PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15626777-8 2005 Removal of iron from asbestos by desferrioxamine B or phytic acid inhibited asbestos-induced decreases in EGFR phosphorylation. Phytic Acid 54-65 epidermal growth factor receptor Homo sapiens 106-110 19544333-8 2010 Together, these findings for the first time establish IP6 efficacy in inhibiting aberrant EGF receptor (EGFR) or IGF-1 receptor (IGF-1R) pathway-mediated sustained growth promoting and survival signaling cascades in advanced and androgen-independent human PCa PC-3 cells, which might have translational implications in advanced human PCa control and management. Phytic Acid 54-57 epidermal growth factor receptor Homo sapiens 90-102 19544333-8 2010 Together, these findings for the first time establish IP6 efficacy in inhibiting aberrant EGF receptor (EGFR) or IGF-1 receptor (IGF-1R) pathway-mediated sustained growth promoting and survival signaling cascades in advanced and androgen-independent human PCa PC-3 cells, which might have translational implications in advanced human PCa control and management. Phytic Acid 54-57 epidermal growth factor receptor Homo sapiens 104-108 11133812-0 2000 Impairment of erbB1 receptor and fluid-phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU145 cells. Phytic Acid 95-117 epidermal growth factor receptor Homo sapiens 14-19 11133812-4 2000 As these are essential components of receptor-mediated and fluid-phase endocytosis, respectively, we reasoned that IP6 might impair erbB1 endocytosis and associated signaling in human PCA cells, leading to their growth inhibition. Phytic Acid 115-118 epidermal growth factor receptor Homo sapiens 132-137 11133812-5 2000 IP6 strongly to completely inhibited (26-100%; P < 0.05) transforming growth factor alpha-induced binding of activated erbB1 to AP2 in human PCA DU145 cells, demonstrating the impairment of the initial step in ligand-induced erbB1 endocytosis. Phytic Acid 0-3 epidermal growth factor receptor Homo sapiens 122-127 11133812-5 2000 IP6 strongly to completely inhibited (26-100%; P < 0.05) transforming growth factor alpha-induced binding of activated erbB1 to AP2 in human PCA DU145 cells, demonstrating the impairment of the initial step in ligand-induced erbB1 endocytosis. Phytic Acid 0-3 epidermal growth factor receptor Homo sapiens 228-233 11133812-9 2000 These effects of IP6, however, were associated with strong inhibition of ligand-induced Shc phosphorylation (77-84% decrease; P < 0.05) and its binding to erbB1 (58-100% decrease; P < 0.05). Phytic Acid 17-20 epidermal growth factor receptor Homo sapiens 158-163 11133812-12 2000 The inhibition of erbB1 receptor and fluid-phase endocytosis, and associated signaling by IP6, was corroborated by very strong to complete inhibition (70-100%; P < 0.05) of extracellular signal-regulated protein kinase 1/2 activation by IP6. Phytic Acid 90-93 epidermal growth factor receptor Homo sapiens 18-23 11133812-12 2000 The inhibition of erbB1 receptor and fluid-phase endocytosis, and associated signaling by IP6, was corroborated by very strong to complete inhibition (70-100%; P < 0.05) of extracellular signal-regulated protein kinase 1/2 activation by IP6. Phytic Acid 240-243 epidermal growth factor receptor Homo sapiens 18-23 11133812-14 2000 Targeting the impairment of erbB1 endocytosis and associated mitogenic signaling by IP6 in advanced and androgen-independent human PCA DU145 cells could be a useful approach for treating PCA. Phytic Acid 84-87 epidermal growth factor receptor Homo sapiens 28-33