II, thrombin	Homo sapiens	117-125	
2548908-10	1989	There was significantly decreased [32P]PIP2 and [32P]PIP hydrolysis and decreased [32P]PA formation in IDDM after platelet stimulation with 4 U/ml human thrombin.	phosphatidylinositol 4-phosphate	39-42	coagulation factor II, thrombin	Homo sapiens	153-161	
2845924-5	1988	The thrombin-induced hydrolysis of inositol phospholipids by phospholipase C, which was measured as the formation of [32P]PA, was potentiated by adrenaline, as was the increase in the levels of [32P]PIP2 and [32P]PIP.	phosphatidylinositol 4-phosphate	199-202	coagulation factor II, thrombin	Homo sapiens	4-12	
2822018-2	1987	In membranes prepared from WI-38 human lung fibroblasts, thrombin activated an inositol-lipid-specific PLC that hydrolysed [32P]PIP2 and [32P]phosphatidylinositol 4-monophosphate (PIP) to [32P]IP3 and [32P]inositol 1,4-bisphosphate (IP2) respectively.	phosphatidylinositol 4-phosphate	142-178	coagulation factor II, thrombin	Homo sapiens	57-65	
11008120-6	2000	In contrast to the relatively small changes in PI and PIP(2), the levels of labeled PIP, precursor to PIP(2), increased 2- to 4-fold in both resting and thrombin-treated platelets from 5 microM up to about 50-100 microM of drugs and remained elevated throughout the permeabilization concentrations.	phosphatidylinositol 4-phosphate	84-87	coagulation factor II, thrombin	Homo sapiens	153-161	
11008120-6	2000	In contrast to the relatively small changes in PI and PIP(2), the levels of labeled PIP, precursor to PIP(2), increased 2- to 4-fold in both resting and thrombin-treated platelets from 5 microM up to about 50-100 microM of drugs and remained elevated throughout the permeabilization concentrations.	phosphatidylinositol 4-phosphate	84-87	coagulation factor II, thrombin	Homo sapiens	153-161	
11008120-9	2000	[(32)P]PIP(2) levels increased about 25% in response to thrombin treatment alone; low concentrations of drugs led to another 25% elevation.	phosphatidylinositol 4-phosphate	7-10	coagulation factor II, thrombin	Homo sapiens	56-64	
8396627-6	1993	Thrombin-stimulated decreases in PIP2 and PIP, found in the presence of U73122, could be explained by the action of phospholipase C in the absence of resynthesis.	phosphatidylinositol 4-phosphate	33-36	coagulation factor II, thrombin	Homo sapiens	0-8	
3026339-3	1986	At non-lytic concentrations, chlorpromazine caused a dramatic increase in the thrombin- or phorbol ester-mediated incorporation of 32P into phosphatidylinositol 4-phosphate and, to a lesser extent, into phosphatidylinositol 4,5-bisphosphate in platelets pulse-labelled with [32P]Pi.	phosphatidylinositol 4-phosphate	140-172	coagulation factor II, thrombin	Homo sapiens	78-86	
2999166-2	1985	Thrombin and EGF stimulated comparable increases in the synthesis (30-50%) and degradation (20-40%) of phosphatidylinositol 4-monophosphate (DPI) and phosphatidylinositol 4,5-bisphosphate (TPI) in a cell line which is mitogenically responsive to both growth factors.	phosphatidylinositol 4-phosphate	103-139	coagulation factor II, thrombin	Homo sapiens	0-8	
6301436-2	1983	The addition of thrombin to [3H]glycerol-labeled platelets induced an initial loss and a subsequent increase of the radioactivity in phosphatidylinositol-4,5-bisphosphate (TPI) without any significant change in phosphatidylinositol-4-phosphate (DPI).	phosphatidylinositol 4-phosphate	211-243	coagulation factor II, thrombin	Homo sapiens	16-24	
3024627-7	1986	The only observed effect of Li+ on phosphoinositide metabolism was a thrombin-induced decrease (P less than 0.05) in labelled phosphatidylinositol 4-phosphate in Li+-treated platelets; this suggests an effect on phospholipase C. Li+ enhanced (P less than 0.05) the thrombin-induced increase in labelled lysophosphatidylinositol, suggesting an effect on phospholipase A2.	phosphatidylinositol 4-phosphate	126-158	coagulation factor II, thrombin	Homo sapiens	69-77