PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33461946-3 2021 One prominent function mediated by VAPB at these sites is lipid exchange, and a recurrent phenotype observed in all models investigating knockout or knockdown of VAPs is a significant increase in the levels of phosphatidylinositol-4-phosphate (PI4P). phosphatidylinositol 4-phosphate 210-242 VAMP associated protein B and C Homo sapiens 35-39 30745341-5 2019 Nonetheless, cells with even partially depleted VAPB showed an increase in Golgi- and acidic vesicle-localized phosphatidylinositol-4-phosphate (PI4P) and reduced neurite extension when induced to differentiate. phosphatidylinositol 4-phosphate 111-143 VAMP associated protein B and C Homo sapiens 48-52 30745341-5 2019 Nonetheless, cells with even partially depleted VAPB showed an increase in Golgi- and acidic vesicle-localized phosphatidylinositol-4-phosphate (PI4P) and reduced neurite extension when induced to differentiate. phosphatidylinositol 4-phosphate 145-149 VAMP associated protein B and C Homo sapiens 48-52 26812496-5 2016 Knockdown of ORP3 or VAPB increased the intracellular level of phosphatidylinositol 4-phosphate (PtdIns4P). phosphatidylinositol 4-phosphate 63-95 VAMP associated protein B and C Homo sapiens 21-25 26812496-5 2016 Knockdown of ORP3 or VAPB increased the intracellular level of phosphatidylinositol 4-phosphate (PtdIns4P). phosphatidylinositol 4-phosphate 97-105 VAMP associated protein B and C Homo sapiens 21-25 26812496-6 2016 Decreasing PtdIns4P levels by inhibiting its synthesis reduced the severity of the mutant VAPB-induced membrane expansions and restored Emerin trafficking to the NE. phosphatidylinositol 4-phosphate 11-19 VAMP associated protein B and C Homo sapiens 90-94 26812496-7 2016 Thus, VAPB and its interacting partners cooperatively regulate protein trafficking through the ERGIC by modulating PtdIns4P levels. phosphatidylinositol 4-phosphate 115-123 VAMP associated protein B and C Homo sapiens 6-10 28912432-7 2017 This supports the loss of VAPB function in ALS8 pathogenesis and suggests that reducing intracellular PtdIns4P might be an effective therapeutic strategy in delaying progressive loss of motor neurons. phosphatidylinositol 4-phosphate 102-110 VAMP associated protein B and C Homo sapiens 26-30 28912432-7 2017 This supports the loss of VAPB function in ALS8 pathogenesis and suggests that reducing intracellular PtdIns4P might be an effective therapeutic strategy in delaying progressive loss of motor neurons. phosphatidylinositol 4-phosphate 102-110 VAMP associated protein B and C Homo sapiens 43-47