PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29746542-0 2018 Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect. Phytic Acid 103-106 inositol-pentakisphosphate 2-kinase Homo sapiens 55-59 33476323-6 2021 Knockout (KO) of IPPK from CEM and MT-4 cells depleted cellular IP6 in both T cell lines, and IPMK disruption reduced the levels of both IP5 and IP6. Phytic Acid 64-67 inositol-pentakisphosphate 2-kinase Homo sapiens 17-21 33422459-7 2021 Surprisingly, the loss of IPPK, an enzyme thought to catalyse the rate limiting step of IP6 (phytic acid) synthesis, was also recorded. Phytic Acid 88-91 inositol-pentakisphosphate 2-kinase Homo sapiens 26-30 33422459-7 2021 Surprisingly, the loss of IPPK, an enzyme thought to catalyse the rate limiting step of IP6 (phytic acid) synthesis, was also recorded. Phytic Acid 93-104 inositol-pentakisphosphate 2-kinase Homo sapiens 26-30 32776974-2 2020 However, knockout cells lacking inositol-pentakisphosphate 2-kinase (IPPK-KO), the enzyme that produces IP6 by phosphorylation of inositol pentakisphosphate (IP5), were still able to produce infectious HIV-1 particles at a greatly reduced rate. Phytic Acid 104-107 inositol-pentakisphosphate 2-kinase Homo sapiens 32-67 32776974-2 2020 However, knockout cells lacking inositol-pentakisphosphate 2-kinase (IPPK-KO), the enzyme that produces IP6 by phosphorylation of inositol pentakisphosphate (IP5), were still able to produce infectious HIV-1 particles at a greatly reduced rate. Phytic Acid 104-107 inositol-pentakisphosphate 2-kinase Homo sapiens 69-73 32493769-0 2020 Suramin and NF449 are IP5K inhibitors that disrupt IP6-mediated regulation of cullin RING ligase and sensitize cancer cells to MLN4924/pevonedistat. Phytic Acid 51-54 inositol-pentakisphosphate 2-kinase Homo sapiens 22-26 32493769-1 2020 Inositol hexakisphosphate (IP6) is an abundant metabolite synthesized from inositol 1,3,4,5,6-pentakisphosphate [Ins(1,3,4,5,6)P5, or IP5] by the single Ins(1,3,4,5,6)P5 2-kinase (IP5K/IPPK). Phytic Acid 0-25 inositol-pentakisphosphate 2-kinase Homo sapiens 180-184 32493769-1 2020 Inositol hexakisphosphate (IP6) is an abundant metabolite synthesized from inositol 1,3,4,5,6-pentakisphosphate [Ins(1,3,4,5,6)P5, or IP5] by the single Ins(1,3,4,5,6)P5 2-kinase (IP5K/IPPK). Phytic Acid 0-25 inositol-pentakisphosphate 2-kinase Homo sapiens 185-189 32493769-1 2020 Inositol hexakisphosphate (IP6) is an abundant metabolite synthesized from inositol 1,3,4,5,6-pentakisphosphate [Ins(1,3,4,5,6)P5, or IP5] by the single Ins(1,3,4,5,6)P5 2-kinase (IP5K/IPPK). Phytic Acid 27-30 inositol-pentakisphosphate 2-kinase Homo sapiens 180-184 32493769-1 2020 Inositol hexakisphosphate (IP6) is an abundant metabolite synthesized from inositol 1,3,4,5,6-pentakisphosphate [Ins(1,3,4,5,6)P5, or IP5] by the single Ins(1,3,4,5,6)P5 2-kinase (IP5K/IPPK). Phytic Acid 27-30 inositol-pentakisphosphate 2-kinase Homo sapiens 185-189 32493769-7 2020 Both suramin and NF449 disrupted IP6-dependent sequestration of CRL by the deneddylase COP9 Signalosome (CSN), thereby affecting CRL activity cycle and component dynamics in an IP5K-dependent manner. Phytic Acid 33-36 inositol-pentakisphosphate 2-kinase Homo sapiens 177-181 31394817-5 2019 Recently, the inositol polyphosphate metabolites (IP6, IP7) and their metabolic enzymes (IP5K, IP6K) have been discovered to participate in CRL-CSN complex formation as well as stimulus-dependent dissociation. Phytic Acid 14-36 inositol-pentakisphosphate 2-kinase Homo sapiens 89-93 31394817-5 2019 Recently, the inositol polyphosphate metabolites (IP6, IP7) and their metabolic enzymes (IP5K, IP6K) have been discovered to participate in CRL-CSN complex formation as well as stimulus-dependent dissociation. Phytic Acid 50-53 inositol-pentakisphosphate 2-kinase Homo sapiens 89-93 31344122-0 2019 Correction: Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect. Phytic Acid 115-118 inositol-pentakisphosphate 2-kinase Homo sapiens 67-71 31031142-4 2019 We show that IP6 and inositol pentakisphosphate 2-kinase (IPPK) are required for necroptosis as IPPK deletion ablated IP6 production and inhibited necroptosis. Phytic Acid 13-16 inositol-pentakisphosphate 2-kinase Homo sapiens 96-100 31031142-4 2019 We show that IP6 and inositol pentakisphosphate 2-kinase (IPPK) are required for necroptosis as IPPK deletion ablated IP6 production and inhibited necroptosis. Phytic Acid 118-121 inositol-pentakisphosphate 2-kinase Homo sapiens 21-56 31031142-4 2019 We show that IP6 and inositol pentakisphosphate 2-kinase (IPPK) are required for necroptosis as IPPK deletion ablated IP6 production and inhibited necroptosis. Phytic Acid 118-121 inositol-pentakisphosphate 2-kinase Homo sapiens 58-62 31031142-4 2019 We show that IP6 and inositol pentakisphosphate 2-kinase (IPPK) are required for necroptosis as IPPK deletion ablated IP6 production and inhibited necroptosis. Phytic Acid 118-121 inositol-pentakisphosphate 2-kinase Homo sapiens 96-100 32776974-7 2020 Several attempts to make IP6/IP5 deficient stable cells were not successful, but transient expression of the enzyme multiple inositol polyphosphate phosphatase-1 (MINPP1) into IPPK-KOs resulted in near ablation of IP6 and IP5. Phytic Acid 214-217 inositol-pentakisphosphate 2-kinase Homo sapiens 176-180 29746542-5 2018 The expression of some cytoplasmic mRNA subsets (e.g. cell cycle, DNA replication) was commonly suppressed by the knock-down of DBP5, GLE1 and IPPK (IP6 synthetic enzyme). Phytic Acid 149-152 inositol-pentakisphosphate 2-kinase Homo sapiens 143-147 24165122-1 2013 Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) converts inositol 1,3,4,5,6-pentakisphosphate(IP5) to inositol hexakisphosphate (IP6). Phytic Acid 107-132 inositol-pentakisphosphate 2-kinase Homo sapiens 47-51 26976604-0 2016 Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function. Phytic Acid 0-25 inositol-pentakisphosphate 2-kinase Homo sapiens 45-49 26976604-0 2016 Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function. Phytic Acid 27-30 inositol-pentakisphosphate 2-kinase Homo sapiens 45-49 28429156-1 2017 Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IP5 2-K) is an enzyme that catalyses the formation of phytic acid (IP6) from IP5 and ATP. Phytic Acid 101-112 inositol-pentakisphosphate 2-kinase Homo sapiens 0-45 28429156-1 2017 Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IP5 2-K) is an enzyme that catalyses the formation of phytic acid (IP6) from IP5 and ATP. Phytic Acid 114-117 inositol-pentakisphosphate 2-kinase Homo sapiens 0-45 24165122-1 2013 Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) converts inositol 1,3,4,5,6-pentakisphosphate(IP5) to inositol hexakisphosphate (IP6). Phytic Acid 134-137 inositol-pentakisphosphate 2-kinase Homo sapiens 47-51 35499048-2 2022 Inositol pentakisphosphate 2- kinase 1 (IPK1) gene has been reported to be an important gene for PA biosynthesis. Phytic Acid 97-99 inositol-pentakisphosphate 2-kinase Homo sapiens 0-38 22745128-1 2012 Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IP(5) 2-K) catalyzes the synthesis of inositol 1,2,3,4,5,6-hexakisphosphate from ATP and IP(5). Phytic Acid 85-122 inositol-pentakisphosphate 2-kinase Homo sapiens 0-45 35499048-2 2022 Inositol pentakisphosphate 2- kinase 1 (IPK1) gene has been reported to be an important gene for PA biosynthesis. Phytic Acid 97-99 inositol-pentakisphosphate 2-kinase Homo sapiens 40-44 23884422-2 2013 IPK1 (inositol 1,3,4,5,6-pentakisphosphate 2-kinase) phosphorylates inositol 1,3,4,5,6-pentakisphosphate to inositol 1,2,3,4,5,6-hexakisphosphate; however, the mechanism of IP recognition employed by IPK1 is currently unresolved. Phytic Acid 108-145 inositol-pentakisphosphate 2-kinase Homo sapiens 0-4 23884422-2 2013 IPK1 (inositol 1,3,4,5,6-pentakisphosphate 2-kinase) phosphorylates inositol 1,3,4,5,6-pentakisphosphate to inositol 1,2,3,4,5,6-hexakisphosphate; however, the mechanism of IP recognition employed by IPK1 is currently unresolved. Phytic Acid 108-145 inositol-pentakisphosphate 2-kinase Homo sapiens 200-204