PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23285690-5 2012 The aim of this study was to examine effect of IP6 on human p38alpha MAP kinase activity and the expression of gene encoding p38 MAP kinase in unstimulated and IL-1beta-stimulated Caco-2 cells. Phytic Acid 47-50 mitogen-activated protein kinase 14 Homo sapiens 60-68 23285690-5 2012 The aim of this study was to examine effect of IP6 on human p38alpha MAP kinase activity and the expression of gene encoding p38 MAP kinase in unstimulated and IL-1beta-stimulated Caco-2 cells. Phytic Acid 47-50 mitogen-activated protein kinase 14 Homo sapiens 60-63 23285690-6 2012 Furthermore, the role of signaling pathways involving p38 MAP kinase in IP6-induced down-regulation of IL-8 secretion by unstimulated and IL-1beta-stimulated cells in the presence of p38 MAP kinase activator (anisomycin) and inhibitor (SB 203580) was evaluated. Phytic Acid 72-75 mitogen-activated protein kinase 14 Homo sapiens 54-57 23285690-6 2012 Furthermore, the role of signaling pathways involving p38 MAP kinase in IP6-induced down-regulation of IL-8 secretion by unstimulated and IL-1beta-stimulated cells in the presence of p38 MAP kinase activator (anisomycin) and inhibitor (SB 203580) was evaluated. Phytic Acid 72-75 mitogen-activated protein kinase 14 Homo sapiens 183-186 23285690-7 2012 IP6 inhibited activity of recombinant p38 MAPK activity in dose-dependent manner. Phytic Acid 0-3 mitogen-activated protein kinase 14 Homo sapiens 38-41 23285690-8 2012 Treatment of cells with IP6 for 3 h resulted in decreased p38 MAP kinase expression in both unstimulated and stimulated with IL-1beta cells. Phytic Acid 24-27 mitogen-activated protein kinase 14 Homo sapiens 58-61 23285690-9 2012 The similar level of p38alpha mRNA was found in untreated and treated with IP6 cells after 6 and 12 h. Incubation of Caco-2 cells with anisomycin resulted in upregulation of IL-8 secretion and their pretreatment with anisomycin prior to IP6 addition showed down-regulation of IL-8 secretion compared to cells treated with anisomycin alone. Phytic Acid 75-78 mitogen-activated protein kinase 14 Homo sapiens 21-29 23285690-9 2012 The similar level of p38alpha mRNA was found in untreated and treated with IP6 cells after 6 and 12 h. Incubation of Caco-2 cells with anisomycin resulted in upregulation of IL-8 secretion and their pretreatment with anisomycin prior to IP6 addition showed down-regulation of IL-8 secretion compared to cells treated with anisomycin alone. Phytic Acid 237-240 mitogen-activated protein kinase 14 Homo sapiens 21-29 23285690-10 2012 The findings of this study show that p38 MAPK could be one of the molecular targets for IP6 in the intestinal epithelial cells and that IP6 inhibitory effect on IL-8 secretion by Caco-2 cells could be mediated by its inhibition of p38 activity. Phytic Acid 88-91 mitogen-activated protein kinase 14 Homo sapiens 37-40 23285690-10 2012 The findings of this study show that p38 MAPK could be one of the molecular targets for IP6 in the intestinal epithelial cells and that IP6 inhibitory effect on IL-8 secretion by Caco-2 cells could be mediated by its inhibition of p38 activity. Phytic Acid 136-139 mitogen-activated protein kinase 14 Homo sapiens 231-234