PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29746542-0 2018 Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect. Phytic Acid 103-106 DEAD-box helicase 19B Homo sapiens 35-39 29782832-2 2018 Dbp5 ATPase activity is regulated by several factors, including RNA, the nucleoporin proteins Nup159 and Gle1, and the endogenous small-molecule inositol hexakisphosphate (InsP6). Phytic Acid 145-170 DEAD-box helicase 19B Homo sapiens 0-4 31344122-0 2019 Correction: Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect. Phytic Acid 115-118 DEAD-box helicase 19B Homo sapiens 47-51 31344122-0 2019 Correction: Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect. Phytic Acid 115-118 DEAD-box helicase 19B Homo sapiens 52-57 29746542-0 2018 Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect. Phytic Acid 103-106 DEAD-box helicase 19B Homo sapiens 40-45 29746542-1 2018 DBP5, also known as DDX19, GLE1 and inositol hexakisphosphate (IP6) function in messenger RNA (mRNA) export at the cytoplasmic surface of the nuclear pore complex in eukaryotic cells. Phytic Acid 36-61 DEAD-box helicase 19B Homo sapiens 0-4 29746542-1 2018 DBP5, also known as DDX19, GLE1 and inositol hexakisphosphate (IP6) function in messenger RNA (mRNA) export at the cytoplasmic surface of the nuclear pore complex in eukaryotic cells. Phytic Acid 63-66 DEAD-box helicase 19B Homo sapiens 0-4 29746542-1 2018 DBP5, also known as DDX19, GLE1 and inositol hexakisphosphate (IP6) function in messenger RNA (mRNA) export at the cytoplasmic surface of the nuclear pore complex in eukaryotic cells. Phytic Acid 63-66 DEAD-box helicase 19B Homo sapiens 20-25 29746542-2 2018 DBP5 is a DEAD-box RNA helicase, and its activity is stimulated by interactions with GLE1 and IP6. Phytic Acid 94-97 DEAD-box helicase 19B Homo sapiens 0-4 29746542-5 2018 The expression of some cytoplasmic mRNA subsets (e.g. cell cycle, DNA replication) was commonly suppressed by the knock-down of DBP5, GLE1 and IPPK (IP6 synthetic enzyme). Phytic Acid 149-152 DEAD-box helicase 19B Homo sapiens 128-132 28869701-0 2017 Nup42 and IP6 coordinate Gle1 stimulation of Dbp5/DDX19B for mRNA export in yeast and human cells. Phytic Acid 10-13 DEAD-box helicase 19B Homo sapiens 50-56 28869701-8 2017 In vitro, Nup42-CTD and IP6 stimulate Gle1/hGle1B activation of Dbp5 and DDX19B recombinant proteins in similar, nonadditive manners, demonstrating complete functional conservation between humans and S. cerevisiae. Phytic Acid 24-27 DEAD-box helicase 19B Homo sapiens 64-68 28869701-8 2017 In vitro, Nup42-CTD and IP6 stimulate Gle1/hGle1B activation of Dbp5 and DDX19B recombinant proteins in similar, nonadditive manners, demonstrating complete functional conservation between humans and S. cerevisiae. Phytic Acid 24-27 DEAD-box helicase 19B Homo sapiens 73-79 28869701-6 2017 A nup42-CTD/gle1-CTD/Dbp5 trimeric complex forms in the presence of IP6 . Phytic Acid 68-71 DEAD-box helicase 19B Homo sapiens 21-25 21949122-2 2011 During messenger (m)RNA export, Gle1 bound to inositol hexakisphosphate (IP(6)) acts via Dbp5 to facilitate remodeling of mRNA-protein complexes. Phytic Acid 46-71 DEAD-box helicase 19B Homo sapiens 89-93 23128325-3 2013 For the regulation of its RNA-dependent ATPase activity during late steps of nuclear transport, Dbp5 requires the nucleoporin Nup159 and its cofactors Gle1 and IP6. Phytic Acid 160-163 DEAD-box helicase 19B Homo sapiens 96-100 24275432-2 2014 During export, Gle1 in conjunction with inositol hexakisphosphate (IP6) spatially regulates the activity of the DEAD-box protein Dbp5 at the NPC cytoplasmic face. Phytic Acid 40-65 DEAD-box helicase 19B Homo sapiens 129-133 24275432-2 2014 During export, Gle1 in conjunction with inositol hexakisphosphate (IP6) spatially regulates the activity of the DEAD-box protein Dbp5 at the NPC cytoplasmic face. Phytic Acid 67-70 DEAD-box helicase 19B Homo sapiens 129-133 22064466-4 2011 An important step during this maturation process occurs at the cytoplasmic face of the nuclear pore complex (NPC) where the export protein Gle1 bound to inositol hexakisphosphate (IP 6) spatially activates the ATP-hydrolysis and mRNP-remodeling activity of the DEAD-box protein Dbp5. Phytic Acid 153-178 DEAD-box helicase 19B Homo sapiens 278-282 20023400-5 2010 Biochemical studies show that Gle1 and inositol hexaphosphate (IP6) activate Dbp5"s ATPase activity at the cytoplasmic face of NPC, therefore providing critical spatial regulation of mRNP remodeling during directional transport. Phytic Acid 39-61 DEAD-box helicase 19B Homo sapiens 77-81 21576266-2 2011 At cytoplasmic NPC filaments, the ATPase activity of DEAD-box protein Dbp5 is activated by inositol hexakisphosphate (IP(6))-bound Gle1 to mediate remodeling of mRNA-protein (mRNP) complexes. Phytic Acid 91-116 DEAD-box helicase 19B Homo sapiens 70-74 21081843-6 2010 Further, the Dbp5 interacting protein Gle1 and its co-factor inositol hexakisphosphate (IP 6) have been shown to participate in the termination process. Phytic Acid 61-86 DEAD-box helicase 19B Homo sapiens 13-17 21081843-6 2010 Further, the Dbp5 interacting protein Gle1 and its co-factor inositol hexakisphosphate (IP 6) have been shown to participate in the termination process. Phytic Acid 88-92 DEAD-box helicase 19B Homo sapiens 13-17 20023400-5 2010 Biochemical studies show that Gle1 and inositol hexaphosphate (IP6) activate Dbp5"s ATPase activity at the cytoplasmic face of NPC, therefore providing critical spatial regulation of mRNP remodeling during directional transport. Phytic Acid 63-66 DEAD-box helicase 19B Homo sapiens 77-81 16783364-5 2006 Interestingly, Gle1 binds directly to inositol hexakisphosphate (InsP6) and InsP6 potentiates the Gle1-mediated stimulation of Dbp5. Phytic Acid 38-63 DEAD-box helicase 19B Homo sapiens 127-131