PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29111280-7 2019 Inositol pyrophosphates, synthesized by inositol hexakisphosphate (IP6) kinase 1 (IP6K1) and competitive with 3,4,5-bisphosphate (PIP3) to bind the PH domain of Akt/PKB, demonstrate the ability to inhibit Akt signaling. Phytic Acid 40-65 thymoma viral proto-oncogene 1 Mus musculus 161-168 29111280-7 2019 Inositol pyrophosphates, synthesized by inositol hexakisphosphate (IP6) kinase 1 (IP6K1) and competitive with 3,4,5-bisphosphate (PIP3) to bind the PH domain of Akt/PKB, demonstrate the ability to inhibit Akt signaling. Phytic Acid 40-65 thymoma viral proto-oncogene 1 Mus musculus 161-164 28962394-8 2015 IP6 administration also inhibited the activation of Akt and cyclin D1. Phytic Acid 0-3 thymoma viral proto-oncogene 1 Mus musculus 52-55 34969251-8 2022 Mechanism studies showed that PA exerted an anti-MIR effect by inhibiting the AKT/NF-kappaB signaling pathway. Phytic Acid 30-32 thymoma viral proto-oncogene 1 Mus musculus 78-81 30806292-9 2019 IP6-fed F1 mice showed reduced tumorigenesis along with reduced expression of the PI3K/Akt pathway miR-21 and downstream targets. Phytic Acid 0-3 thymoma viral proto-oncogene 1 Mus musculus 87-90 30806292-10 2019 The PI3K/Akt pathway and miR-21 are involved in transplacental lung tumorigenesis, whereas IP6 seemed to affect lung tumorigenesis by suppressing the expression of the PI3K/Akt pathway in F1 mice. Phytic Acid 91-94 thymoma viral proto-oncogene 1 Mus musculus 173-176 24847908-2 2014 IP6K inhibition may increase Akt activation in mesenchymal stem cells (MSCs), resulting in enhanced cardiac protective effect after transplantation. Phytic Acid 0-3 thymoma viral proto-oncogene 1 Mus musculus 29-32