PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29142407-0 2017 Molecular Docking Analysis of Phytic Acid and 4-hydroxyisoleucine as Cyclooxygenase-2, Microsomal Prostaglandin E Synthase-2, Tyrosinase, Human Neutrophil Elastase, Matrix Metalloproteinase-2 and -9, Xanthine Oxidase, Squalene Synthase, Nitric Oxide Synthase, Human Aldose Reductase, and Lipoxygenase Inhibitors. Phytic Acid 30-41 aldo-keto reductase family 1 member B Homo sapiens 266-282 12846414-3 2003 In this study, we investigated the in vitro growth inhibitory activity of IP6 in combination with adriamycin or tamoxifen, against three human breast cancer cell lines: estrogen receptor (ER) alpha-positive MCF-7, ER alpha-negative MDA-MB 231 and adriamycin-resistant MCF-7 (MCF-7/Adr) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Phytic Acid 74-77 aldo-keto reductase family 1 member B Homo sapiens 275-284 12846414-4 2003 Much lower concentrations of IP6 were required after 96 h of treatment to inhibit the growth of MCF-7/Adr cells than MCF-7 cells; the IC50 for MCF-7/Adr cells was 1.26 mM compared to 4.18 mM for MCF-7 cells. Phytic Acid 29-32 aldo-keto reductase family 1 member B Homo sapiens 96-105 12846414-4 2003 Much lower concentrations of IP6 were required after 96 h of treatment to inhibit the growth of MCF-7/Adr cells than MCF-7 cells; the IC50 for MCF-7/Adr cells was 1.26 mM compared to 4.18 mM for MCF-7 cells. Phytic Acid 29-32 aldo-keto reductase family 1 member B Homo sapiens 143-152 12846414-8 2003 Synergism was also observed when IP6 was administered after tamoxifen in all three cell lines studied (CI = 0.343, 0.701 and 0.819; p < 0.0001, p = 0.0003 and 0.0241 for MCF-7/Adr, MCF-7 and MDA-MB 231, respectively). Phytic Acid 33-36 aldo-keto reductase family 1 member B Homo sapiens 173-189