PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23285690-5	2012	The aim of this study was to examine effect of IP6 on human p38alpha MAP kinase activity and the expression of gene encoding p38 MAP kinase in unstimulated and IL-1beta-stimulated Caco-2 cells.	Phytic Acid	47-50	mitogen-activated protein kinase 14	Homo sapiens	60-68	
23285690-5	2012	The aim of this study was to examine effect of IP6 on human p38alpha MAP kinase activity and the expression of gene encoding p38 MAP kinase in unstimulated and IL-1beta-stimulated Caco-2 cells.	Phytic Acid	47-50	mitogen-activated protein kinase 14	Homo sapiens	60-63	
23285690-6	2012	Furthermore, the role of signaling pathways involving p38 MAP kinase in IP6-induced down-regulation of IL-8 secretion by unstimulated and IL-1beta-stimulated cells in the presence of p38 MAP kinase activator (anisomycin) and inhibitor (SB 203580) was evaluated.	Phytic Acid	72-75	mitogen-activated protein kinase 14	Homo sapiens	54-57	
23285690-6	2012	Furthermore, the role of signaling pathways involving p38 MAP kinase in IP6-induced down-regulation of IL-8 secretion by unstimulated and IL-1beta-stimulated cells in the presence of p38 MAP kinase activator (anisomycin) and inhibitor (SB 203580) was evaluated.	Phytic Acid	72-75	mitogen-activated protein kinase 14	Homo sapiens	183-186	
23285690-7	2012	IP6 inhibited activity of recombinant p38 MAPK activity in dose-dependent manner.	Phytic Acid	0-3	mitogen-activated protein kinase 14	Homo sapiens	38-41	
23285690-8	2012	Treatment of cells with IP6 for 3 h resulted in decreased p38 MAP kinase expression in both unstimulated and stimulated with IL-1beta cells.	Phytic Acid	24-27	mitogen-activated protein kinase 14	Homo sapiens	58-61	
23285690-9	2012	The similar level of p38alpha mRNA was found in untreated and treated with IP6 cells after 6 and 12 h. Incubation of Caco-2 cells with anisomycin resulted in upregulation of IL-8 secretion and their pretreatment with anisomycin prior to IP6 addition showed down-regulation of IL-8 secretion compared to cells treated with anisomycin alone.	Phytic Acid	75-78	mitogen-activated protein kinase 14	Homo sapiens	21-29	
23285690-9	2012	The similar level of p38alpha mRNA was found in untreated and treated with IP6 cells after 6 and 12 h. Incubation of Caco-2 cells with anisomycin resulted in upregulation of IL-8 secretion and their pretreatment with anisomycin prior to IP6 addition showed down-regulation of IL-8 secretion compared to cells treated with anisomycin alone.	Phytic Acid	237-240	mitogen-activated protein kinase 14	Homo sapiens	21-29	
23285690-10	2012	The findings of this study show that p38 MAPK could be one of the molecular targets for IP6 in the intestinal epithelial cells and that IP6 inhibitory effect on IL-8 secretion by Caco-2 cells could be mediated by its inhibition of p38 activity.	Phytic Acid	88-91	mitogen-activated protein kinase 14	Homo sapiens	37-40	
23285690-10	2012	The findings of this study show that p38 MAPK could be one of the molecular targets for IP6 in the intestinal epithelial cells and that IP6 inhibitory effect on IL-8 secretion by Caco-2 cells could be mediated by its inhibition of p38 activity.	Phytic Acid	136-139	mitogen-activated protein kinase 14	Homo sapiens	231-234