PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15626777-8	2005	Removal of iron from asbestos by desferrioxamine B or phytic acid inhibited asbestos-induced decreases in EGFR phosphorylation.	Phytic Acid	54-65	epidermal growth factor receptor	Homo sapiens	106-110	
19544333-8	2010	Together, these findings for the first time establish IP6 efficacy in inhibiting aberrant EGF receptor (EGFR) or IGF-1 receptor (IGF-1R) pathway-mediated sustained growth promoting and survival signaling cascades in advanced and androgen-independent human PCa PC-3 cells, which might have translational implications in advanced human PCa control and management.	Phytic Acid	54-57	epidermal growth factor receptor	Homo sapiens	90-102	
19544333-8	2010	Together, these findings for the first time establish IP6 efficacy in inhibiting aberrant EGF receptor (EGFR) or IGF-1 receptor (IGF-1R) pathway-mediated sustained growth promoting and survival signaling cascades in advanced and androgen-independent human PCa PC-3 cells, which might have translational implications in advanced human PCa control and management.	Phytic Acid	54-57	epidermal growth factor receptor	Homo sapiens	104-108	
11133812-0	2000	Impairment of erbB1 receptor and fluid-phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU145 cells.	Phytic Acid	95-117	epidermal growth factor receptor	Homo sapiens	14-19	
11133812-4	2000	As these are essential components of receptor-mediated and fluid-phase endocytosis, respectively, we reasoned that IP6 might impair erbB1 endocytosis and associated signaling in human PCA cells, leading to their growth inhibition.	Phytic Acid	115-118	epidermal growth factor receptor	Homo sapiens	132-137	
11133812-5	2000	IP6 strongly to completely inhibited (26-100%; P < 0.05) transforming growth factor alpha-induced binding of activated erbB1 to AP2 in human PCA DU145 cells, demonstrating the impairment of the initial step in ligand-induced erbB1 endocytosis.	Phytic Acid	0-3	epidermal growth factor receptor	Homo sapiens	122-127	
11133812-5	2000	IP6 strongly to completely inhibited (26-100%; P < 0.05) transforming growth factor alpha-induced binding of activated erbB1 to AP2 in human PCA DU145 cells, demonstrating the impairment of the initial step in ligand-induced erbB1 endocytosis.	Phytic Acid	0-3	epidermal growth factor receptor	Homo sapiens	228-233	
11133812-9	2000	These effects of IP6, however, were associated with strong inhibition of ligand-induced Shc phosphorylation (77-84% decrease; P < 0.05) and its binding to erbB1 (58-100% decrease; P < 0.05).	Phytic Acid	17-20	epidermal growth factor receptor	Homo sapiens	158-163	
11133812-12	2000	The inhibition of erbB1 receptor and fluid-phase endocytosis, and associated signaling by IP6, was corroborated by very strong to complete inhibition (70-100%; P < 0.05) of extracellular signal-regulated protein kinase 1/2 activation by IP6.	Phytic Acid	90-93	epidermal growth factor receptor	Homo sapiens	18-23	
11133812-12	2000	The inhibition of erbB1 receptor and fluid-phase endocytosis, and associated signaling by IP6, was corroborated by very strong to complete inhibition (70-100%; P < 0.05) of extracellular signal-regulated protein kinase 1/2 activation by IP6.	Phytic Acid	240-243	epidermal growth factor receptor	Homo sapiens	18-23	
11133812-14	2000	Targeting the impairment of erbB1 endocytosis and associated mitogenic signaling by IP6 in advanced and androgen-independent human PCA DU145 cells could be a useful approach for treating PCA.	Phytic Acid	84-87	epidermal growth factor receptor	Homo sapiens	28-33