PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26647627-7 2015 Stimulation of Caco-2 with pro-inflammatory factors (LPS and IL-1beta) resulted in an up-expression of iNOS mRNA at 6 and 12 h. Cells exposed to IP6 only revealed significant reduction in iNOS gene transcription after 12 h. A decrease in iNOS transcription by IP6 following the gene induction by proinflammatory agents in 6 and 12 h lasting cultures was also determined. Phytic Acid 260-263 interleukin 1 beta Homo sapiens 61-69 25745771-0 2014 Influence of inositol hexaphosphate on the expression of selected proliferation markers in IL-1beta-stimulated intestinal epithelial cells. Phytic Acid 13-35 interleukin 1 beta Homo sapiens 91-99 26647627-5 2015 In this study, the effect of inositol hexaphosphate (IP6), dietary phytochemical, on the mRNA expression of iNOS stimulated with bacterial lipopolysaccharides (Escherichia coli and Salmonella typhimurium) and IL-1beta in intestinal cells Caco-2 for 6 and 12 h was investigated. Phytic Acid 29-51 interleukin 1 beta Homo sapiens 209-217 26647627-5 2015 In this study, the effect of inositol hexaphosphate (IP6), dietary phytochemical, on the mRNA expression of iNOS stimulated with bacterial lipopolysaccharides (Escherichia coli and Salmonella typhimurium) and IL-1beta in intestinal cells Caco-2 for 6 and 12 h was investigated. Phytic Acid 53-56 interleukin 1 beta Homo sapiens 209-217 26647627-7 2015 Stimulation of Caco-2 with pro-inflammatory factors (LPS and IL-1beta) resulted in an up-expression of iNOS mRNA at 6 and 12 h. Cells exposed to IP6 only revealed significant reduction in iNOS gene transcription after 12 h. A decrease in iNOS transcription by IP6 following the gene induction by proinflammatory agents in 6 and 12 h lasting cultures was also determined. Phytic Acid 145-148 interleukin 1 beta Homo sapiens 61-69 25745771-6 2014 The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. Phytic Acid 152-155 interleukin 1 beta Homo sapiens 25-33 25745771-6 2014 The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. Phytic Acid 152-155 interleukin 1 beta Homo sapiens 74-82 25745771-6 2014 The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. Phytic Acid 152-155 interleukin 1 beta Homo sapiens 181-188 25745771-6 2014 The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. Phytic Acid 152-155 interleukin 1 beta Homo sapiens 74-82 25745771-6 2014 The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. Phytic Acid 152-155 interleukin 1 beta Homo sapiens 329-336 25745771-6 2014 The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. Phytic Acid 152-155 interleukin 1 beta Homo sapiens 25-33 25745771-6 2014 The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. Phytic Acid 152-155 interleukin 1 beta Homo sapiens 74-82 25745771-6 2014 The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. Phytic Acid 152-155 interleukin 1 beta Homo sapiens 181-188 25745771-6 2014 The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. Phytic Acid 152-155 interleukin 1 beta Homo sapiens 74-82 25745771-6 2014 The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. Phytic Acid 152-155 interleukin 1 beta Homo sapiens 329-336 25745771-1 2014 The aim of the present study was to examine the influence of IP6, a naturally occurring phytochem- ical, on the expression of genes coding for proliferation markers, i.e., cyclin D1 (CCND1) and histone H3 in IL-1beta-stimulated intestinal cancer cell line Caco-2. Phytic Acid 61-64 interleukin 1 beta Homo sapiens 208-216 25745771-2 2014 Quantification of genes expression was carried out using real time RT-QPCR technique in Caco-2 cells after treatment with IL-1beta, 1 and 2.5 mM of IP6 for 3, 6 and 12 h. In separate cultures, cells were incubated with IL-1beta for the indicated times. Phytic Acid 148-151 interleukin 1 beta Homo sapiens 122-139 25745771-5 2014 IP6 had no influence on IL-1beta-stimulated CCND1 expression for 3 and 6 h. After 12 h, statistically significant decrease in CCND1 mRNA was observed in cells exposed to IL-1beta and IP6 (1 and 2.5 mM) in relation to cells treated with IL-1beta only. Phytic Acid 0-3 interleukin 1 beta Homo sapiens 170-178 25745771-5 2014 IP6 had no influence on IL-1beta-stimulated CCND1 expression for 3 and 6 h. After 12 h, statistically significant decrease in CCND1 mRNA was observed in cells exposed to IL-1beta and IP6 (1 and 2.5 mM) in relation to cells treated with IL-1beta only. Phytic Acid 0-3 interleukin 1 beta Homo sapiens 170-178 23285690-6 2012 Furthermore, the role of signaling pathways involving p38 MAP kinase in IP6-induced down-regulation of IL-8 secretion by unstimulated and IL-1beta-stimulated cells in the presence of p38 MAP kinase activator (anisomycin) and inhibitor (SB 203580) was evaluated. Phytic Acid 72-75 interleukin 1 beta Homo sapiens 138-146 23610962-5 2013 IP6 had suppressive effect on basal and IL-1beta-stimulated IL-8 secretion by cells. Phytic Acid 0-3 interleukin 1 beta Homo sapiens 40-48 23610962-8 2013 In addition, total PTK activity in both unstimulated and IL-1beta stimulated cells was determined in the presence of IP6. Phytic Acid 117-120 interleukin 1 beta Homo sapiens 57-65 23285696-0 2012 The effect of phytic acid on the expression of NF-kappaB, IL-6 and IL-8 in IL-1beta-stimulated human colonic epithelial cells. Phytic Acid 14-25 interleukin 1 beta Homo sapiens 75-83 23285690-8 2012 Treatment of cells with IP6 for 3 h resulted in decreased p38 MAP kinase expression in both unstimulated and stimulated with IL-1beta cells. Phytic Acid 24-27 interleukin 1 beta Homo sapiens 125-133 17160716-0 2007 Phytic acid modulates in vitro IL-8 and IL-6 release from colonic epithelial cells stimulated with LPS and IL-1beta. Phytic Acid 0-11 interleukin 1 beta Homo sapiens 107-115 22415590-0 2012 The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1beta-stimulated colon cancer cells. Phytic Acid 14-36 interleukin 1 beta Homo sapiens 117-125 22415590-5 2012 In the present study, the effect of IP6 on the expression of MMP and TIMP genes was evaluated in unstimulated and IL-1beta-stimulated colon cancer cell line Caco-2. Phytic Acid 36-39 interleukin 1 beta Homo sapiens 114-122 22415590-6 2012 MATERIALS AND METHODS: Real-time QRT-PCR was used to validate the transcription level of selected MMP and TIMP genes in Caco-2 cells after treatment with 1 ng/ml of IL-1beta, 2.5 mM of IP6, and both for 6, 12, and 24 h. RESULTS: Stimulation of cells with IL-1beta only resulted in an overexpression of MMP and their TIMP mRNAs. Phytic Acid 185-188 interleukin 1 beta Homo sapiens 165-173 22415590-8 2012 IP6 was also an efficient downregulator of MMP-1, MMP-9, and TIMP-2 genes transcription stimulated by IL-1beta in 6 h lasting culture. Phytic Acid 0-3 interleukin 1 beta Homo sapiens 102-110 22415590-9 2012 After 12 h, IL-1beta-induced MMP-2 mRNA expression was significantly reduced by IP6. Phytic Acid 80-83 interleukin 1 beta Homo sapiens 12-20 22415590-11 2012 IP6 (2.5 mM) influences constitutive expression of both MMP and TIMP genes and downregulates IL-1beta stimulated transcription of some of these genes. Phytic Acid 0-3 interleukin 1 beta Homo sapiens 93-101 17160716-2 2007 The aim of this study was to examine the role of PA in immunologic function of intestinal epithelial cells by analyzing its effect on interleukin (IL)-8 and IL-6 secretion by colonocytes and its role in the response of these cells to bacterial lipopolysaccharides (LPS) and IL-1beta. Phytic Acid 49-51 interleukin 1 beta Homo sapiens 274-282 17160716-5 2007 PA had a suppressive effect on IL-8 basal release and it dose dependently reduced IL-8 secretion by colonocytes stimulated with LPS and IL-1beta. Phytic Acid 0-2 interleukin 1 beta Homo sapiens 136-144 17160716-7 2007 PA was also an efficient down-regulator of IL-6 secretion stimulated by binary actions of LPS and IL-1beta. Phytic Acid 0-2 interleukin 1 beta Homo sapiens 98-106 28797636-3 2017 The aim of the study was to examine the influence of inositol hexaphosphate (IP6), a naturally occurring phytochemical, on the expression of genes encoding COX and LOX isoforms and synthesis of their products (PGE2 and LTB4) in colon cancer cell line Caco-2 stimulated with pro-inflammatory agents (IL-1beta/TNFalpha). Phytic Acid 53-75 interleukin 1 beta Homo sapiens 299-307 28797636-3 2017 The aim of the study was to examine the influence of inositol hexaphosphate (IP6), a naturally occurring phytochemical, on the expression of genes encoding COX and LOX isoforms and synthesis of their products (PGE2 and LTB4) in colon cancer cell line Caco-2 stimulated with pro-inflammatory agents (IL-1beta/TNFalpha). Phytic Acid 77-80 interleukin 1 beta Homo sapiens 299-307